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GNA15 and F2R
Number of citations of the paper that reports this interaction (PMID
10644723
)
6
Data Source:
HPRD
(in vitro)
GNA15
F2R
Gene Name
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
coagulation factor II (thrombin) receptor
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Heterotrimeric G-protein Complex
Plasma Membrane
Extracellular Region
Early Endosome
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
Platelet Dense Tubular Network
Neuromuscular Junction
Postsynaptic Membrane
Molecular Function
G-protein Coupled Receptor Binding
GTPase Activity
Signal Transducer Activity
GTP Binding
G-protein Beta/gamma-subunit Complex Binding
Metal Ion Binding
G-protein Alpha-subunit Binding
G-protein Coupled Receptor Activity
Receptor Binding
Protein Binding
Thrombin Receptor Activity
G-protein Beta-subunit Binding
Biological Process
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway
Blood Coagulation
Platelet Activation
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Activation Of MAPKK Activity
Connective Tissue Replacement Involved In Inflammatory Response Wound Healing
Negative Regulation Of Glomerular Filtration
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Response
G-protein Coupled Receptor Signaling Pathway
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway
Tyrosine Phosphorylation Of STAT Protein
STAT Protein Import Into Nucleus
Establishment Of Synaptic Specificity At Neuromuscular Junction
Blood Coagulation
Positive Regulation Of Cell Proliferation
Negative Regulation Of Cell Proliferation
Response To Wounding
Anatomical Structure Morphogenesis
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Platelet Activation
Regulation Of Blood Coagulation
Positive Regulation Of Blood Coagulation
Positive Regulation Of Cell Migration
Response To Lipopolysaccharide
Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Rho Protein Signal Transduction
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Vasoconstriction
Positive Regulation Of Smooth Muscle Contraction
Positive Regulation Of JAK-STAT Cascade
Homeostasis Of Number Of Cells Within A Tissue
Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway
Positive Regulation Of Calcium Ion Transport
Regulation Of Sensory Perception Of Pain
Platelet Dense Granule Organization
Positive Regulation Of ERK1 And ERK2 Cascade
Thrombin Receptor Signaling Pathway
Negative Regulation Of Renin Secretion Into Blood Stream
Positive Regulation Of Interleukin-8 Secretion
Positive Regulation Of Interleukin-6 Secretion
Pathways
G alpha (q) signalling events
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Signaling by GPCR
ADP signalling through P2Y purinoceptor 1
Integration of energy metabolism
Regulation of insulin secretion
Signal amplification
Thrombin signalling through proteinase activated receptors (PARs)
G alpha (q) signalling events
GPCR downstream signaling
Acetylcholine regulates insulin secretion
Gastrin-CREB signalling pathway via PKC and MAPK
Thromboxane signalling through TP receptor
Platelet activation, signaling and aggregation
Free fatty acids regulate insulin secretion
Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD)
G alpha (q) signalling events
Signaling by GPCR
Class A/1 (Rhodopsin-like receptors)
Metabolic disorders of biological oxidation enzymes
GPCR ligand binding
Formation of Fibrin Clot (Clotting Cascade)
Common Pathway
G alpha (q) signalling events
Thrombin signalling through proteinase activated receptors (PARs)
GPCR downstream signaling
Peptide ligand-binding receptors
Gastrin-CREB signalling pathway via PKC and MAPK
Platelet activation, signaling and aggregation
Drugs
Streptokinase
Diseases
GWAS
Heart failure (
20445134
)
Mean platelet volume (
22139419
)
Platelet counts (
22139419
)
Protein-Protein Interactions
19 interactors:
ADRB2
ADRBK1
APP
CHRM2
CNR1
CNR2
CXCR1
CXCR2
F2R
GRM2
GRM4
HRH4
LTB4R
OPRD1
OPRK1
OPRM1
PRKCA
RGS2
TTC1
17 interactors:
ATP13A2
CAPN1
CHRD
CTSG
ELANE
F2
GNA12
GNA13
GNA15
GNAI2
GNAT1
GPRASP1
ITGAV
PDCD6IP
PLG
PRTN3
SNX1
Entrez ID
2769
2149
HPRD ID
00760
01763
Ensembl ID
ENSG00000060558
ENSG00000181104
Uniprot IDs
P30679
P25116
Q2TNB2
PDB IDs
1NRN
1NRO
1NRP
1NRQ
1NRR
3BEF
3HKI
3HKJ
3LU9
3VW7
Enriched GO Terms of Interacting Partners
?
