GNA15 and CXCR2

Number of citations of the paper that reports this interaction (PubMedID 9843397)
0

Data Source:
HPRD (in vivo)

		GNA15	CXCR2
Description		G protein subunit alpha 15	C-X-C motif chemokine receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Synapse	Nucleoplasm Plasma Membrane External Side Of Plasma Membrane Cell Surface Microtubule Cytoskeleton Membrane Secretory Granule Membrane Mast Cell Granule Mitotic Spindle
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Interleukin-8 Receptor Activity G Protein-coupled Receptor Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-X-C Chemokine Receptor Activity C-C Chemokine Binding Interleukin-8 Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Calcium-mediated Signaling	Dendritic Cell Chemotaxis Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Cell Population Proliferation Calcium-mediated Signaling Neutrophil Chemotaxis Receptor Internalization Interleukin-8-mediated Signaling Pathway Neutrophil Activation Negative Regulation Of Apoptotic Process Chemokine-mediated Signaling Pathway
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation
Drugs
Diseases
GWAS		Asthma ( 31959851 32296059 34103634) Clozapine-induced myocarditis in schizophrenia ( 32066683) Glucose homeostasis traits ( 25524916) Heart failure ( 20445134) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 23128233 28067908) Lymphocyte percentage of white cells ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252 32888494) Neutrophil percentage of white cells ( 27863252 32888494) Smooth-surface caries ( 23470693) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252 32888494)
Interacting Genes		19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1	32 interacting genes: ADRA1A ARLN ARRB1 ATP13A1 CLDN22 CXCL1 CXCL2 CXCL3 CXCL5 CXCL6 CXCL8 CXCR1 EMP1 FKBP8 GNA14 GNA15 GNAI2 GNAI3 GPRASP1 GRIA1 MYO5B PPBP PPP2CA RAB11FIP2 RGS12 SLC18A2 SLC39A2 SMCO4 ST13 TMEM147 TMEM80 TRARG1
Entrez ID		2769	3579
HPRD ID		00760	00907
Ensembl ID		ENSG00000060558	ENSG00000180871
Uniprot IDs		P30679	P25025 Q53PC4
PDB IDs			4Q3H 5TYT 6KVA 6KVF 6LFM 6LFO 8XVU 8XWA 8XWF 8XWM 8XWN 8XWS 8XWV 8XX3 8XX6 8XX7 8XXH 8XXR 8XXX
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Trans-synaptic Signaling Synaptic Signaling Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Cell-cell Signaling G Protein-coupled Acetylcholine Receptor Signaling Pathway Signaling Regulation Of MAPK Cascade Cell Communication G Protein-coupled Opioid Receptor Activity Regulation Of System Process Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Peptide Receptor Activity G Protein-coupled Opioid Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Regulation Of Muscle System Process Postsynaptic Signal Transduction Regulation Of Biological Quality Glutamate Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Dendrite Adult Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Smooth Muscle Contraction Modulation Of Chemical Synaptic Transmission Membrane Chemical Synaptic Transmission Regulation Of Muscle Contraction Cannabinoid Receptor Activity Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Negative Regulation Of Muscle Contraction Regulation Of Amine Transport Neuronal Dense Core Vesicle Regulation Of Transport Neuropeptide Binding Synapse Cannabinoid Signaling Pathway Interleukin-8 Binding G-protein Alpha-subunit Binding Presynapse Neuropeptide Signaling Pathway	Chemokine Activity Neutrophil Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Neutrophil Migration Cell Chemotaxis Granulocyte Chemotaxis CXCR Chemokine Receptor Binding Antimicrobial Humoral Response Granulocyte Migration Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Chemotaxis Cytokine Activity Myeloid Leukocyte Migration Locomotion Leukocyte Chemotaxis G Protein-coupled Receptor Binding Heterotrimeric G-protein Complex Humoral Immune Response G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Killing Of Cells Of Another Organism Leukocyte Migration Inflammatory Response Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Killing Signal Transduction Import Into Cell Signaling Endocytosis Negative Regulation Of Adenylate Cyclase Activity Cell Communication Cell Migration Calcium-mediated Signaling Cytoplasmic Vesicle Membrane GTPase Activity Receptor-mediated Endocytosis Cellular Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Defense Response To Symbiont Defense Response To Other Organism Cellular Response To Molecule Of Bacterial Origin Cell Motility G Protein-coupled Acetylcholine Receptor Signaling Pathway Cell-cell Signaling Response To Other Organism Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vesicle-mediated Transport Plasma Membrane
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