RAI1 and GLI1

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		RAI1	GLI1
Gene Name		retinoic acid induced 1	GLI family zinc finger 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Nucleus Nucleoplasm Cytoplasm Cytosol Intracellular Membrane-bounded Organelle Primary Cilium Ciliary Tip Ciliary Base
	Molecular Function	Zinc Ion Binding Enhancer Binding	DNA Binding Chromatin Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Microtubule Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Skeletal System Development Regulation Of Transcription From RNA Polymerase II Promoter Circadian Regulation Of Gene Expression Negative Regulation Of Multicellular Organism Growth Positive Regulation Of Transcription, DNA-templated	Osteoblast Differentiation Transcription From RNA Polymerase II Promoter Smoothened Signaling Pathway Spermatogenesis Ventral Midline Development Positive Regulation Of Cell Proliferation Regulation Of Smoothened Signaling Pathway Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Proximal/distal Pattern Formation Cerebellar Cortex Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Pituitary Gland Development Lung Development Positive Regulation Of DNA Replication Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Digestive Tract Morphogenesis Notochord Regression Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways			Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Degradation of GLI1 by the proteasome GLI proteins bind promoters of Hh responsive genes to promote transcription
Drugs
Diseases
GWAS		Parkinson's disease ( 21738487)
Protein-Protein Interactions		15 interactors: CASP2 CDKN1A DDIT3 GADD45A GATA1 GLI1 GSK3B LZTR1 MAML3 MAPK8IP2 PIN1 RPS6KA5 TESC TTR ZNF496	12 interactors: CDK4 DYRK1A FEM1B GCC1 PRKAA2 RAI1 STK36 SUFU TRIM42 XBP1 ZIC1 ZIC2
Entrez ID		10743	2735
HPRD ID		07406	01311
Ensembl ID		ENSG00000108557	ENSG00000111087
Uniprot IDs		Q7Z5J4	B4DNF7 F5H6H8 P08151
PDB IDs			2GLI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Cellular Response To Stimulus Regulation Of Kinase Activity Cellular Response To Organic Substance Signaling Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Protein Kinase Activity Cell Communication Neurotrophin Signaling Pathway Negative Regulation Of Kinase Activity Cellular Response To Mechanical Stimulus ER Overload Response Cellular Response To Stress Positive Regulation Of Transferase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Programmed Cell Death Signal Transduction In Response To DNA Damage Positive Regulation Of Cell Death Negative Regulation Of Transferase Activity Signal Transduction Regulation Of Catalytic Activity Regulation Of Cellular Process Negative Regulation Of Protein Phosphorylation Response To Stimulus Response To Organic Substance Apoptotic Signaling Pathway Response To External Stimulus Regulation Of Transcription From RNA Polymerase II Promoter Response To Stress Intracellular Signal Transduction Megakaryocyte Differentiation	System Development Rhythmic Process Regulation Of Smoothened Signaling Pathway Fatty Acid Homeostasis Multicellular Organismal Development Regulation Of Gene Expression Anatomical Structure Development Positive Regulation Of Cellular Metabolic Process Epithelial Cell Maturation Circadian Rhythm Regulation Of Protein Import Into Nucleus Cellular Response To Glucose Starvation Regulation Of Signal Transduction Developmental Process Regulation Of Metabolic Process Regulation Of Protein Localization To Nucleus Organ Development Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Autophagy Regulation Of Signaling Regulation Of RNA Metabolic Process Anion Homeostasis Regulation Of Intracellular Protein Transport Positive Regulation Of Metabolic Process Nervous System Development Regulation Of Nitrogen Compound Metabolic Process Anatomical Structure Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of TOR Signaling Positive Regulation Of Gene Expression Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Lactation Positive Regulation Of Plasma Cell Differentiation Epithelial Cell Maturation Involved In Salivary Gland Development Serotonin Secretion, Neurotransmission Response To Insulin-like Growth Factor Stimulus Ammonium Transport Central Nervous System Development Regulation Of Transcription Factor Import Into Nucleus Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Regulation Of Intracellular Transport Cell Differentiation Involved In Salivary Gland Development Anatomical Structure Formation Involved In Morphogenesis Regulation Of Transcription, DNA-templated Neural Tube Closure Epithelium Development Negative Regulation Of Signal Transduction Regulation Of Nucleic Acid-templated Transcription
Tagcloud ?		comprise coordinate degrade demonstration divalent dom3z eukaryotes exclusive exoribonuclease exoribonucleases homologue landscape messenger mutagenesis nucleases pilt pin pocket pombe possesses pyrophosphohydrolase rat1 refs schizosaccharomyces termination triphosphorylated unexpectedly xrn2 xrns	alp biogenesis coactivators colia cyclopamine esc escs hedgehog hh hydroxycholesterol ia mineralization mitochondrial opn osteocalcin osteogenesis osteogenic osteoinductive osteopontin osteoprogenitor osterix oxysterol oxysterols peroxisome proliferator runt smo ss
Tagcloud (Difference) ?		comprise coordinate degrade demonstration divalent dom3z eukaryotes exclusive exoribonuclease exoribonucleases homologue landscape messenger mutagenesis nucleases pilt pin pocket pombe possesses pyrophosphohydrolase rat1 refs schizosaccharomyces termination triphosphorylated unexpectedly xrn2 xrns	alp biogenesis coactivators colia cyclopamine esc escs hedgehog hh hydroxycholesterol ia mineralization mitochondrial opn osteocalcin osteogenesis osteogenic osteoinductive osteopontin osteoprogenitor osterix oxysterol oxysterols peroxisome proliferator runt smo ss
Tagcloud (Intersection) ?