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GNA15 and PRKCA
Number of citations of the paper that reports this interaction (PMID
12647293
)
0
Data Source:
HPRD
(in vitro)
GNA15
PRKCA
Gene Name
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
protein kinase C, alpha
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Heterotrimeric G-protein Complex
Plasma Membrane
Photoreceptor Outer Segment
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Dendrite
Mitochondrial Membrane
Neuronal Cell Body
Apical Part Of Cell
Perinuclear Region Of Cytoplasm
Extracellular Vesicular Exosome
Molecular Function
G-protein Coupled Receptor Binding
GTPase Activity
Signal Transducer Activity
GTP Binding
G-protein Beta/gamma-subunit Complex Binding
Metal Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Enzyme Binding
Histone Kinase Activity (H3-T6 Specific)
Biological Process
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Activation Of Phospholipase C Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway
Blood Coagulation
Platelet Activation
Phospholipase C-activating Dopamine Receptor Signaling Pathway
Inactivation Of MAPK Activity
Mitotic Cell Cycle
Angiogenesis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Regulation Of The Force Of Heart Contraction
Chondrocyte Differentiation
Desmosome Assembly
Energy Reserve Metabolic Process
Protein Phosphorylation
Cellular Calcium Ion Homeostasis
Regulation Of Muscle Contraction
Mitotic Nuclear Envelope Disassembly
Cell Adhesion
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
Activation Of Adenylate Cyclase Activity
Negative Regulation Of Adenylate Cyclase Activity
Activation Of Phospholipase C Activity
Synaptic Transmission
Blood Coagulation
Phototransduction, Visible Light
Negative Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Gene Expression
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Cardiac Muscle Hypertrophy
Rhodopsin Mediated Signaling Pathway
Regulation Of Rhodopsin Mediated Signaling Pathway
Platelet Activation
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Neutrophil Chemotaxis
Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway
Negative Regulation Of Glial Cell Apoptotic Process
Histone H3-T6 Phosphorylation
Peptidyl-serine Autophosphorylation
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Small Molecule Metabolic Process
Innate Immune Response
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Angiogenesis
Positive Regulation Of Cell Adhesion
Positive Regulation Of Mitotic Cell Cycle
Negative Regulation Of Glucose Import
Negative Regulation Of Insulin Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Inflammatory Response
Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Insulin Secretion
Induction Of Positive Chemotaxis
Positive Regulation Of ERK1 And ERK2 Cascade
Response To Interleukin-1
Cellular Response To Carbohydrate Stimulus
Regulation Of Platelet Aggregation
Apoptotic Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Dense Core Granule Biogenesis
Pathways
G alpha (q) signalling events
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
Signaling by GPCR
ADP signalling through P2Y purinoceptor 1
Integration of energy metabolism
Regulation of insulin secretion
Signal amplification
Thrombin signalling through proteinase activated receptors (PARs)
G alpha (q) signalling events
GPCR downstream signaling
Acetylcholine regulates insulin secretion
Gastrin-CREB signalling pathway via PKC and MAPK
Thromboxane signalling through TP receptor
Platelet activation, signaling and aggregation
Free fatty acids regulate insulin secretion
Ca-dependent events
Signaling by GPCR
CaM pathway
Signaling by FGFR in disease
Phospholipase C-mediated cascade
