GNA15 and F2R

Number of citations: 0 (PubMedID 10644723)
Data Source: HPRD (in vitro)

		GNA15	F2R
Name		G protein subunit alpha 15	coagulation factor II thrombin receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Synapse	Extracellular Region Early Endosome Late Endosome Golgi Apparatus Plasma Membrane Caveola Cell Surface Membrane Platelet Dense Tubular Network Neuromuscular Junction Postsynaptic Membrane
	Molecular Function	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity GTP Binding Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Protein Binding Thrombin-activated Receptor Activity G-protein Beta-subunit Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Calcium-mediated Signaling	Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Negative Regulation Of Glomerular Filtration Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Establishment Of Synaptic Specificity At Neuromuscular Junction Blood Coagulation Hemostasis Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Wounding Anatomical Structure Morphogenesis Glutamate Secretion Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Rho Protein Signal Transduction Dendritic Cell Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Cell-cell Junction Maintenance Positive Regulation Of DNA-templated Transcription Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Synaptic Plasticity Homeostasis Of Number Of Cells Within A Tissue Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Calcium Ion Transport Platelet Dense Granule Organization Regulation Of Biological Quality Positive Regulation Of ERK1 And ERK2 Cascade Thrombin-activated Receptor Signaling Pathway Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Negative Regulation Of Renin Secretion Into Blood Stream
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Common Pathway of Fibrin Clot Formation Peptide ligand-binding receptors G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs)
Drugs		None	Streptokinase SR-123781A Vorapaxar Thrombin
GWAS		Asthma ( 31959851 32296059 34103634 ) Clozapine-induced myocarditis in schizophrenia ( 32066683 ) Glucose homeostasis traits ( 25524916 ) Heart failure ( 20445134 ) Mean corpuscular volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Neutrophil count ( 32888494 ) White blood cell count ( 32888494 )	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690 ) Erosive tooth wear (severe vs non-severe) ( 29898447 ) Erosive tooth wear (severe vs none or mild) ( 29898447 ) Mean platelet volume ( 22139419 ) Platelet count ( 22139419 ) Platelet distribution width ( 27863252 )
Interacting Genes		19 interacting genes: ADRB2 APP CHRM2 CNR1 CNR2 CXCR1 CXCR2 F2R GRK2 GRM2 GRM4 HRH4 LTB4R OPRD1 OPRK1 OPRM1 PRKCA RGS2 TTC1	19 interacting genes: ATP13A2 CAPN1 CHRD CTSG CXCL14 ELANE F2 GNA12 GNA13 GNA15 GNAI2 GNAT1 GPRASP1 ITGAV PDCD6IP PLG PRTN3 SNCA SNX1
Entrez ID		2769	2149
HPRD ID		00760	01763
Ensembl ID		ENSG00000060558	ENSG00000181104
Uniprot IDs		P30679	P25116
PDB IDs		Not available	1NRN 1NRO 1NRP 1NRQ 1NRR 3BEF 3HKI 3HKJ 3LU9 3VW7 8XOR 8XOS
GO Terms Enriched among Interactors		G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Trans-synaptic Signaling Synaptic Signaling Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Cell-cell Signaling G Protein-coupled Acetylcholine Receptor Signaling Pathway Signaling Regulation Of MAPK Cascade Cell Communication G Protein-coupled Opioid Receptor Activity Regulation Of System Process Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Peptide Receptor Activity G Protein-coupled Opioid Receptor Signaling Pathway Acetylcholine Receptor Signaling Pathway Postsynaptic Membrane Regulation Of Muscle System Process Postsynaptic Signal Transduction Regulation Of Biological Quality Glutamate Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Dendrite Adult Behavior Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Smooth Muscle Contraction Modulation Of Chemical Synaptic Transmission Membrane Chemical Synaptic Transmission Regulation Of Muscle Contraction Cannabinoid Receptor Activity Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Interleukin-8-mediated Signaling Pathway Interleukin-8 Receptor Activity Negative Regulation Of Muscle Contraction Regulation Of Amine Transport Neuronal Dense Core Vesicle Regulation Of Transport Neuropeptide Binding Synapse Cannabinoid Signaling Pathway Interleukin-8 Binding G-protein Alpha-subunit Binding Presynapse Neuropeptide Signaling Pathway	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Binding Biological Process Involved In Interaction With Symbiont Neutrophil-mediated Killing Of Bacterium Serine-type Peptidase Activity Serine-type Endopeptidase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Locomotion D5 Dopamine Receptor Binding Extracellular Exosome Biogenesis Regulation Of Vesicle-mediated Transport Neutrophil Mediated Immunity Regulation Of Exocytosis Positive Regulation Of Exocytosis Leukocyte Migration Killing By Host Of Symbiont Cells Coagulation Blood Coagulation Regulation Of Cell Migration Protease Binding Hemostasis Extracellular Vesicle Biogenesis Peptidase Activity Regulation Of Cell Motility Killing Of Cells Of Another Organism Neutrophil-mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Regulation Of Body Fluid Levels Regulation Of Reactive Oxygen Species Metabolic Process G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Secretion By Cell Rho-activating G Protein-coupled Receptor Signaling Pathway Extracellular Matrix Disassembly Positive Regulation Of Secretion GTPase Activity Regulation Of Catalytic Activity Antimicrobial Humoral Response Extracellular Exosome Regulation Of Secretion By Cell Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Chaperone-mediated Autophagy Extracellular Region Regulation Of Biological Quality Regulation Of Cell Population Proliferation Cell Migration GTP Binding Positive Regulation Of Cell Population Proliferation