GJB1 and C2CD2L

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GJB1	C2CD2L
Description		gap junction protein beta 1	C2CD2 like
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cortical Endoplasmic Reticulum Cytoplasmic Side Of Apical Plasma Membrane Endoplasmic Reticulum-plasma Membrane Contact Site
	Molecular Function	Gap Junction Channel Activity Protein Binding Identical Protein Binding	Protein Binding Lipid Binding Phosphatidylinositol Transfer Activity Phosphatidylinositol Binding Insulin Binding
	Biological Process	Cell Communication Cell-cell Signaling Nervous System Development Gap Junction Assembly Transmembrane Transport	Lipid Transport Phospholipid Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intermembrane Lipid Transfer
Pathways		Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Glycated hemoglobin levels ( 34059833) Heel bone mineral density ( 30598549)
Interacting Genes		57 interacting genes: APOL3 APP BMP10 C1GALT1 C2CD2L C3orf52 CALM1 CD37 CD79A CDIPT CLEC7A CMTM3 CMTM5 CNST COMT CTXN3 CXCL9 EFNA5 EGFR EMP3 EPHA1 GJB2 GLP1R GPR25 IER3IP1 ITGAM LAT LHFPL2 MAL MAL2 MFF MS4A13 MST1R NDUFB11 NIPAL4 PRKACA PRKCA PTPN2 PTPN9 RTP2 SCD SERTM1 SLC12A7 SRC STX8 TEX264 TF TM4SF4 TMEM120B TMEM14C TMEM19 TMEM218 TMEM98 UPK1B VEGFA VKORC1 YIPF6	31 interacting genes: AQP6 ARL13B CD79A CHODL CISD2 CLRN1 CPEB2 CXCR3 EBP EPB41 FCER1G GJA8 GJB1 HIBADH IL3RA MUC1 OPRM1 PDZK1IP1 REEP2 REEP4 SDCBP SLC10A6 SLC18A1 SLC61A1 TMEM14B TMEM179B TMEM31 TMEM86B TMEM9 TMPRSS2 TMX2
Entrez ID		2705	9854
HPRD ID		02367	15533
Ensembl ID		ENSG00000169562	ENSG00000172375
Uniprot IDs		P08034	O14523
PDB IDs		5KK9 7ZXM 7ZXN 7ZXO 7ZXP 7ZXQ 7ZXT 8QJF 8QJH 8QK6 8QKI	5TOD
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Membrane Raft Regulation Of Protein Localization Positive Regulation Of Protein Localization Intestinal Epithelial Cell Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Columnar/cuboidal Epithelial Cell Development Protein Binding Endoplasmic Reticulum Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Superoxide Anion Generation Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Vesicle-mediated Transport Positive Regulation Of Transport Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Establishment Of Protein Localization Leukocyte Activation Regulation Of Phosphorus Metabolic Process Ephrin Receptor Binding Connexin Binding Regulation Of Superoxide Metabolic Process Positive Regulation Of Protein Phosphorylation Integrin Binding Positive Regulation Of MAPK Cascade Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Transport Regulation Of Blood Circulation Positive Regulation Of Endocytosis Positive Regulation Of Phosphorylation Plasma Membrane Raft Membrane Raft Distribution Regulation Of Cell Junction Assembly Cell Surface Regulation Of Calcium-mediated Signaling Cell Activation Regulation Of MAPK Cascade Signaling Receptor Activator Activity Regulation Of Protein Phosphorylation Membrane Raft Localization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of ERK1 And ERK2 Cascade	Membrane Endoplasmic Reticulum Membrane Interleukin-3-mediated Signaling Pathway
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