Integration of energy metabolism
Mitotic Prophase
Signaling by Wnt
Signaling by EGFRvIII in Cancer
PLCG1 events in ERBB2 signaling
Signaling by SCF-KIT
DAP12 signaling
Regulation of KIT signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Response to elevated platelet cytosolic Ca2+
G alpha (z) signalling events
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Signaling by PDGF
Calmodulin induced events
DAP12 interactions
Regulation of mRNA stability by proteins that bind AU-rich elements
Opioid Signalling
Diseases associated with visual transduction
EGFR interacts with phospholipase C-gamma
Signaling by ERBB2
Signaling by EGFR
Syndecan interactions
GPCR downstream signaling
Signaling by VEGF
Calmodulin induced events
Downstream signal transduction
WNT5A-dependent internalization of FZD4
Signaling by EGFR in Cancer
Platelet activation, signaling and aggregation
PCP/CE pathway
Transmission across Chemical Synapses
Trafficking of GluR2-containing AMPA receptors
Nuclear Envelope Breakdown
HuR stabilizes mRNA
DAG and IP3 signaling
M Phase
VEGFA-VEGFR2 Pathway
CaM pathway
Inactivation, recovery and regulation of the phototransduction cascade
EGFR Transactivation by Gastrin
VEGFR2 mediated cell proliferation
Downstream signaling of activated FGFR
The phototransduction cascade
Disinhibition of SNARE formation
Innate Immune System
Signalling by NGF
PLC beta mediated events
Regulation of insulin secretion
Depolymerisation of the Nuclear Lamina
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
G-protein mediated events
Non-integrin membrane-ECM interactions
Signaling by Overexpressed Wild-Type EGFR in Cancer
Trafficking of AMPA receptors
Cell Cycle, Mitotic
Signaling by FGFR
beta-catenin independent WNT signaling
Acetylcholine regulates insulin secretion
Visual phototransduction
Ca2+ pathway
PLC-gamma1 signalling
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
Drugs
Phosphatidylserine
Vitamin E
Ingenol Mebutate
Ellagic Acid
Diseases
GWAS
Heart failure (
20445134
)
Height (
22021425
)
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Ventricular conduction (
21076409
)
Protein-Protein Interactions
19 interactors:
ADRB2
ADRBK1
APP
CHRM2
CNR1
CNR2
CXCR1
CXCR2
F2R
GRM2
GRM4
HRH4
LTB4R
OPRD1
OPRK1
OPRM1
PRKCA
RGS2
TTC1
210 interactors:
ACTA1
ADAP1
ADCY5
ADD3
ADRA1B
ADRBK1
AFAP1
AKAP12
AKAP5
ANXA2
ANXA7
APLP2
ARHGEF1
ATP1A1
ATP2B1
ATP2B2
AVPR1A
BCL2
BTG2
BTK
C1QBP
CASR
CBL
CD163
CD5
CD9
CDC42
CDKN2A
CFTR
CHAT
CISH
CORO1B
CREM
CYP3A4
CYTH2
DDX5
DGKD
DGKZ
DLG4
DLX3
DNM1
DVL2
EDF1
EEF1D
EGFR
EIF4E
EIF4EBP1
ELAVL1
ENTPD5
EP300
EWSR1
EZR
F11R
FAS
FBXO25
FLNA
FLNC
FSCN1
GABRB3
GABRG2
GABRR1
GABRR2
GFAP
GFPT1
GJA1
GJB1
GLI3
GMFB
GNA12
GNA15
GNB2L1
GPM6A
GRIA1
GRIA2
GRIA4
GRIN1
GRIN2A
GRIN2B
GRM1
GRM5
GSK3A
GSK3B
HABP4
HAND1
HAND2
HES1
HIST1H1A
HIST1H1B
HIST1H1C
HIST1H1D
HIST1H1E
HIST1H1T
HIST1H3A
HIST3H3
HLA-A
HMGA1
HMGA2
HMGB1
HMGN1
HMGN2
HSP90AA1
HSPA1A
HSPB8
IKBKB
INSR
ITGB1
ITGB2
ITGB4
ITPKA
ITPKB
KCNE1
KCNE4
KCNQ2
KIT
KLF5
KRT18
LCK
LMNA
LMNB1
MARCKS
MBP
MGMT
MTOR
MYLK
MYOD1
NCF1
NFATC1
NFE2L2
NFKBIA
NOS1
NR1H2
NRGN
NUMB
OGG1
OPRD1
PA2G4
PAM
PDLIM7
PEA15
PEBP1
PFKFB1
PFKFB2
PICK1
PLCB1
PLD1
PLD2
POLB
PPARA
PPARG
PPP1R14A
PRKCZ
PRKG1
PSMB4
PTGIR
PTPN11
PTPN12
PTPN6
RAC1
RAF1
RALBP1
RARA
RBCK1
RGS19
RGS2
RGS7
RHO
RHOA
RNF31
RPL10
RRAD
SACM1L
SCRIB
SCTR
SDC2
SDC4
SDPR
SELL
SEMG1
SEMG2
SHC1
SLC1A1
SLC6A9
SNAP23
SNAP25
SPAG1
SPP1
SRC
STXBP1
STXBP3
SYK
TBXA2R
TEP1
TERT
THOC5
TIAM1
TNNI3
TNNT2
TNP1
TNP2
TOP2A
TP53
TRIM29
TRIM41
TRPC3
TRPV6
VCL
VTN
XK
YWHAG
YWHAZ
Entrez ID
2769
5578
HPRD ID
00760
01498
Ensembl ID
ENSG00000060558
ENSG00000154229
Uniprot IDs
P30679
P17252
Q7Z727
PDB IDs
2ELI
3IW4
4DNL
Enriched GO Terms of Interacting Partners
?
