RAI1 and GATA1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		RAI1	GATA1
Gene Name		retinoic acid induced 1	GATA binding protein 1 (globin transcription factor 1)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Nucleus Nucleoplasm Transcription Factor Complex Transcriptional Repressor Complex
	Molecular Function	Zinc Ion Binding Enhancer Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding Enhancer Sequence-specific DNA Binding P53 Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Zinc Ion Binding DNA Binding, Bending Chromatin DNA Binding Sequence-specific DNA Binding C2H2 Zinc Finger Domain Binding
	Biological Process	Skeletal System Development Regulation Of Transcription From RNA Polymerase II Promoter Circadian Regulation Of Gene Expression Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription From RNA Polymerase II Promoter In Utero Embryonic Development Transcription From RNA Polymerase II Promoter Cell-cell Signaling Blood Coagulation Negative Regulation Of Cell Proliferation Male Gonad Development Regulation Of Glycoprotein Biosynthetic Process Regulation Of Definitive Erythrocyte Differentiation Erythrocyte Differentiation Megakaryocyte Differentiation Platelet Formation Basophil Differentiation Eosinophil Differentiation Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Proliferation Embryonic Hemopoiesis Eosinophil Fate Commitment Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Erythrocyte Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation Platelet Aggregation Transcriptional Activation By Promoter-enhancer Looping Dendritic Cell Differentiation Cellular Response To Thyroid Hormone Stimulus Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Parkinson's disease ( 21738487)
Protein-Protein Interactions		15 interactors: CASP2 CDKN1A DDIT3 GADD45A GATA1 GLI1 GSK3B LZTR1 MAML3 MAPK8IP2 PIN1 RPS6KA5 TESC TTR ZNF496	51 interactors: AKT1 ARID1A CASP3 CCDC24 CEBPE CREBBP FBF1 FLI1 FRS3 HDAC3 HDAC4 HDAC5 HEXIM2 HEY1 HOXA1 HSPA4 KRTAP10-5 KRTAP9-2 LMO2 MAPK1 MAPK3 MAPK6 MED1 PRKAA1 PRKAB2 RADIL RAI1 SMARCA4 SMARCB1 SMARCC1 SMARCC2 SMARCD1 SMARCE1 SP1 SPI1 SPIB SRA1 STAT3 SUMO1 TAF7 TAL1 TAX1BP3 TRIM25 TRIM29 ZBTB16 ZBTB22 ZDHHC17 ZFPM1 ZFPM2 ZNF521 ZZZ3
Entrez ID		10743	2623
HPRD ID		07406	02372
Ensembl ID		ENSG00000108557	ENSG00000102145
Uniprot IDs		Q7Z5J4	P15976
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Cellular Response To Stimulus Regulation Of Kinase Activity Cellular Response To Organic Substance Signaling Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Cell Communication Neurotrophin Signaling Pathway Negative Regulation Of Kinase Activity Cellular Response To Mechanical Stimulus ER Overload Response Cellular Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Programmed Cell Death Signal Transduction In Response To DNA Damage Positive Regulation Of Cell Death Negative Regulation Of Transferase Activity Signal Transduction Regulation Of Catalytic Activity Regulation Of Cellular Process Negative Regulation Of Protein Phosphorylation Response To Stimulus Response To Organic Substance Apoptotic Signaling Pathway Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Intracellular Signal Transduction Megakaryocyte Differentiation	Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Transcription, DNA-templated Positive Regulation Of Gene Expression RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Macromolecule Biosynthetic Process Gene Expression RNA Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Metabolic Process Biosynthetic Process Nucleosome Disassembly Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Negative Regulation Of Gene Expression Negative Regulation Of Cellular Metabolic Process Developmental Process Chromatin Organization Regulation Of Cellular Process Anatomical Structure Development Chromatin Remodeling Myeloid Cell Differentiation Chromatin Modification Cell Differentiation Multicellular Organismal Development Embryonic Organ Development Hemopoiesis Chromosome Organization Megakaryocyte Differentiation Immune System Development
Tagcloud ?		comprise coordinate degrade demonstration divalent dom3z eukaryotes exclusive exoribonuclease exoribonucleases homologue landscape messenger mutagenesis nucleases pilt pin pocket pombe possesses pyrophosphohydrolase rat1 refs schizosaccharomyces termination triphosphorylated unexpectedly xrn2 xrns	alls blasts cd3 cd45 comprised deregulation disrupted enable exploited fused haemopoietic immunocytochemical leukaemia leukaemic lymphoblastic lymphoid monocytes morphologically ordinately origin precursors rearrangement resembled sil tal tal1 transcripts unexplained unidentified
Tagcloud (Difference) ?		comprise coordinate degrade demonstration divalent dom3z eukaryotes exclusive exoribonuclease exoribonucleases homologue landscape messenger mutagenesis nucleases pilt pin pocket pombe possesses pyrophosphohydrolase rat1 refs schizosaccharomyces termination triphosphorylated unexpectedly xrn2 xrns	alls blasts cd3 cd45 comprised deregulation disrupted enable exploited fused haemopoietic immunocytochemical leukaemia leukaemic lymphoblastic lymphoid monocytes morphologically ordinately origin precursors rearrangement resembled sil tal tal1 transcripts unexplained unidentified
Tagcloud (Intersection) ?