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NUDT18 and NT5C2
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
NUDT18
NT5C2
Gene Name
nudix (nucleoside diphosphate linked moiety X)-type motif 18
5-nucleotidase, cytosolic II
Image
Gene Ontology Annotations
Cellular Component
Cytosol
Cytosol
Molecular Function
Magnesium Ion Binding
Protein Binding
8-oxo-dGDP Phosphatase Activity
8-oxo-GDP Phosphatase Activity
8-hydroxy-dADP Phosphatase Activity
Nucleotide Binding
Protein Binding
5'-nucleotidase Activity
Metal Ion Binding
Nucleoside Phosphotransferase Activity
Biological Process
Nucleobase-containing Small Molecule Catabolic Process
Small Molecule Metabolic Process
DADP Catabolic Process
DGDP Catabolic Process
GDP Catabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Purine Nucleobase Metabolic Process
Purine Nucleotide Catabolic Process
Phosphorylation
Dephosphorylation
Drug Metabolic Process
Small Molecule Metabolic Process
IMP Metabolic Process
Adenosine Metabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Pathways
Purine catabolism
Purine metabolism
Metabolism of nucleotides
Abacavir transport and metabolism
Abacavir metabolism
Drugs
Adenosine triphosphate
Ribavirin
Diseases
GWAS
Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) (
23453885
)
Blood pressure (
21572416
21909110
)
Coronary heart disease (
21378990
)
Schizophrenia (
21926974
22688191
23894747
)
Systolic blood pressure (
19430483
21909115
)
Protein-Protein Interactions
34 interactors:
APIP
COIL
CUTC
DCTD
DHPS
DUT
EVI5L
GLUL
GNMT
GSE1
HSD17B14
KCTD13
KCTD17
KHDRBS3
KRT15
KRTAP4-12
KXD1
NADK
NAT9
NT5C2
PAICS
PCBD1
PSME3
RAB3IL1
RABAC1
RAD54B
RWDD1
SDPR
TARBP2
TERF2IP
TIFA
TRAF2
TRIM37
ZBED1
10 interactors:
ATP5O
CALM1
FXR2
MOB1B
MOB3B
MOB3C
NME7
NOC4L
NUDT18
SDCBP
Entrez ID
79873
22978
HPRD ID
07992
02686
Ensembl ID
ENSG00000076685
Uniprot IDs
Q6ZVK8
A8K6K2
B7Z382
P49902
PDB IDs
3GG6
2J2C
2JC9
2JCM
2XCV
2XCW
2XCX
2XJB
2XJC
2XJD
2XJE
2XJF
4H4B
Enriched GO Terms of Interacting Partners
?
Protein Homooligomerization
Protein Oligomerization
Nucleoside Metabolic Process
Protein Tetramerization
Nucleobase-containing Small Molecule Metabolic Process
Protein Complex Assembly
Cellular Nitrogen Compound Metabolic Process
Cellular Component Assembly
Protein Homotetramerization
Nitrogen Compound Metabolic Process
Catabolic Process
Small Molecule Metabolic Process
S-adenosylmethionine Metabolic Process
Purine Nucleoside Metabolic Process
Methionine Metabolic Process
Regulation Of Protein Homodimerization Activity
IMP Metabolic Process
Alpha-amino Acid Metabolic Process
Nucleotide Biosynthetic Process
Positive Regulation Of NF-kappaB Transcription Factor Activity
Nucleotide Metabolic Process
Polyamine Metabolic Process
Cofactor Metabolic Process
Nucleobase-containing Compound Metabolic Process
Pyrimidine Nucleobase Metabolic Process
Protein Autoubiquitination
Purine Nucleobase Metabolic Process
Sulfur Amino Acid Metabolic Process
DUMP Biosynthetic Process
Deoxyhypusine Biosynthetic Process From Spermidine
DUTP Catabolic Process
Negative Regulation Of DNA Recombination At Telomere
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Pyrimidine Nucleoside Biosynthetic Process
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Cellular Amino Acid Metabolic Process
I-kappaB Kinase/NF-kappaB Signaling
Glutamine Biosynthetic Process
MiRNA Loading Onto RISC Involved In Gene Silencing By MiRNA
Spermidine Catabolic Process
L-methionine Biosynthetic Process From S-adenosylmethionine
Cellular Modified Amino Acid Metabolic Process
Pyrimidine Nucleotide Metabolic Process
Pyrimidine Nucleoside Metabolic Process
Targeting Of MRNA For Destruction Involved In RNA Interference
DUMP Metabolic Process
NADP Biosynthetic Process
DUTP Metabolic Process
Negative Regulation Of Cilium Assembly
Purine Nucleoside Metabolic Process
Ribonucleotide Metabolic Process
Nucleoside Metabolic Process
Purine Nucleotide Metabolic Process
Ribose Phosphate Metabolic Process
Nucleoside Diphosphate Metabolic Process
Organophosphate Metabolic Process
Nucleoside Triphosphate Biosynthetic Process
GDP Catabolic Process
DGDP Catabolic Process
DADP Catabolic Process
Nucleotide Metabolic Process
Nucleobase-containing Small Molecule Metabolic Process
Phosphate-containing Compound Metabolic Process
Positive Regulation Of Extracellular Vesicular Exosome Assembly
Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity
Purine Nucleotide Biosynthetic Process
Ribose Phosphate Biosynthetic Process
Regulation Of High Voltage-gated Calcium Channel Activity
Ciliary Receptor Clustering Involved In Smoothened Signaling Pathway
Regulation Of Extracellular Vesicular Exosome Assembly
Purine Ribonucleoside Diphosphate Catabolic Process
Nucleobase-containing Small Molecule Catabolic Process
Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Membrane Organization
Positive Regulation Of Phosphorylation
Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Ribonucleoside Diphosphate Catabolic Process
Establishment Of Localization In Cell
Nucleoside Diphosphate Catabolic Process
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Positive Regulation Of Exosomal Secretion
Regulation Of Exosomal Secretion
Deoxyribonucleoside Diphosphate Metabolic Process
Detection Of Calcium Ion
Substrate-dependent Cell Migration, Cell Extension
Energy Derivation By Oxidation Of Organic Compounds
Nucleotide Biosynthetic Process
Purine Ribonucleoside Catabolic Process
Regulation Of Cell Communication By Electrical Coupling
Positive Regulation Of Phosphoprotein Phosphatase Activity
Small Molecule Metabolic Process
Cellular Localization
Positive Regulation Of Peptidyl-threonine Phosphorylation
Positive Regulation Of Protein Autophosphorylation
Mitochondrial ATP Synthesis Coupled Proton Transport
Positive Regulation Of Nitric-oxide Synthase Activity
Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion
Glycogen Catabolic Process
Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Tagcloud
?
atp2b1
atxn2
bdkrb2
cacnb2
csk
cyp171a
cyp17a1
cyp1a2
eh
gwas
hfe
jan
meant
mthfr
nppa
nppb
overlapped
pharmacogenomics
plcd3
plekha7
sh2b3
stk39
tbx3
tbx5
ulk3
ulk4
umod
wnk4
znf652
Tagcloud (Difference)
?
atp2b1
atxn2
bdkrb2
cacnb2
csk
cyp171a
cyp17a1
cyp1a2
eh
gwas
hfe
jan
meant
mthfr
nppa
nppb
overlapped
pharmacogenomics
plcd3
plekha7
sh2b3
stk39
tbx3
tbx5
ulk3
ulk4
umod
wnk4
znf652
Tagcloud (Intersection)
?