G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Signal Transduction
Defense Response
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Cellular Calcium Ion Homeostasis
Calcium Ion Homeostasis
Signaling
Cell Communication
Sensory Perception Of Pain
Cellular Metal Ion Homeostasis
Inflammatory Response
Response To External Stimulus
Opioid Receptor Signaling Pathway
Cellular Cation Homeostasis
Cellular Response To Stimulus
Cellular Ion Homeostasis
Metal Ion Homeostasis
Regulation Of Phosphorus Metabolic Process
Cellular Chemical Homeostasis
Blood Circulation
Regulation Of Adenylate Cyclase Activity
Positive Regulation Of Cytosolic Calcium Ion Concentration
Regulation Of Muscle Contraction
Response To Stress
Chemical Homeostasis
Ion Homeostasis
Synaptic Transmission
Regulation Of Cyclase Activity
Immune Response
Regulation Of Phosphorylation
Cytosolic Calcium Ion Homeostasis
Regulation Of MAPK Cascade
Regulation Of Catalytic Activity
Homeostatic Process
Regulation Of Signaling
Interleukin-8-mediated Signaling Pathway
Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway
Cellular Homeostasis
Negative Regulation Of Muscle Contraction
Negative Regulation Of Adenylate Cyclase Activity
Regulation Of CAMP Biosynthetic Process
Negative Regulation Of Lyase Activity
Response To Stimulus
Regulation Of CAMP Metabolic Process
Regulation Of Sensory Perception Of Pain
Negative Regulation Of Catalytic Activity
Response To Stimulus
Cellular Response To Stimulus
Regulation Of Signaling
Signaling
Cell Communication
Developmental Process
Response To Organic Substance
Positive Regulation Of Metabolic Process
Response To Stress
Multicellular Organismal Development
Response To Wounding
Cell Differentiation
Anatomical Structure Development
Regulation Of Cellular Process
Signal Transduction
Wound Healing
Regulation Of Signal Transduction
Hemostasis
Positive Regulation Of Cellular Metabolic Process
Response To External Stimulus
Blood Coagulation
Regulation Of Body Fluid Levels
System Development
Regulation Of Cellular Component Organization
Cell Surface Receptor Signaling Pathway
Locomotion
Response To Organonitrogen Compound
Regulation Of Intracellular Signal Transduction
Positive Regulation Of Signal Transduction
Cell Development
Regulation Of Catalytic Activity
Positive Regulation Of Transport
Regulation Of Metabolic Process
Response To Abiotic Stimulus
Movement Of Cell Or Subcellular Component
Regulation Of Protein Metabolic Process
Regulation Of Cellular Localization
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of Catalytic Activity
Neurogenesis
Nervous System Development
Organ Development
Generation Of Neurons
Cell-cell Signaling
Intracellular Signal Transduction
Regulation Of Cell Differentiation
Response To Organic Cyclic Compound
Platelet Activation
Regulation Of Cellular Protein Metabolic Process
Tagcloud
?
american
artiodactyla
assigned
block
blot
cattle
chr
conservative
conserved
cow
electrophoresis
erbb2
hybrid
hybridization
localization
localized
means
mink
nf1
pepa
pig
rara
representatives
sheep
southern
swine
synteny
tk1
umph2
Tagcloud (Difference)
?
american
artiodactyla
assigned
block
blot
cattle
chr
conservative
conserved
cow
electrophoresis
erbb2
hybrid
hybridization
localization
localized
means
mink
nf1
pepa
pig
rara
representatives
sheep
southern
swine
synteny
tk1
umph2
Tagcloud (Intersection)
?