GJB1 and TM4SF4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GJB1	TM4SF4
Description		gap junction protein beta 1	transmembrane 4 L six family member 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction	Membrane
	Molecular Function	Gap Junction Channel Activity Protein Binding Identical Protein Binding	Protein Binding
	Biological Process	Cell Communication Cell-cell Signaling Nervous System Development Gap Junction Assembly Transmembrane Transport	Tissue Regeneration
Pathways		Oligomerization of connexins into connexons Oligomerization of connexins into connexons Transport of connexins along the secretory pathway Gap junction assembly
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS			Alanine aminotransferase levels ( 33339817 33547301) Alanine transaminase levels ( 29403010) Gallstone disease ( 27094239 30504769) Gamma glutamyl transferase levels ( 29403010 33339817) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels ( 30993211) Thyroid stimulating hormone levels ( 30367059 32769997) Urate levels ( 31578528)
Interacting Genes		57 interacting genes: APOL3 APP BMP10 C1GALT1 C2CD2L C3orf52 CALM1 CD37 CD79A CDIPT CLEC7A CMTM3 CMTM5 CNST COMT CTXN3 CXCL9 EFNA5 EGFR EMP3 EPHA1 GJB2 GLP1R GPR25 IER3IP1 ITGAM LAT LHFPL2 MAL MAL2 MFF MS4A13 MST1R NDUFB11 NIPAL4 PRKACA PRKCA PTPN2 PTPN9 RTP2 SCD SERTM1 SLC12A7 SRC STX8 TEX264 TF TM4SF4 TMEM120B TMEM14C TMEM19 TMEM218 TMEM98 UPK1B VEGFA VKORC1 YIPF6	22 interacting genes: APH1B CD79A CLEC17A CMTM2 CREB3 ERGIC3 FATE1 FFAR2 GJB1 GJB4 GJB5 GLP1R GPR101 GPR37L1 GPR42 GPX8 KCNK5 LHFPL5 OPRM1 SLC10A6 TBXA2R TMEM14B
Entrez ID		2705	7104
HPRD ID		02367	07585
Ensembl ID		ENSG00000169562	ENSG00000169903
Uniprot IDs		P08034	P48230
PDB IDs		5KK9 7ZXM 7ZXN 7ZXO 7ZXP 7ZXQ 7ZXT 8QJF 8QJH 8QK6 8QKI
Enriched GO Terms of Interacting Partners?		Membrane Plasma Membrane Membrane Raft Regulation Of Protein Localization Positive Regulation Of Protein Localization Intestinal Epithelial Cell Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cell Surface Receptor Signaling Pathway Columnar/cuboidal Epithelial Cell Development Protein Binding Endoplasmic Reticulum Regulation Of Superoxide Anion Generation Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Signal Transduction Positive Regulation Of Superoxide Anion Generation Regulation Of Cellular Localization Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Signal Transduction Regulation Of Vesicle-mediated Transport Positive Regulation Of Transport Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Establishment Of Protein Localization Leukocyte Activation Regulation Of Phosphorus Metabolic Process Ephrin Receptor Binding Connexin Binding Regulation Of Superoxide Metabolic Process Positive Regulation Of Protein Phosphorylation Integrin Binding Positive Regulation Of MAPK Cascade Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Transport Regulation Of Blood Circulation Positive Regulation Of Endocytosis Positive Regulation Of Phosphorylation Plasma Membrane Raft Membrane Raft Distribution Regulation Of Cell Junction Assembly Cell Surface Regulation Of Calcium-mediated Signaling Cell Activation Regulation Of MAPK Cascade Signaling Receptor Activator Activity Regulation Of Protein Phosphorylation Membrane Raft Localization Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of ERK1 And ERK2 Cascade	Membrane G Protein-coupled Receptor Activity Connexin Complex Gap Junction Channel Activity Gap Junction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Peptide Receptor Activity G Protein-coupled Receptor Signaling Pathway Plasma Membrane Transmembrane Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Blood Pressure Glucagon-like Peptide 1 Receptor Activity Positive Regulation Of Blood Pressure Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Positive Regulation Of Deacetylase Activity Sodium-dependent Organic Anion Transmembrane Transporter Activity Sodium-dependent Organic Anion Transport Negative Regulation Of Blood Pressure
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