S1PR1 and HTR1D

Number of citations of the paper that reports this interaction (PubMedID 11854302)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		S1PR1	HTR1D
Description		sphingosine-1-phosphate receptor 1	5-hydroxytryptamine receptor 1D
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Membrane Raft Presynapse	Plasma Membrane Membrane Dendrite Synapse
	Molecular Function	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Protein Binding Sphingosine-1-phosphate Receptor Activity Sphingolipid Binding	Gi/o-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Neurotransmitter Receptor Activity Serotonin Receptor Activity
	Biological Process	Angiogenesis Blood Vessel Maturation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Sphingosine-1-phosphate Receptor Signaling Pathway Chemotaxis Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Brain Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Cell Migration Transmission Of Nerve Impulse Lamellipodium Assembly Actin Cytoskeleton Organization Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Leukocyte Chemotaxis Regulation Of Bone Resorption Endothelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Positive Chemotaxis Negative Regulation Of Stress Fiber Assembly Heart Trabecula Morphogenesis T Cell Migration	Smooth Muscle Contraction Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Intestine Smooth Muscle Contraction Regulation Of Locomotion Vasoconstriction Regulation Of Behavior
Pathways		Lysosphingolipid and LPA receptors Interleukin-4 and Interleukin-13 signaling Potential therapeutics for SARS	Serotonin receptors G alpha (i) signalling events
Drugs		Fingolimod Ponesimod Siponimod Ozanimod	Eletriptan Ziprasidone Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Loxapine Fenfluramine Lisuride Sumatriptan Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Almotriptan Oxymetazoline Naratriptan Rizatriptan Frovatriptan Ergoloid mesylate Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Paliperidone Yohimbine Lofexidine NXN-188 Setiptiline Dihydroergocornine Gilteritinib Lecozotan Tiapride Dihydroergocristine Aripiprazole lauroxil
Diseases
GWAS		Irritable bowel syndrome ( 29673008) Lymphocyte count ( 27863252 29403010 32888494) Lymphocyte percentage of white cells ( 32888494) Multiple sclerosis and C-reactive protein levels (pleiotropy) ( 26920376) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Sensorimotor dexterity ( 31596458) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Estimated glomerular filtration rate ( 31015462) Height ( 20881960 28552196) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		9 interacting genes: AKT1 APP CAV1 CMSS1 GNAI1 GNAI3 HTR1A HTR1D PDGFRB	3 interacting genes: HTR1A HTR1B S1PR1
Entrez ID		1901	3352
HPRD ID		03578	01636
Ensembl ID		ENSG00000170989	ENSG00000179546
Uniprot IDs		P21453	P28221
PDB IDs		3V2W 3V2Y 7EO2 7EO4 7EVY 7EVZ 7EW0 7EW7 7TD3 7TD4 7VIE 7VIF 7VIG 7VIH 7WF7 8G94 8YIC	7E32
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Gi/o-coupled Serotonin Receptor Activity Regulation Of Nitric Oxide Metabolic Process G Protein-coupled Receptor Binding Cellular Response To Growth Factor Stimulus Peptidase Activator Activity Regulation Of Response To Endoplasmic Reticulum Stress Response To Growth Factor Regulation Of Small Molecule Metabolic Process Serotonin Receptor Activity Regulation Of Metal Ion Transport G Protein-coupled Serotonin Receptor Activity Enzyme Binding Guanyl Nucleotide Binding Neurotransmitter Receptor Activity Regulation Of Transport Positive Regulation Of Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size G-protein Beta/gamma-subunit Complex Binding Positive Regulation Of Small Molecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Prostaglandin E Cell Cortex Reactive Nitrogen Species Metabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Cholesterol Metabolic Process Regulation Of Locomotion Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Cholesterol Biosynthetic Process Nitric Oxide Metabolic Process Signal Transduction Positive Regulation Of Monoatomic Ion Transport Regulation Of System Process Vasoconstriction Positive Regulation Of Proteolysis Plasma Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Cell Motility Response To Ketone	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Serotonin Secretion Gi/o-coupled Serotonin Receptor Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Binding Serotonin Receptor Activity G Protein-coupled Serotonin Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Behavior Positive Regulation Of Smooth Muscle Cell Proliferation G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Cardiac Muscle Tissue Growth Regulation Of Smooth Muscle Cell Proliferation Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Blood Vessel Diameter Maintenance Regulation Of Tube Size Serotonergic Synapse Negative Regulation Of Serotonin Secretion Sphingolipid Binding Growth Involved In Heart Morphogenesis System Process Vascular Process In Circulatory System Receptor-receptor Interaction G Protein-coupled Serotonin Receptor Complex Regulation Of Cell Population Proliferation Chemical Synaptic Transmission Circulatory System Process Trans-synaptic Signaling Blood Vessel Maturation Synaptic Signaling Phospholipase C-activating Serotonin Receptor Signaling Pathway Sphingosine-1-phosphate Receptor Activity Regulation Of Monoatomic Ion Transport Serotonin Receptor Signaling Pathway Serotonin Metabolic Process Dendrite Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Mediated Signaling Pathway Bone Remodeling Regulation Of Secretion By Cell Heart Trabecula Morphogenesis Regulation Of Dopamine Metabolic Process Cell-cell Signaling
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