G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Defense Response
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Cellular Calcium Ion Homeostasis
Calcium Ion Homeostasis
Signaling
Cell Communication
Sensory Perception Of Pain
Cellular Metal Ion Homeostasis
Inflammatory Response
Response To External Stimulus
Opioid Receptor Signaling Pathway
Cellular Cation Homeostasis
Cellular Response To Stimulus
Cellular Ion Homeostasis
Metal Ion Homeostasis
Regulation Of Phosphorus Metabolic Process
Cellular Chemical Homeostasis
Blood Circulation
Regulation Of Adenylate Cyclase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Muscle Contraction
Response To Stress
Chemical Homeostasis
Ion Homeostasis
Synaptic Transmission
Regulation Of Cyclase Activity
Immune Response
Regulation Of Phosphorylation
Cytosolic Calcium Ion Homeostasis
Regulation Of MAPK Cascade
Regulation Of Catalytic Activity
Homeostatic Process
Regulation Of Signaling
Interleukin-8-mediated Signaling Pathway
Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway
Cellular Homeostasis
Negative Regulation Of Muscle Contraction
Negative Regulation Of Adenylate Cyclase Activity
Regulation Of CAMP Biosynthetic Process
Negative Regulation Of Lyase Activity
Response To Stimulus
Regulation Of CAMP Metabolic Process
Regulation Of Sensory Perception Of Pain
Negative Regulation Of Catalytic Activity
Blood Coagulation
Hemostasis
Regulation Of Body Fluid Levels
Wound Healing
Platelet Activation
Response To Wounding
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Extracellular Matrix Disassembly
Positive Regulation Of Cell Proliferation
Regulation Of Cell Proliferation
Extracellular Matrix Organization
Extracellular Structure Organization
Cell Activation
Killing By Host Of Symbiont Cells
Leukocyte Migration
Receptor Metabolic Process
Negative Regulation Of Fibrinolysis
Response To Stress
Receptor Catabolic Process
Regulation Of Fibrinolysis
Proteolysis
G-protein Coupled Acetylcholine Receptor Signaling Pathway
Cellular Calcium Ion Homeostasis
Calcium Ion Homeostasis
Regulation Of Locomotion
Cellular Homeostasis
Neutrophil Mediated Immunity
Killing Of Cells Of Other Organism
Cellular Metal Ion Homeostasis
Negative Regulation Of Growth Of Symbiont In Host
Defense Response To Fungus
Regulation Of Cell Shape
Fibrinolysis
Cellular Cation Homeostasis
Positive Regulation Of Blood Coagulation
Cellular Ion Homeostasis
Regulation Of G-protein Coupled Receptor Protein Signaling Pathway
Interaction With Symbiont
Leukocyte Mediated Cytotoxicity
Cytosolic Calcium Ion Homeostasis
Metal Ion Homeostasis
Regulation Of Signal Transduction
Positive Regulation Of Coagulation
Response To Fungus
Regulation Of Protein Metabolic Process
Cellular Chemical Homeostasis
Response To Stimulus
Positive Regulation Of Wound Healing
Ion Homeostasis
Tagcloud
?
agt
card4
casp1
csf2
csf3
curcuma
icam1
ifng
ikbkb
ikbke
il10
il1a
il1b
il8
impressive
irak2
longa
map3k1
nfkb1
nfkb2
nfkbia
ppm1a
raf1
relb
ticam1
ticam2
tnfalphaip3
tnfrsf7
tnfsf10
Tagcloud (Difference)
?
agt
card4
casp1
csf2
csf3
curcuma
icam1
ifng
ikbkb
ikbke
il10
il1a
il1b
il8
impressive
irak2
longa
map3k1
nfkb1
nfkb2
nfkbia
ppm1a
raf1
relb
ticam1
ticam2
tnfalphaip3
tnfrsf7
tnfsf10
Tagcloud (Intersection)
?