GJB1 and CLEC7A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GJB1	CLEC7A
Description		gap junction protein beta 1	C-type lectin domain containing 7A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction	Cytoplasm Plasma Membrane Cell Surface Membrane
	Molecular Function	Gap Junction Channel Activity Protein Binding Identical Protein Binding	(1->3)-beta-D-glucan Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity MHC Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Cell Communication Cell-cell Signaling Nervous System Development Gap Junction Assembly Transmembrane Transport	Cell Activation Response To Yeast Detection Of Yeast Stimulatory C-type Lectin Receptor Signaling Pathway Immune System Process Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Cell Surface Pattern Recognition Receptor Signaling Pathway Phagocytosis, Recognition Inflammatory Response Cell Recognition Positive Regulation Of Cell Population Proliferation Carbohydrate Mediated Signaling Positive Regulation Of Gene Expression Detection Of Fungus Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Detection Of Molecule Of Fungal Origin Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Superoxide Anion Generation T Cell Activation Defense Response To Protozoan Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Innate Immune Response Leukocyte Activation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Phagocytosis Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Lymphocyte Activation Positive Regulation Of Respiratory Burst Antifungal Innate Immune Response Regulation Of Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Wound Healing Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Maturation Positive Regulation Of T-helper 17 Type Immune Response
Pathways		Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly	CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy	Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS
Interacting Genes		57 interacting genes: APOL3 APP BMP10 C1GALT1 C2CD2L C3orf52 CALM1 CD37 CD79A CDIPT CLEC7A CMTM3 CMTM5 CNST COMT CTXN3 CXCL9 EFNA5 EGFR EMP3 EPHA1 GJB2 GLP1R GPR25 IER3IP1 ITGAM LAT LHFPL2 MAL MAL2 MFF MS4A13 MST1R NDUFB11 NIPAL4 PRKACA PRKCA PTPN2 PTPN9 RTP2 SCD SERTM1 SLC12A7 SRC STX8 TEX264 TF TM4SF4 TMEM120B TMEM14C TMEM19 TMEM218 TMEM98 UPK1B VEGFA VKORC1 YIPF6	48 interacting genes: ADAM33 AIP ARL13B ASGR2 BNIP3 BNIP3L C14orf180 CALM3 CD53 CD74 CFTR CTXN3 CXCL9 FAM3A FCGR1A FNDC9 GJB1 HSPD1 IFNGR2 IL1RL1 JAGN1 KLRC1 KTN1 MTIF3 NEMP1 NINJ2 NSG2 OCLN OLFM4 OPRM1 PTTG1IP RANBP9 RHOU SAR1A SEC22A SGCB SMIM3 SPINT1 SUSD3 SYNE4 TEX29 TLCD4 TMEM79 TMPRSS2 TMPRSS4 UPK2 VSIR ZFPL1
Entrez ID		2705	64581
HPRD ID		02367	08396
Ensembl ID		ENSG00000169562	ENSG00000172243
Uniprot IDs		P08034	A0A0S2Z5Q1 A0A2Z5YRT6 A0A2Z5YRU4 Q68D78 Q9BXN2
PDB IDs		5KK9 7ZXM 7ZXN 7ZXO 7ZXP 7ZXQ 7ZXT 8QJF 8QJH 8QK6 8QKI
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Membrane Raft Regulation Of Protein Localization Positive Regulation Of Protein Localization Intestinal Epithelial Cell Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Columnar/cuboidal Epithelial Cell Development Protein Binding Endoplasmic Reticulum Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Superoxide Anion Generation Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Vesicle-mediated Transport Positive Regulation Of Transport Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Establishment Of Protein Localization Leukocyte Activation Regulation Of Phosphorus Metabolic Process Ephrin Receptor Binding Connexin Binding Regulation Of Superoxide Metabolic Process Positive Regulation Of Protein Phosphorylation Integrin Binding Positive Regulation Of MAPK Cascade Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Transport Regulation Of Blood Circulation Positive Regulation Of Endocytosis Positive Regulation Of Phosphorylation Plasma Membrane Raft Membrane Raft Distribution Regulation Of Cell Junction Assembly Cell Surface Regulation Of Calcium-mediated Signaling Cell Activation Regulation Of MAPK Cascade Signaling Receptor Activator Activity Regulation Of Protein Phosphorylation Membrane Raft Localization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of ERK1 And ERK2 Cascade	Membrane Plasma Membrane Positive Regulation Of Viral Entry Into Host Cell Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Life Cycle Protein Binding Mitochondrial Outer Membrane Permeabilization Mitochondrial Protein Catabolic Process Cytokine Receptor Activity External Side Of Plasma Membrane
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