NT5C3A and VANGL1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NT5C3A	VANGL1
Description		5'-nucleotidase, cytosolic IIIA	VANGL planar cell polarity protein 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Nuclear Body	Extracellular Region Plasma Membrane Membrane Lateral Plasma Membrane
	Molecular Function	Nucleotide Binding TRNA 2'-phosphotransferase Activity Magnesium Ion Binding Protein Binding 5'-nucleotidase Activity Transferase Activity Hydrolase Activity Metal Ion Binding	Protein Binding
	Biological Process	Pyrimidine Nucleoside Metabolic Process Nucleotide Metabolic Process Defense Response To Virus	Pigmentation Wnt Signaling Pathway, Planar Cell Polarity Pathway Mucociliary Clearance
Pathways			RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs
Diseases		Anemia due to disorders of nucleotide metabolism, including: Adenylate kinase (AK) deficiency; Uridine 5-prime monophosphate hydrolase (UMPH1) deficiency	Spina bifida Caudal regression syndrome and Sirenomelia
GWAS		Estimated glomerular filtration rate ( 31152163) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 32888494) Serum metabolite levels ( 33031748)	Coronary artery disease ( 33020668) Gut microbiota (bacterial taxa) ( 27694959) Iron status biomarkers (ferritin levels) ( 33536631) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Optic disc size ( 31809533)
Interacting Genes		6 interacting genes: DESI1 GNAQ NDUFAB1 UBQLN1 UBQLN2 VANGL1	12 interacting genes: CD82 DVL1 DVL2 DVL3 GMFG LINC00839 NT5C3A RAPGEF5 SMYD3 SRPK1 THAP2 UBC
Entrez ID		51251	81839
HPRD ID		05871	18279
Ensembl ID		ENSG00000122643	ENSG00000173218
Uniprot IDs		A0A090N7U2 Q9H0P0 X6RM59	Q8TAA9
PDB IDs		2CN1 2JGA 2VKQ	8ZXD 9JK6 9JK8 9JK9
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Acyl Carrier Activity Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Acyl Binding Autophagosome Organization Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Mitochondrial Large Ribosomal Subunit Binding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Mitochondrial [2Fe-2S] Assembly Complex Protein Lipoylation Negative Regulation Of Clathrin-dependent Endocytosis Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Vacuole Organization Protein Metabolic Process Regulation Of Macroautophagy DeSUMOylase Activity Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Phospholipase C-activating Serotonin Receptor Signaling Pathway [2Fe-2S] Cluster Assembly Mannosyltransferase Activity Importin-alpha Family Protein Binding Palmitoyl-(protein) Hydrolase Activity Protein Desumoylation Response To Endoplasmic Reticulum Stress Mucociliary Clearance Iron-sulfur Cluster Assembly Complex Macromolecule Depalmitoylation Regulation Of Toll-like Receptor 3 Signaling Pathway Phototransduction, Visible Light Long-chain Fatty Acyl-CoA Hydrolase Activity Aggrephagy Autophagy G Protein-coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Receptor Internalization Guanyl Nucleotide Binding Regulation Of Clathrin-dependent Endocytosis	Positive Regulation Of Neuron Projection Arborization Regulation Of Neuron Projection Arborization Convergent Extension Involved In Neural Plate Elongation Wnt Signaling Pathway, Planar Cell Polarity Pathway Frizzled Binding Convergent Extension Involved In Organogenesis Non-canonical Wnt Signaling Pathway Convergent Extension Involved In Gastrulation Regulation Of Cell Morphogenesis Convergent Extension Canonical Wnt Signaling Pathway Positive Regulation Of Cell Projection Organization Cochlea Morphogenesis Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Localization To Presynapse Wnt Signaling Pathway Small GTPase Binding Clathrin-coated Vesicle Outflow Tract Morphogenesis Lateral Plasma Membrane Heart Looping Embryonic Heart Tube Morphogenesis Regulation Of Cell Projection Organization Actin Filament Debranching TRNA 2'-phosphotransferase Activity Regulation Of Actin Cytoskeleton Organization Protein Phosphorylation Beta-catenin Binding Nuclear Body Regulation Of Actin Filament-based Process Positive Regulation Of JNK Cascade Phosphorylation Epithelial Tube Morphogenesis Regulation Of Anatomical Structure Morphogenesis Cytoplasmic Vesicle Histone H3K36 Dimethyltransferase Activity
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