XBP1 and TRIP4

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		XBP1	TRIP4
Description		X-box binding protein 1	thyroid hormone receptor interactor 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane RNA Polymerase II Transcription Regulator Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cytoskeleton Nuclear Body Neuromuscular Junction Protein-containing Complex RQC-trigger Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Protease Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Kinase Binding Nuclear Estrogen Receptor Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Histone Deacetylase Binding Sequence-specific DNA Binding Ubiquitin-like Protein Ligase Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Protease Binding Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Protein Kinase Binding Nuclear Estrogen Receptor Binding Histone Acetyltransferase Binding Ubiquitin-like Protein Ligase Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Regulation Of Cell Growth Liver Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Proliferation Glandular Epithelial Cell Maturation Positive Regulation Of Immunoglobulin Production Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Lipid Metabolic Process Fatty Acid Biosynthetic Process Autophagy Apoptotic Process Immune Response Response To Unfolded Protein Muscle Organ Development Positive Regulation Of Cell Population Proliferation Regulation Of Autophagy Positive Regulation Of Autophagy Negative Regulation Of Myotube Differentiation Protein Transport Cell Differentiation Positive Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Exocrine Pancreas Development Regulation Of Protein Stability Protein Destabilization Cellular Response To Nutrient Positive Regulation Of TOR Signaling Positive Regulation Of Interleukin-6 Production Cellular Response To Insulin Stimulus Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Intracellular Triglyceride Homeostasis Positive Regulation Of Vascular Wound Healing Cellular Response To Vascular Endothelial Growth Factor Stimulus IRE1-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response ERAD Pathway Cellular Response To Glucose Starvation Positive Regulation Of Protein Import Into Nucleus Cholesterol Homeostasis Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Vascular Endothelial Growth Factor Receptor Signaling Pathway Neuron Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Fatty Acid Homeostasis Sterol Homeostasis Negative Regulation Of SMAD Protein Signal Transduction Adipose Tissue Development Epithelial Cell Maturation Involved In Salivary Gland Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Phospholipid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-4 Cellular Response To Peptide Hormone Stimulus Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Positive Regulation Of Plasma Cell Differentiation Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Acetylation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lactation Positive Regulation Of ERAD Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process	Regulation Of DNA-templated Transcription Estrogen Receptor Signaling Pathway Ribosome Disassembly Regulation Of Myoblast Differentiation Positive Regulation Of DNA-templated Transcription Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process
Pathways			ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases
GWAS		Esophageal cancer (squamous cell) ( 22960999) Esophageal squamous cell carcinoma ( 25129146) Heel bone mineral density ( 28869591) Mean arterial pressure ( 29403010) Pancreatic cancer ( 25086665) Serum alkaline phosphatase levels ( 33547301)	Alzheimer's disease (late onset) ( 24162737) Neuroticism ( 29255261)
Interacting Genes		22 interacting genes: ATF6 ATF6B CREBZF ESR1 FOS FUBP3 GLI1 H1-0 H1-10 HDGF MDM2 MTNR1B NR0B2 PCBD2 RBL2 SRSF1 SSX4 TRIP4 UBE2I UBE2V1 ZNF440 ZNF580	23 interacting genes: AR ASCC2 ASCC3 CREBBP EP300 ESR1 ESR2 GTF2A1 JUN NCOA1 NEK6 NFKB1 NR2F2 PAX9 PPARG RARA RELA RXRA SRF TBP THRB UBC XBP1
Entrez ID		7494	9325
HPRD ID		01908	05140
Ensembl ID		ENSG00000100219	ENSG00000103671
Uniprot IDs		B1AHH1 P17861	Q15650
PDB IDs		6R5Q 6R6G 6R6P 6R7Q	2E5O 8ALZ 8YEW 8YEY 8YFI 8YFJ 8YXW 8YXX
Enriched GO Terms of Interacting Partners?		Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Nucleoplasm Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process ATF6-mediated Unfolded Protein Response Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Chromatin Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II ER-nucleus Signaling Pathway DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coregulator Binding RNA Polymerase II Transcription Regulator Complex Double-stranded DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Animal Organ Regeneration Negative Regulation Of Nucleobase-containing Compound Metabolic Process Peroxisome Proliferator Activated Receptor Binding Transcription Repressor Complex Endoplasmic Reticulum Unfolded Protein Response RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Estrogen Stimulus SUMO Transferase Activity Transcription Cis-regulatory Region Binding Cellular Response To Reactive Oxygen Species Estrogen Receptor Signaling Pathway Response To Immobilization Stress Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Liver Regeneration Regeneration Sequence-specific Double-stranded DNA Binding Regulation Of Endoplasmic Reticulum Unfolded Protein Response Nuclear Estrogen Receptor Binding	Positive Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleoplasm Transcription Coactivator Binding Nuclear Receptor Activity Positive Regulation Of RNA Metabolic Process Chromatin Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Negative Regulation Of DNA-templated Transcription Intracellular Receptor Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Hormone-mediated Signaling Pathway Regulation Of MiRNA Metabolic Process Chromatin Binding DNA-binding Transcription Factor Activity Nucleobase-containing Compound Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Nuclear Receptor-mediated Signaling Pathway DNA Binding Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Response To Hormone Regulation Of MiRNA Transcription Nucleic Acid Metabolic Process Regulation Of RNA Metabolic Process Transcription Regulator Complex Chromatin DNA Binding Transcription Cis-regulatory Region Binding MRNA Transcription By RNA Polymerase II Enzyme Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Response To Lipid Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific MRNA Transcription Positive Regulation Of Metabolic Process RNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process
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