S1PR1 and HTR1A

Number of citations of the paper that reports this interaction (PubMedID 11854302)
0

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		S1PR1	HTR1A
Description		sphingosine-1-phosphate receptor 1	5-hydroxytryptamine receptor 1A
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Membrane Raft Presynapse	Plasma Membrane Membrane Dendrite Cell Projection Synapse
	Molecular Function	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Protein Binding Sphingosine-1-phosphate Receptor Activity Sphingolipid Binding	Gi/o-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Receptor-receptor Interaction Serotonin Receptor Activity
	Biological Process	Angiogenesis Blood Vessel Maturation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Sphingosine-1-phosphate Receptor Signaling Pathway Chemotaxis Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Brain Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Cell Migration Transmission Of Nerve Impulse Lamellipodium Assembly Actin Cytoskeleton Organization Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Leukocyte Chemotaxis Regulation Of Bone Resorption Endothelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Positive Chemotaxis Negative Regulation Of Stress Fiber Assembly Heart Trabecula Morphogenesis T Cell Migration	Behavioral Fear Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Regulation Of Serotonin Secretion Regulation Of Vasoconstriction Exploration Behavior Regulation Of Dopamine Metabolic Process Serotonin Metabolic Process Regulation Of Hormone Secretion Regulation Of Behavior
Pathways		Lysosphingolipid and LPA receptors Interleukin-4 and Interleukin-13 signaling Potential therapeutics for SARS	Serotonin receptors
Drugs		Fingolimod Ponesimod Siponimod Ozanimod	Eletriptan Ziprasidone Methysergide Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Loxapine Pramipexole Methylphenidate Imipramine Chlorpromazine Buspirone Haloperidol Nortriptyline Amoxapine Propranolol Fenfluramine Lisuride Trazodone Sumatriptan Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Alprenolol Ondansetron Oxymetazoline Naratriptan Pindolol Dopamine Ergoloid mesylate Doxepin Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Paliperidone Penbutolol Yohimbine Acepromazine Alverine Molindone Pipotiazine Lysergic acid diethylamide Dapoxetine Bifeprunox Flibanserin Iloperidone Lofexidine Lesopitron Rotigotine MN-305 LI-301 Naluzotan Cariprazine Mianserin Pizotifen Asenapine Xaliproden Dotarizine Sarizotan Repinotan Robalzotan Vilazodone Bopindolol Cinitapride Lurasidone Perospirone Cannabidiol Vortioxetine Brexpiprazole Dosulepin Pirlindole Tianeptine Setiptiline Dihydroergocornine Tetrahydrocannabivarin Pardoprunox Gilteritinib Lecozotan Lecozotan Tiapride Dihydroergocristine Medical Cannabis 5-methoxy-N,N-dimethyltryptamine Nabiximols Aripiprazole lauroxil SEP-363856 Serdexmethylphenidate
Diseases
GWAS		Irritable bowel syndrome ( 29673008) Lymphocyte count ( 27863252 29403010 32888494) Lymphocyte percentage of white cells ( 32888494) Multiple sclerosis and C-reactive protein levels (pleiotropy) ( 26920376) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Sensorimotor dexterity ( 31596458) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)	Adult body size ( 32376654) Alcohol and nicotine co-dependence ( 23216389) Body mass index ( 20935630) Bronchopulmonary dysplasia ( 23897914) Daytime nap ( 33568662) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		9 interacting genes: AKT1 APP CAV1 CMSS1 GNAI1 GNAI3 HTR1A HTR1D PDGFRB	8 interacting genes: FGFR1 GABBR2 GNAI3 GPR26 HTR1B HTR1D S1PR1 S1PR3
Entrez ID		1901	3350
HPRD ID		03578	00190
Ensembl ID		ENSG00000170989	ENSG00000178394
Uniprot IDs		P21453	A8K5W4 P08908 Q5ZGX3
PDB IDs		3V2W 3V2Y 7EO2 7EO4 7EVY 7EVZ 7EW0 7EW7 7TD3 7TD4 7VIE 7VIF 7VIG 7VIH 7WF7 8G94 8YIC	7E2X 7E2Y 7E2Z 8FY8 8FYE 8FYL 8FYT 8FYX 8JSP 8JT6 8PJK 8PKM 8W8B
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Gi/o-coupled Serotonin Receptor Activity Regulation Of Nitric Oxide Metabolic Process G Protein-coupled Receptor Binding Cellular Response To Growth Factor Stimulus Peptidase Activator Activity Regulation Of Response To Endoplasmic Reticulum Stress Response To Growth Factor Regulation Of Small Molecule Metabolic Process Serotonin Receptor Activity Regulation Of Metal Ion Transport G Protein-coupled Serotonin Receptor Activity Enzyme Binding Guanyl Nucleotide Binding Neurotransmitter Receptor Activity Regulation Of Transport Positive Regulation Of Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size G-protein Beta/gamma-subunit Complex Binding Positive Regulation Of Small Molecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Prostaglandin E Cell Cortex Reactive Nitrogen Species Metabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Cholesterol Metabolic Process Regulation Of Locomotion Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Cholesterol Biosynthetic Process Nitric Oxide Metabolic Process Signal Transduction Positive Regulation Of Monoatomic Ion Transport Regulation Of System Process Vasoconstriction Positive Regulation Of Proteolysis Plasma Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Cell Motility Response To Ketone	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Gi/o-coupled Serotonin Receptor Activity Sphingosine-1-phosphate Receptor Activity Negative Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Signal Transduction G Protein-coupled Serotonin Receptor Activity Serotonin Receptor Activity Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Plasma Membrane Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Cell-cell Signaling Vasoconstriction Signaling Cell Communication G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Cardiac Muscle Tissue Growth Positive Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Parathyroid Hormone Secretion Trans-synaptic Signaling Synaptic Signaling G Protein-coupled Receptor Binding Regulation Of Behavior Membrane Positive Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Establishment Of Endothelial Barrier Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Regulation Of Lateral Mesodermal Cell Fate Specification Serotonergic Synapse Negative Regulation Of Serotonin Secretion G Protein-coupled GABA Receptor Complex G Protein-coupled GABA Receptor Activity G Protein-coupled Receptor Heterodimeric Complex Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Ventricular Zone Neuroblast Division Regulation Of Mitotic Cell Cycle DNA Replication Orbitofrontal Cortex Development GABA Receptor Complex Sphingolipid Binding Growth Involved In Heart Morphogenesis Positive Regulation Of Chemotaxis
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