GNA15 and GRM4

Number of citations of the paper that reports this interaction (PubMedID 8863838)
0

Data Source:
HPRD (in vivo)

		GNA15	GRM4
Description		G protein subunit alpha 15	glutamate metabotropic receptor 4
Image		No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Synapse	Plasma Membrane Membrane Cytoplasmic Vesicle Synapse Presynapse
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Glutamate Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Calcium-mediated Signaling	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Neurotransmitter Secretion Positive Regulation Of MAPK Cascade Regulation Of Neuron Apoptotic Process Regulation Of Synaptic Transmission, Glutamatergic
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs			Glutamic acid
Diseases
GWAS		Asthma ( 31959851 32296059 34103634) Clozapine-induced myocarditis in schizophrenia ( 32066683) Glucose homeostasis traits ( 25524916) Heart failure ( 20445134) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil count ( 32888494) White blood cell count ( 32888494)	A body shape index ( 34021172) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Appendicular lean mass ( 33097823) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) BMI at birth ( 31575865) Body mass index ( 26426971 28892062) Childhood body mass index ( 33045005) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Height ( 34054925) Hip circumference adjusted for BMI ( 34021172) Inflammatory skin disease ( 25574825) Monocyte count ( 32888494) Osteosarcoma ( 23727862) Pulse pressure ( 30578418) Regular attendance at a gym or sports club ( 29970889) Tonsillectomy ( 28928442 27182965) Uterine fibroids ( 31649266) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 34054925)
Interacting Genes		19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1	4 interacting genes: CALM1 FLNA GNA15 GNAQ
Entrez ID		2769	2914
HPRD ID		00760	04978
Ensembl ID		ENSG00000060558	ENSG00000124493
Uniprot IDs		P30679	A1L4F9 A8K0J8 B7ZLU9 Q14833
PDB IDs			7E9H 8JD4 8JD5 8JD6 8WG9 8WGB 8WGC 8WGD
Enriched GO Terms of Interacting Partners?		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Trans-synaptic Signaling Synaptic Signaling Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Cell-cell Signaling G Protein-coupled Acetylcholine Receptor Signaling Pathway Signaling Regulation Of MAPK Cascade Cell Communication G Protein-coupled Opioid Receptor Activity Regulation Of System Process Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Peptide Receptor Activity G Protein-coupled Opioid Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Regulation Of Muscle System Process Postsynaptic Signal Transduction Regulation Of Biological Quality Glutamate Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Dendrite Adult Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Smooth Muscle Contraction Modulation Of Chemical Synaptic Transmission Membrane Chemical Synaptic Transmission Regulation Of Muscle Contraction Cannabinoid Receptor Activity Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Negative Regulation Of Muscle Contraction Regulation Of Amine Transport Neuronal Dense Core Vesicle Regulation Of Transport Neuropeptide Binding Synapse Cannabinoid Signaling Pathway Interleukin-8 Binding G-protein Alpha-subunit Binding Presynapse Neuropeptide Signaling Pathway	G Protein-coupled Receptor Binding Transmembrane Transporter Binding Regulation Of Cell Communication By Electrical Coupling G Protein-coupled Acetylcholine Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Transporter Activity G Protein-coupled Receptor Signaling Pathway Regulation Of Monoatomic Cation Transmembrane Transport Heterotrimeric G-protein Complex Regulation Of Monoatomic Ion Transmembrane Transport Acetylcholine Receptor Signaling Pathway Regulation Of Metal Ion Transport Postsynaptic Signal Transduction Regulation Of Platelet Activation Regulation Of Action Potential Regulation Of Monoatomic Ion Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Cation Transmembrane Transport Negative Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Potassium Ion Transport Regulation Of Membrane Repolarization During Atrial Cardiac Muscle Cell Action Potential Negative Regulation Of Monoatomic Ion Transport Negative Regulation Of Transmembrane Transport Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Maintenance Of Protein Location In Plasma Membrane Regulation Of Sequestering Of Calcium Ion Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Z Disc Positive Regulation Of Cell Communication By Electrical Coupling Fc-gamma Receptor I Complex Binding Tubulin Deacetylation Myb Complex Signal Transduction Calcium-mediated Signaling Positive Regulation Of Monoatomic Ion Transport Formation Of Radial Glial Scaffolds Establishment Of Sertoli Cell Barrier Protein Localization To Plasma Membrane Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Plasma Membrane Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Negative Regulation Of Calcium Ion Export Across Plasma Membrane Adenylate Cyclase Activator Activity Glycoprotein Ib-IX-V Complex
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