S1PR1 and CAV1

Number of citations of the paper that reports this interaction (PubMedID 10921915)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		S1PR1	CAV1
Description		sphingosine-1-phosphate receptor 1	caveolin 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Membrane Raft Presynapse	Golgi Membrane Acrosomal Membrane Caveolar Macromolecular Signaling Complex Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Lipid Droplet Plasma Membrane Caveola Focal Adhesion Cilium Cell Cortex Membrane Basolateral Plasma Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm
	Molecular Function	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Protein Binding Sphingosine-1-phosphate Receptor Activity Sphingolipid Binding	Signaling Receptor Binding Patched Binding Protein Binding Oxysterol Binding Cholesterol Binding Peptidase Activator Activity Enzyme Binding Protein Kinase Binding Protein Tyrosine Kinase Inhibitor Activity Protein-macromolecule Adaptor Activity Small GTPase Binding Nitric-oxide Synthase Inhibitor Activity Identical Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Protein Heterodimerization Activity Nitric-oxide Synthase Binding ATPase Binding Molecular Adaptor Activity Inward Rectifier Potassium Channel Inhibitor Activity Protein Sequestering Activity
	Biological Process	Angiogenesis Blood Vessel Maturation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Sphingosine-1-phosphate Receptor Signaling Pathway Chemotaxis Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Brain Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Cell Migration Transmission Of Nerve Impulse Lamellipodium Assembly Actin Cytoskeleton Organization Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Leukocyte Chemotaxis Regulation Of Bone Resorption Endothelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Positive Chemotaxis Negative Regulation Of Stress Fiber Assembly Heart Trabecula Morphogenesis T Cell Migration	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Angiogenesis Vasculogenesis Response To Hypoxia Endothelial Cell Proliferation Negative Regulation Of Endothelial Cell Proliferation Negative Regulation Of Cytokine-mediated Signaling Pathway Regulation Of The Force Of Heart Contraction Glandular Epithelial Cell Differentiation Response To Ischemia Regulation Of The Force Of Heart Contraction By Chemical Signal Triglyceride Metabolic Process Nitric Oxide Biosynthetic Process Calcium Ion Transport Intracellular Calcium Ion Homeostasis Regulation Of Smooth Muscle Contraction Skeletal Muscle Tissue Development Lactation Intracellular Protein Localization Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Response To Bacterium Negative Regulation Of Signal Transduction Positive Regulation Of Calcium Ion Transport Into Cytosol Post-transcriptional Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Cholesterol Efflux Protein Transport Vesicle Organization Receptor-mediated Endocytosis Of Virus By Host Cell Regulation Of Fatty Acid Metabolic Process Cytokine-mediated Signaling Pathway Lipid Storage Cell Differentiation Regulation Of Blood Coagulation Cholesterol Transport Positive Regulation Of Cell Migration Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Epithelial Cell Differentiation Mammary Gland Development T Cell Costimulation Negative Regulation Of Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Receptor Internalization Maintenance Of Protein Location In Cell Response To Progesterone Intracellular Nitric Oxide Homeostasis Toll-like Receptor 4 Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Insulin Receptor Internalization Angiotensin-activated Signaling Pathway Vasoconstriction Cholesterol Homeostasis Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Response To Estrogen Protein Localization To Plasma Membrane Raft Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Vasoconstriction Nitric Oxide Metabolic Process Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Muscle Cell Cellular Homeostasis Fibroblast Proliferation Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Pinocytosis Regulation Of Cytosolic Calcium Ion Concentration Response To Calcium Ion Establishment Of Localization In Cell Membrane Depolarization Calcium Ion Homeostasis Mammary Gland Involution Canonical Wnt Signaling Pathway Negative Regulation Of Necroptotic Process Caveola Assembly Cellular Response To Misfolded Protein Cellular Response To Peptide Hormone Stimulus Cellular Response To Hyperoxia Cellular Response To Transforming Growth Factor Beta Stimulus Basement Membrane Organization Caveolin-mediated Endocytosis Regulation Of Heart Rate By Cardiac Conduction Negative Regulation Of Canonical Wnt Signaling Pathway Apoptotic Signaling Pathway Regulation Of Membrane Repolarization During Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Cold-induced Thermogenesis Regulation Of Ruffle Assembly Negative Regulation Of Potassium Ion Transmembrane Transport Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Protein Localization To Basolateral Plasma Membrane Positive Regulation Of Gap Junction Assembly Positive Regulation Of ERAD Pathway Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Anoikis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Lysosphingolipid and LPA receptors Interleukin-4 and Interleukin-13 signaling Potential therapeutics for SARS	Triglyceride catabolism eNOS activation NOSTRIN mediated eNOS trafficking Thyroxine biosynthesis Basigin interactions Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability RHOA GTPase cycle Extra-nuclear estrogen signaling RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle FOXO-mediated transcription of cell cycle genes RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Drugs		Fingolimod Ponesimod Siponimod Ozanimod
