GNA15 and OPRK1

Number of citations of the paper that reports this interaction (PubMedID 9572309)
0

Data Source:
HPRD (in vivo)

		GNA15	OPRK1
Description		G protein subunit alpha 15	opioid receptor kappa 1
Image		No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Synapse	Nucleoplasm Mitochondrion Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum T-tubule Dendrite Synaptic Vesicle Membrane Sarcolemma Presynaptic Membrane Neuron Projection Neuronal Cell Body Perikaryon Axon Terminus Postsynaptic Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Receptor Serine/threonine Kinase Binding Dynorphin Receptor Activity Neuropeptide Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Calcium-mediated Signaling	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Sensory Perception Locomotory Behavior Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Insulin Positive Regulation Of Dopamine Secretion Negative Regulation Of Luteinizing Hormone Secretion Response To Nicotine G Protein-coupled Opioid Receptor Signaling Pathway Response To Cocaine Maternal Behavior Eating Behavior Response To Estrogen Estrous Cycle Response To Ethanol Regulation Of Saliva Secretion Behavioral Response To Cocaine Sensory Perception Of Temperature Stimulus Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Glucose Stimulus Positive Regulation Of P38MAPK Cascade Positive Regulation Of Potassium Ion Transmembrane Transport Response To Acrylamide Positive Regulation Of Eating Behavior Conditioned Place Preference
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates neuronal receptors and channels
Drugs			Tramadol Atomoxetine Morphine Codeine Amitriptyline Hydromorphone Mirtazapine Progesterone Meperidine Oxycodone Dextromethorphan Lamotrigine Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Fentanyl Levomenthol Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Naloxone Dezocine Ketamine Aripiprazole 3-Methylthiofentanyl Diamorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Asimadoline CR665 ADL 10-0101 Mianserin Tapentadol Nalmefene Alvimopan Amisulpride Morphine glucuronide Ketobemidone Methylnaltrexone Butyrfentanyl Pholcodine Eluxadoline Opium Pentoxyverine Naldemedine Difelikefalin Samidorphan Loxicodegol
Diseases
GWAS		Asthma ( 31959851 32296059 34103634) Clozapine-induced myocarditis in schizophrenia ( 32066683) Glucose homeostasis traits ( 25524916) Heart failure ( 20445134) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)	Age at first sexual intercourse ( 34211149) Body size at age 10 ( 32376654) IgE levels in asthmatics (D.p. specific) ( 23967269) Modic changes ( 30808802) Systolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373)
Interacting Genes		19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1	6 interacting genes: GABARAPL1 GNA15 GPRASP1 NHERF1 NKG7 OPRD1
Entrez ID		2769	4986
HPRD ID		00760	01309
Ensembl ID		ENSG00000060558	ENSG00000082556
Uniprot IDs		P30679	A0A5F9ZI09 P41145
PDB IDs			4DJH 6B73 6VI4 7T10 7T11 7UL2 7UL3 7UL5 7Y1F 7YIT 7YMJ 8DZP 8DZQ 8DZR 8DZS 8F7W 8FEG 8HNN 8K2W 8VVE 8VVF 8VVG 9D61
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Trans-synaptic Signaling Synaptic Signaling Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Cell-cell Signaling G Protein-coupled Acetylcholine Receptor Signaling Pathway Signaling Regulation Of MAPK Cascade Cell Communication G Protein-coupled Opioid Receptor Activity Regulation Of System Process Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Peptide Receptor Activity G Protein-coupled Opioid Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Regulation Of Muscle System Process Postsynaptic Signal Transduction Regulation Of Biological Quality Glutamate Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Dendrite Adult Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Smooth Muscle Contraction Modulation Of Chemical Synaptic Transmission Membrane Chemical Synaptic Transmission Regulation Of Muscle Contraction Cannabinoid Receptor Activity Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Negative Regulation Of Muscle Contraction Regulation Of Amine Transport Neuronal Dense Core Vesicle Regulation Of Transport Neuropeptide Binding Synapse Cannabinoid Signaling Pathway Interleukin-8 Binding G-protein Alpha-subunit Binding Presynapse Neuropeptide Signaling Pathway	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target G Protein-coupled Enkephalin Receptor Activity Renal Phosphate Ion Absorption Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding G Protein-coupled Receptor Catabolic Process Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Natural Killer Cell Degranulation Cytolytic Granule Membrane Immune Response To Tumor Cell Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vesicle Receptor Serine/threonine Kinase Binding G Protein-coupled Opioid Receptor Activity Spine Apparatus Microvillus Organization Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Type 3 Metabotropic Glutamate Receptor Binding Establishment Of Golgi Localization Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Phospholipase C-activating Dopamine Receptor Signaling Pathway Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding G Protein-coupled Opioid Receptor Signaling Pathway Intracellular Phosphate Ion Homeostasis Cytolytic Granule Granzyme-mediated Programmed Cell Death Signaling Pathway Cellular Response To Toxic Substance Negative Regulation Of Sodium Ion Transport Gamma-aminobutyric Acid Transport Golgi Localization Maintenance Of Cell Polarity Glutathione Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibroblast Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cerebrospinal Fluid Circulation Phosphatidylethanolamine Binding Cellular Response To Nitrogen Starvation Tat Protein Binding Glycophagy Plasma Membrane Protein Complex
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