XBP1 and CREBZF

Number of citations of the paper that reports this interaction (PubMedID 23661758)
48

Data Source:
BioGRID (fluorescent resonance energy transfer)

		XBP1	CREBZF
Description		X-box binding protein 1	CREB/ATF bZIP transcription factor
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Mitochondrion RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Protease Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Nuclear Estrogen Receptor Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Ubiquitin-like Protein Ligase Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Cell Growth Liver Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Glandular Epithelial Cell Maturation Positive Regulation Of Immunoglobulin Production Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Lipid Metabolic Process Fatty Acid Biosynthetic Process Autophagy Apoptotic Process Immune Response Response To Unfolded Protein Muscle Organ Development Positive Regulation Of Cell Population Proliferation Regulation Of Autophagy Positive Regulation Of Autophagy Negative Regulation Of Myotube Differentiation Protein Transport Cell Differentiation Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Exocrine Pancreas Development Regulation Of Protein Stability Protein Destabilization Cellular Response To Nutrient Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-6 Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Intracellular Triglyceride Homeostasis Positive Regulation Of Vascular Wound Healing Cellular Response To Vascular Endothelial Growth Factor Stimulus IRE1-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response ERAD Pathway Cellular Response To Glucose Starvation Positive Regulation Of Protein Import Into Nucleus Cholesterol Homeostasis Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of SMAD Protein Signal Transduction Adipose Tissue Development Epithelial Cell Maturation Involved In Salivary Gland Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phospholipid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-4 Cellular Response To Peptide Hormone Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Plasma Cell Differentiation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Acetylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lactation Positive Regulation Of ERAD Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Virus ATF6-mediated Unfolded Protein Response Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-binding Transcription Factor Activity Integrated Stress Response Signaling
Pathways
Drugs
Diseases
GWAS		Esophageal cancer (squamous cell) ( 22960999) Esophageal squamous cell carcinoma ( 25129146) Heel bone mineral density ( 28869591) Mean arterial pressure ( 29403010) Pancreatic cancer ( 25086665) Serum alkaline phosphatase levels ( 33547301)	Refractive error ( 32231278)
Interacting Genes		22 interacting genes: ATF6 ATF6B CREBZF ESR1 FOS FUBP3 GLI1 H1-0 H1-10 HDGF MDM2 MTNR1B NR0B2 PCBD2 RBL2 SRSF1 SSX4 TRIP4 UBE2I UBE2V1 ZNF440 ZNF580	19 interacting genes: ACYP2 ATF4 ATF6B BTG3 CTNNBL1 DSCR9 HCFC1 HEY1 LCOR NFE2L1 NFE2L2 NRIP1 RALBP1 RSPH1 TIAM1 TP53 TTC23 XBP1 ZNF512B
Entrez ID		7494	58487
HPRD ID		01908	07340
Ensembl ID		ENSG00000100219	ENSG00000137504
Uniprot IDs		B1AHH1 P17861	E9PIM0 Q9NS37
PDB IDs		6R5Q 6R6G 6R6P 6R7Q
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process ATF6-mediated Unfolded Protein Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Chromatin Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II ER-nucleus Signaling Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coregulator Binding RNA Polymerase II Transcription Regulator Complex Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Animal Organ Regeneration Negative Regulation Of Nucleobase-containing Compound Metabolic Process Peroxisome Proliferator Activated Receptor Binding Transcription Repressor Complex Endoplasmic Reticulum Unfolded Protein Response RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Estrogen Stimulus SUMO Transferase Activity Transcription Cis-regulatory Region Binding Cellular Response To Reactive Oxygen Species Estrogen Receptor Signaling Pathway Response To Immobilization Stress Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Liver Regeneration Regeneration Sequence-specific Double-stranded DNA Binding Regulation Of Endoplasmic Reticulum Unfolded Protein Response Nuclear Estrogen Receptor Binding	ER-nucleus Signaling Pathway Cellular Response To Glucose Starvation Response To Endoplasmic Reticulum Stress Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Response To Endoplasmic Reticulum Stress DNA-binding Transcription Factor Activity Negative Regulation Of RNA Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Transcription Cis-regulatory Region Binding Nuclear Estrogen Receptor Binding Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Histone Deacetylase Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleoplasm ATF6-mediated Unfolded Protein Response Response To Oxidative Stress Cellular Response To Starvation Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process PERK-mediated Unfolded Protein Response Promoter-specific Chromatin Binding Cellular Response To Oxidative Stress General Transcription Initiation Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Starvation Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Nutrient Levels DNA Binding Positive Regulation Of ERAD Pathway Cellular Response To Laminar Fluid Shear Stress DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Cellular Response To Chemical Stress Negative Regulation Of Macromolecule Biosynthetic Process Intracellular Signaling Cassette Nucleus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
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