Diseases			Congenital generalized lipodystrophy (CGL)
GWAS		Irritable bowel syndrome ( 29673008) Lymphocyte count ( 27863252 29403010 32888494) Lymphocyte percentage of white cells ( 32888494) Multiple sclerosis and C-reactive protein levels (pleiotropy) ( 26920376) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Sensorimotor dexterity ( 31596458) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)	Atrial fibrillation ( 33990960 22544366 30061737 29892015 28416822) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 20062063 25055868) Electrocardiographic traits (multivariate) ( 32602732) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 25173105 29891935 33627673 20835238) Heart rate increase in response to exercise ( 29497042) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 27863252 32888494) Intraocular pressure ( 29235454 25173106 28073927 29617998) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte percentage of white cells ( 32888494) P wave duration ( 28794112) Platelet distribution width ( 32888494) PR interval ( 20062060 25035420 32439900 30679814 23139255 30046033 29127183) PR segment duration ( 24850809) Proportion of activated microglia (inferior temporal cortex) ( 30679421) QRS duration ( 30012220) QT interval ( 29874175 24952745) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		9 interacting genes: AKT1 APP CAV1 CMSS1 GNAI1 GNAI3 HTR1A HTR1D PDGFRB	86 interacting genes: ABCB1 ABL1 AKAP1 APP AR BMX BSG BST1 BTK CAV2 CD40 CSK CSNK2A1 CSNK2A2 DAG1 DANCR DNM1 EDNRB EGFR ERBB2 ESR1 FLNA FLOT2 FYN GJA1 GJA3 GJB2 GLP1R GNAI2 GRB7 GRK1 GRK2 GRK5 HRAS HTR1F IGF1R IGFBP3 ILK INSR IRS1 KCNA3 KDR LRP1 MALL MAPK1 MAPK3 MMP14 NEU3 NGFR NOS2 NOS3 NTRK1 PDGFRA PDGFRB PLD1 PLD2 PPP1CA PPP2CA PRNP PTEN PTGS2 PTPN1 PTPN11 PTPN6 PTPRF RAC1 RCVRN RHOA RHOC S1PR1 SCP2 SNCA SOS1 SRC STOML3 STRN STRN4 TEK TGFBR1 TNFRSF1B TRAF2 TRAF4 TRAF6 TRPC1 USP7 VAV2
Entrez ID		1901	857
HPRD ID		03578	03028
Ensembl ID		ENSG00000170989	ENSG00000105974
Uniprot IDs		P21453	A9XTE5 Q03135 Q2TNI1 Q59E85 Q7Z4F3
PDB IDs		3V2W 3V2Y 7EO2 7EO4 7EVY 7EVZ 7EW0 7EW7 7TD3 7TD4 7VIE 7VIF 7VIG 7VIH 7WF7 8G94 8YIC	7SC0
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Gi/o-coupled Serotonin Receptor Activity Regulation Of Nitric Oxide Metabolic Process G Protein-coupled Receptor Binding Cellular Response To Growth Factor Stimulus Peptidase Activator Activity Regulation Of Response To Endoplasmic Reticulum Stress Response To Growth Factor Regulation Of Small Molecule Metabolic Process Serotonin Receptor Activity Regulation Of Metal Ion Transport G Protein-coupled Serotonin Receptor Activity Enzyme Binding Guanyl Nucleotide Binding Neurotransmitter Receptor Activity Regulation Of Transport Positive Regulation Of Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size G-protein Beta/gamma-subunit Complex Binding Positive Regulation Of Small Molecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Prostaglandin E Cell Cortex Reactive Nitrogen Species Metabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Cholesterol Metabolic Process Regulation Of Locomotion Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Cholesterol Biosynthetic Process Nitric Oxide Metabolic Process Signal Transduction Positive Regulation Of Monoatomic Ion Transport Regulation Of System Process Vasoconstriction Positive Regulation Of Proteolysis Plasma Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Cell Motility Response To Ketone	Regulation Of Signal Transduction Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Regulation Of Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Locomotion Regulation Of Cell Motility Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of MAPK Cascade Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Intracellular Signal Transduction Positive Regulation Of Locomotion Regulation Of Multicellular Organismal Process Membrane Raft Regulation Of Cellular Component Organization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Kinase Activity Protein Tyrosine Kinase Activity Positive Regulation Of MAPK Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Oxygen-containing Compound Regulation Of Programmed Cell Death Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Intracellular Signaling Cassette Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Biological Quality Kinase Activity Protein Phosphorylation Regulation Of Transport Regulation Of Protein Metabolic Process Negative Regulation Of Programmed Cell Death Membrane Anatomical Structure Morphogenesis Phosphorylation Receptor Complex Regulation Of ERK1 And ERK2 Cascade
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