S1PR1 and GNAI3

Number of citations of the paper that reports this interaction (PubMedID 8626678)
0

Data Source:
BioGRID (affinity chromatography technology, pull down, two hybrid)
HPRD (in vitro, in vivo, two hybrid)

		S1PR1	GNAI3
Description		sphingosine-1-phosphate receptor 1	G protein subunit alpha i3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Plasma Membrane External Side Of Plasma Membrane Membrane Membrane Raft Presynapse	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytosol Heterotrimeric G-protein Complex Cytoskeleton Plasma Membrane Membrane Midbody Centriolar Satellite Ciliary Basal Body Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Protein Binding Sphingosine-1-phosphate Receptor Activity Sphingolipid Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding Guanyl Nucleotide Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Angiogenesis Blood Vessel Maturation Cardiac Muscle Tissue Growth Involved In Heart Morphogenesis Sphingosine-1-phosphate Receptor Signaling Pathway Chemotaxis Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Brain Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Cell Migration Transmission Of Nerve Impulse Lamellipodium Assembly Actin Cytoskeleton Organization Regulation Of Cell Adhesion Neuron Differentiation Positive Regulation Of Cell Migration Regulation Of Bone Mineralization Leukocyte Chemotaxis Regulation Of Bone Resorption Endothelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Positive Chemotaxis Negative Regulation Of Stress Fiber Assembly Heart Trabecula Morphogenesis T Cell Migration	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Macroautophagy GTP Metabolic Process Cell Division
Pathways		Lysosphingolipid and LPA receptors Interleukin-4 and Interleukin-13 signaling Potential therapeutics for SARS	Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway ADP signalling through P2Y purinoceptor 12 G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Extra-nuclear estrogen signaling GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production
Drugs		Fingolimod Ponesimod Siponimod Ozanimod
Diseases
GWAS		Irritable bowel syndrome ( 29673008) Lymphocyte count ( 27863252 29403010 32888494) Lymphocyte percentage of white cells ( 32888494) Multiple sclerosis and C-reactive protein levels (pleiotropy) ( 26920376) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Sensorimotor dexterity ( 31596458) Sensory peripheral neuropathy in microtubule targeting agent-treated breast cancer ( 32562552)	Childhood body mass index ( 33045005) Major depressive disorder ( 20125088)
Interacting Genes		9 interacting genes: AKT1 APP CAV1 CMSS1 GNAI1 GNAI3 HTR1A HTR1D PDGFRB	45 interacting genes: AGTR2 ATP12A CCDC88A CCDC88C CCR5 CD48 CD59 CNR1 CXCR2 DRD2 DVL1 GNB2 GNB4 GPSM1 GPSM2 GPSM3 HTR1A LPAR1 MTNR1A MTNR1B NGB NUCB1 NUCB2 PCP2 PHF24 PRKAR2B PTPRU RANGAP1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS2 RGS20 RGS3 RGS5 RGS7 RIC8A S1PR1 SNCA SOX30 TSHR
Entrez ID		1901	2773
HPRD ID		03578	00765
Ensembl ID		ENSG00000170989	ENSG00000065135
Uniprot IDs		P21453	P08754
PDB IDs		3V2W 3V2Y 7EO2 7EO4 7EVY 7EVZ 7EW0 7EW7 7TD3 7TD4 7VIE 7VIF 7VIG 7VIH 7WF7 8G94 8YIC	2IHB 2ODE 2V4Z 4G5O 4G5R 4G5S 7E9H 7KH0 7RA3 7RGP 7T10 7T11 7X6I 8GVX 8JD6 8K9L 8OY1 8SZH 8SZI 8WGB 9AVL
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Gi/o-coupled Serotonin Receptor Activity Regulation Of Nitric Oxide Metabolic Process G Protein-coupled Receptor Binding Cellular Response To Growth Factor Stimulus Peptidase Activator Activity Regulation Of Response To Endoplasmic Reticulum Stress Response To Growth Factor Regulation Of Small Molecule Metabolic Process Serotonin Receptor Activity Regulation Of Metal Ion Transport G Protein-coupled Serotonin Receptor Activity Enzyme Binding Guanyl Nucleotide Binding Neurotransmitter Receptor Activity Regulation Of Transport Positive Regulation Of Cholesterol Biosynthetic Process Nitric Oxide Biosynthetic Process Blood Vessel Diameter Maintenance Regulation Of Tube Size G-protein Beta/gamma-subunit Complex Binding Positive Regulation Of Small Molecule Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Prostaglandin E Cell Cortex Reactive Nitrogen Species Metabolic Process Positive Regulation Of Catabolic Process Positive Regulation Of Cholesterol Metabolic Process Regulation Of Locomotion Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Cholesterol Biosynthetic Process Nitric Oxide Metabolic Process Signal Transduction Positive Regulation Of Monoatomic Ion Transport Regulation Of System Process Vasoconstriction Positive Regulation Of Proteolysis Plasma Membrane Positive Regulation Of Protein Catabolic Process Negative Regulation Of Protein Localization Positive Regulation Of Cell Motility Response To Ketone	G Protein-coupled Receptor Signaling Pathway G-protein Alpha-subunit Binding Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Plasma Membrane GTPase Activity GTPase Activator Activity Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling GTPase Regulator Activity GDP-dissociation Inhibitor Activity G Protein-coupled Receptor Activity G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Membrane Synapse Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Guanyl-nucleotide Exchange Factor Activity Dendrite Regulation Of GTPase Activity Cytoplasm Melatonin Receptor Activity Dendritic Spine Response To Amphetamine Positive Regulation Of GTPase Activity Signaling Receptor Complex Adaptor Activity Glutamatergic Synapse Dopamine Uptake Involved In Synaptic Transmission Cell-cell Signaling Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signaling Response To Amine Positive Regulation Of Hydrolase Activity Cell Communication Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signaling Cassette Presynapse Catecholamine Uptake Dopamine Uptake Visual Learning Presynaptic Membrane Regulation Of Blood Circulation Visual Behavior
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