NT5C3A and NDUFAB1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NT5C3A	NDUFAB1
Description		5'-nucleotidase, cytosolic IIIA	NADH:ubiquinone oxidoreductase subunit AB1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Nuclear Body	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Mitochondrial Membrane Respiratory Chain Complex I Mitochondrial [2Fe-2S] Assembly Complex Iron-sulfur Cluster Assembly Complex
	Molecular Function	Nucleotide Binding TRNA 2'-phosphotransferase Activity Magnesium Ion Binding Protein Binding 5'-nucleotidase Activity Transferase Activity Hydrolase Activity Metal Ion Binding	Acyl Binding Acyl Carrier Activity Structural Molecule Activity Fatty Acid Binding Calcium Ion Binding Protein Binding Mitochondrial Large Ribosomal Subunit Binding
	Biological Process	Pyrimidine Nucleoside Metabolic Process Nucleotide Metabolic Process Defense Response To Virus	Mitochondrial Electron Transport, NADH To Ubiquinone Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Aerobic Respiration Protein Lipoylation Iron-sulfur Cluster Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis [2Fe-2S] Cluster Assembly
Pathways			Respiratory electron transport Complex I biogenesis Mitochondrial Fatty Acid Beta-Oxidation Protein lipoylation Mitochondrial ribosome-associated quality control
Drugs			NADH
Diseases		Anemia due to disorders of nucleotide metabolism, including: Adenylate kinase (AK) deficiency; Uridine 5-prime monophosphate hydrolase (UMPH1) deficiency
GWAS		Estimated glomerular filtration rate ( 31152163) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 27863252 32888494) Serum metabolite levels ( 33031748)	Bipolar disorder ( 17554300)
Interacting Genes		6 interacting genes: DESI1 GNAQ NDUFAB1 UBQLN1 UBQLN2 VANGL1	35 interacting genes: ACTN3 BBC3 BEX5 CCDC24 CNTF EIF3B ERBB3 FEM1A FHL3 FNDC3B HINFP KCTD9 LMO2 LNX1 MBLAC1 MORN3 MRPL23 NOXA1 NRF1 NT5C3A NTAQ1 OIP5 POP5 PPP1R16A PSMC3 RBM18 SLIRP SMYD3 THAP1 TLX3 TOX2 VAC14 ZNF19 ZNF410 ZNF829
Entrez ID		51251	4706
HPRD ID		05871	11951
Ensembl ID		ENSG00000122643	ENSG00000004779
Uniprot IDs		A0A090N7U2 Q9H0P0 X6RM59	O14561
PDB IDs		2CN1 2JGA 2VKQ	2DNW 5OOL 5OOM 5XTB 5XTC 5XTD 5XTH 5XTI 6ODD 7A5H 7A5J 7O9K 7O9M 7ODR 7ODS 7ODT 7OF0 7OF2 7OF3 7OF5 7OF7 7OI6 7OI7 7OI8 7OI9 7OIC 7OID 7OIE 7PD3 7PO4 7QH6 7QH7 8K2B 8PK0 8QSJ 8QU5
Enriched GO Terms of Interacting Partners?		Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Acyl Carrier Activity Regulation Of Proteolysis Regulation Of Protein Catabolic Process Negative Regulation Of Store-operated Calcium Channel Activity Autophagosome Regulation Of Response To Endoplasmic Reticulum Stress Autophagosome Assembly ERAD Pathway Acyl Binding Autophagosome Organization Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteasomal Protein Catabolic Process Mitochondrial Large Ribosomal Subunit Binding Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Mitochondrial [2Fe-2S] Assembly Complex Protein Lipoylation Negative Regulation Of Clathrin-dependent Endocytosis Adenylate Cyclase-activating G Protein-coupled CAMP Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway Vacuole Organization Protein Metabolic Process Regulation Of Macroautophagy DeSUMOylase Activity Positive Regulation Of Proteolysis Positive Regulation Of Protein Catabolic Process Phospholipase C-activating Serotonin Receptor Signaling Pathway [2Fe-2S] Cluster Assembly Mannosyltransferase Activity Importin-alpha Family Protein Binding Palmitoyl-(protein) Hydrolase Activity Protein Desumoylation Response To Endoplasmic Reticulum Stress Mucociliary Clearance Iron-sulfur Cluster Assembly Complex Macromolecule Depalmitoylation Regulation Of Toll-like Receptor 3 Signaling Pathway Phototransduction, Visible Light Long-chain Fatty Acyl-CoA Hydrolase Activity Aggrephagy Autophagy G Protein-coupled Glutamate Receptor Signaling Pathway Negative Regulation Of Receptor Internalization Guanyl Nucleotide Binding Regulation Of Clathrin-dependent Endocytosis
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