NT5C3A and GNAQ

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NT5C3A	GNAQ
Description		5'-nucleotidase, cytosolic IIIA	G protein subunit alpha q
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Nuclear Body	Photoreceptor Outer Segment Nucleus Cytoplasm Lysosomal Membrane Golgi Apparatus Heterotrimeric G-protein Complex Plasma Membrane Membrane Nuclear Membrane Extracellular Exosome Postsynaptic Cytosol
	Molecular Function	Nucleotide Binding TRNA 2'-phosphotransferase Activity Magnesium Ion Binding Protein Binding 5'-nucleotidase Activity Transferase Activity Hydrolase Activity Metal Ion Binding	Nucleotide Binding G Protein-coupled Receptor Binding GTPase Activity G Protein Activity GTPase Activator Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding Enzyme Regulator Activity G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Pyrimidine Nucleoside Metabolic Process Nucleotide Metabolic Process Defense Response To Virus	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Glutamate Receptor Signaling Pathway Neuropeptide Signaling Pathway Blood Coagulation Phototransduction, Visible Light Entrainment Of Circadian Clock Hormone-mediated Signaling Pathway Regulation Of Platelet Activation Response To Prostaglandin E Protein Stabilization Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Acidic PH Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway
Pathways			PLC beta mediated events PLC beta mediated events G-protein activation Acetylcholine regulates insulin secretion Acetylcholine regulates insulin secretion G alpha (q) signalling events G alpha (q) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 Thromboxane signalling through TP receptor Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion Thrombin signalling through proteinase activated receptors (PARs) Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
Drugs
Diseases		Anemia due to disorders of nucleotide metabolism, including: Adenylate kinase (AK) deficiency; Uridine 5-prime monophosphate hydrolase (UMPH1) deficiency
GWAS		Estimated glomerular filtration rate ( 31152163) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 32888494) Serum metabolite levels ( 33031748)	Bipolar disorder ( 31043756) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		6 interacting genes: DESI1 GNAQ NDUFAB1 UBQLN1 UBQLN2 VANGL1	48 interacting genes: ADHFE1 ADRA1B AIP AKAP13 BDKRB1 BTK CCR5 CHRM3 CRHR1 CYTH1 CYTH2 FFAR1 FFAR2 GALR2 GRK2 GRM2 GRM4 GRM7 HTR2A HTR2B HTR2C HTR6 KDR LUM MRGPRX1 NHERF1 NT5C3A PIK3CA PLCB1 PLCB2 PPT1 PTGIR RGS13 RGS16 RGS18 RGS2 RGS4 RGS5 RGS7 RIC8A RIC8B S1PR2 S1PR3 TBXA2R TSHR TTC1 TUB VIPR1
Entrez ID		51251	2776
HPRD ID		05871	02998
Ensembl ID		ENSG00000122643	ENSG00000156052
Uniprot IDs		A0A090N7U2 Q9H0P0 X6RM59	A0A024R240 P50148
PDB IDs		2CN1 2JGA 2VKQ	6VU5 7EZM 7F6G 7F6H 7F6I 7F8W 7W3Z 7W40 7XOW 8G59 8IA7 8IYS 8J9N 8JPB 8JPC 8JPE 8SZG 8UQN 8UQO 8XGO 8XGS 8Y52 8ZJD 8ZJE 9K27
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Acyl Carrier Activity Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Acyl Binding Autophagosome Organization Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Mitochondrial Large Ribosomal Subunit Binding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Mitochondrial [2Fe-2S] Assembly Complex Protein Lipoylation Negative Regulation Of Clathrin-dependent Endocytosis Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Vacuole Organization Protein Metabolic Process Regulation Of Macroautophagy DeSUMOylase Activity Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Phospholipase C-activating Serotonin Receptor Signaling Pathway [2Fe-2S] Cluster Assembly Mannosyltransferase Activity Importin-alpha Family Protein Binding Palmitoyl-(protein) Hydrolase Activity Protein Desumoylation Response To Endoplasmic Reticulum Stress Mucociliary Clearance Iron-sulfur Cluster Assembly Complex Macromolecule Depalmitoylation Regulation Of Toll-like Receptor 3 Signaling Pathway Phototransduction, Visible Light Long-chain Fatty Acyl-CoA Hydrolase Activity Aggrephagy Autophagy G Protein-coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Receptor Internalization Guanyl Nucleotide Binding Regulation Of Clathrin-dependent Endocytosis	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Activity Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger G-protein Alpha-subunit Binding Regulation Of Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality System Process Serotonin Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Positive Regulation Of Phosphatidylinositol Biosynthetic Process Gq/11-coupled Serotonin Receptor Activity Serotonin Receptor Activity Membrane G Protein-coupled Serotonin Receptor Activity Cell-cell Signaling Regulation Of Amine Transport Regulation Of Sequestering Of Calcium Ion G Protein-coupled Serotonin Receptor Complex Signaling Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neurotransmitter Receptor Activity Cell Communication Calcium Ion Transmembrane Import Into Cytosol Regulation Of System Process G Protein-coupled Serotonin Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Muscle System Process GTPase Activator Activity Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Transport Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Secretion Phospholipase C-activating Serotonin Receptor Signaling Pathway Muscle Contraction Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Serotonin Binding Guanyl-nucleotide Exchange Factor Activity Regulation Of Secretion By Cell
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