GNA15 and OPRK1

Number of citations of the paper that reports this interaction (PMID 9572309)
8

Data Source:
HPRD (in vivo)

		GNA15	OPRK1
Gene Name		guanine nucleotide binding protein (G protein), alpha 15 (Gq class)	opioid receptor, kappa 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Neuron Projection
	Molecular Function	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Opioid Receptor Activity Protein Binding Dynorphin Receptor Activity Neuropeptide Binding
	Biological Process	Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Blood Coagulation Platelet Activation Phospholipase C-activating Dopamine Receptor Signaling Pathway	Immune Response Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Synaptic Transmission Sensory Perception Behavior Locomotory Behavior Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Opioid Receptor Signaling Pathway Regulation Of Saliva Secretion Defense Response To Virus
Pathways		G alpha (q) signalling events Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Signaling by GPCR ADP signalling through P2Y purinoceptor 1 Integration of energy metabolism Regulation of insulin secretion Signal amplification Thrombin signalling through proteinase activated receptors (PARs) G alpha (q) signalling events GPCR downstream signaling Acetylcholine regulates insulin secretion Gastrin-CREB signalling pathway via PKC and MAPK Thromboxane signalling through TP receptor Platelet activation, signaling and aggregation Free fatty acids regulate insulin secretion	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Tramadol Morphine Codeine Amitriptyline Hydromorphone Mirtazapine Meperidine Oxycodone Butorphanol Propoxyphene Pentazocine Naltrexone Sufentanil Fentanyl Menthol Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Naloxone Dezocine 3-Methylthiofentanyl Heroin Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl Tapentadol Alvimopan Methylnaltrexone
Diseases
GWAS		Heart failure ( 20445134)
Protein-Protein Interactions		19 interactors: ADRB2 ADRBK1 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1	5 interactors: GABARAPL1 GNA15 GPRASP1 OPRD1 SLC9A3R1
Entrez ID		2769	4986
HPRD ID		00760	01309
Ensembl ID		ENSG00000060558	ENSG00000082556
Uniprot IDs		P30679	P41145
PDB IDs			2A0D 2IQN 4DJH
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction Defense Response Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Signaling Cell Communication Sensory Perception Of Pain Cellular Metal Ion Homeostasis Inflammatory Response Response To External Stimulus Opioid Receptor Signaling Pathway Cellular Cation Homeostasis Cellular Response To Stimulus Cellular Ion Homeostasis Metal Ion Homeostasis Regulation Of Phosphorus Metabolic Process Cellular Chemical Homeostasis Blood Circulation Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Muscle Contraction Response To Stress Chemical Homeostasis Ion Homeostasis Synaptic Transmission Regulation Of Cyclase Activity Immune Response Regulation Of Phosphorylation Cytosolic Calcium Ion Homeostasis Regulation Of MAPK Cascade Regulation Of Catalytic Activity Homeostatic Process Regulation Of Signaling Interleukin-8-mediated Signaling Pathway Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Cellular Homeostasis Negative Regulation Of Muscle Contraction Negative Regulation Of Adenylate Cyclase Activity Regulation Of CAMP Biosynthetic Process Negative Regulation Of Lyase Activity Response To Stimulus Regulation Of CAMP Metabolic Process Regulation Of Sensory Perception Of Pain Negative Regulation Of Catalytic Activity	Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Dopamine Receptor Signaling Pathway Renal Phosphate Ion Absorption Glutathione Transport G-protein Coupled Receptor Catabolic Process Negative Regulation Of Sodium:proton Antiporter Activity Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Renal Sodium Ion Transport G-protein Coupled Receptor Signaling Pathway Cellular Phosphate Ion Homeostasis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium Ion Transmembrane Transport Negative Regulation Of Protein Oligomerization Bile Acid Secretion Opioid Receptor Signaling Pathway Oligopeptide Transport Negative Regulation Of Sodium Ion Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Renal Absorption Regulation Of Proton Transport Phosphate Ion Homeostasis G-protein Coupled Acetylcholine Receptor Signaling Pathway Microvillus Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Microvillus Organization Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Cellular Ion Homeostasis Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of CREB Transcription Factor Activity Receptor Catabolic Process Nucleophagy Cellular Chemical Homeostasis Cellular Response To Toxic Substance Regulation Of Excretion Ion Homeostasis Regulation Of Sensory Perception Of Pain Mitochondrion Degradation Regulation Of Protein Oligomerization Regulation Of Sodium Ion Transmembrane Transporter Activity Protein Import Into Nucleus, Translocation Endosome To Lysosome Transport Regulation Of Ion Transport Bile Acid And Bile Salt Transport Regulation Of Mitochondrial Membrane Potential Regulation Of Sodium Ion Transmembrane Transport Cytoplasmic Transport
Tagcloud ?			anomalies behind bioinformatics cart ctf dependence depicting ebpbeta elaborate govern instance intron likewise modify nfya nutshell pdyn pdyns pharmaceutical prodynorphin prompting regimes retrieve snps tbp usf usf2 vdr vulnerability
Tagcloud (Difference) ?			anomalies behind bioinformatics cart ctf dependence depicting ebpbeta elaborate govern instance intron likewise modify nfya nutshell pdyn pdyns pharmaceutical prodynorphin prompting regimes retrieve snps tbp usf usf2 vdr vulnerability
Tagcloud (Intersection) ?