RAB33B and ATG16L1

Number of citations of the paper that reports this interaction (PubMedID 32960676)
55

Data Source:
BioGRID (pull down)

		RAB33B	ATG16L1
Description		RAB33B, member RAS oncogene family	autophagy related 16 like 1
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GO Annotations	Cellular Component	Golgi Membrane Endosome Golgi Apparatus Golgi Lumen Membrane Phagophore Assembly Site Membrane Presynapse	Autophagosome Membrane Cytoplasm Lysosome Lysosomal Membrane Endosome Autophagosome Cytosol Axoneme Endosome Membrane Membrane Axon Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex Endolysosome Membrane Synapse Sperm Midpiece Glutamatergic Synapse Vacuole-isolation Membrane Contact Site
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity	Protein Binding Ubiquitin-like Protein Transferase Activity Identical Protein Binding Protein-membrane Adaptor Activity GTPase Binding
	Biological Process	Autophagosome Assembly Regulation Of Cell Growth Intra-Golgi Vesicle-mediated Transport Autophagy Protein Transport Regulation Of Exocytosis Rab Protein Signal Transduction Protein Localization To Golgi Apparatus Protein Localization To Phagophore Assembly Site Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Golgi Organization Negative Regulation Of Constitutive Secretory Pathway Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER	Autophagosome Assembly C-terminal Protein Lipidation Autophagy Positive Regulation Of Autophagy Protein Transport Macroautophagy Microautophagy Hippocampus Development Corpus Callosum Development Protein Localization To Phagophore Assembly Site Negative Stranded Viral RNA Replication Defense Response To Virus Xenophagy Axonal Transport Dendrite Arborization Negative Regulation Of Dendrite Extension
Pathways		Intra-Golgi traffic TBC/RABGAPs RAB geranylgeranylation	Macroautophagy
Drugs
Diseases			Crohn's disease
GWAS			Bilirubin levels ( 31319653 31801373 32084209) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17435756 17554300 18587394 20570966 21102463 22412388 22936669 23128233 28067908) Inflammatory bowel disease ( 28067908) Pediatric autoimmune diseases ( 26301688) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		11 interacting genes: ACVR1 ATG16L1 ATG16L2 CCDC136 GOLGA2 RABEP1 RABGEF1 RUFY2 SIAH1 TGFBR1 USP6	20 interacting genes: APP ATG5 C3 CRYAA CSNK2A1 CSNK2A2 DEDD2 GAN IFT20 NLRP6 NOD1 NOD2 OPTN RAB33A RAB33B RIPK2 SETD7 TRAF3IP3 WIPI2 ZFP36
Entrez ID		83452	55054
HPRD ID		05808	16498
Ensembl ID		ENSG00000172007	ENSG00000085978
Uniprot IDs		A0A494C0Z5 Q9H082	E7EVC7 Q17RG0 Q676U5
PDB IDs		6Y09 6ZAY	4GDK 4GDL 4NAW 4TQ0 5D7G 5NPV 5NPW 5NUV 5ZYX 7F69 7MU2 7W36 7XFR 8ZQG
Enriched GO Terms of Interacting Partners?		Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Endosome Viral RNA Genome Replication Negative Stranded Viral RNA Replication Atg12-Atg5-Atg16 Complex Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Endocytosis Regulation Of Receptor-mediated Endocytosis Pharyngeal System Development Viral Genome Replication Transforming Growth Factor Beta Binding Recycling Endosome Phagophore Assembly Site Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Activin Receptor Signaling Pathway Ventricular Septum Morphogenesis Regulation Of Vesicle-mediated Transport Positive Regulation Of SMAD Protein Signal Transduction Protein Transport Growth Factor Binding SMAD Binding Endocardial Cushion Cell Fate Commitment Vacuole-isolation Membrane Contact Site Positive Regulation Of Epithelial To Mesenchymal Transition Establishment Of Protein Localization Organelle Assembly Reproductive Process Regulation Of SMAD Protein Signal Transduction Endocytic Vesicle Cardiac Septum Morphogenesis Early Endosome Regulation Of Receptor Internalization Positive Regulation Of Determination Of Dorsal Identity Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Negative Regulation Of Kit Signaling Pathway Negative Regulation Of Mast Cell Cytokine Production Axo-dendritic Transport Autophagosome C-terminal Protein Lipidation Regulation Of Apoptotic Signaling Pathway Developmental Process Involved In Reproduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis	Autophagy Regulation Of Macroautophagy Response To Stress Positive Regulation Of Interleukin-1 Beta Production Regulation Of Autophagy Positive Regulation Of Catabolic Process Positive Regulation Of Interleukin-1 Production Regulation Of Cytokine Production Regulation Of Defense Response Macroautophagy Regulation Of Innate Immune Response Positive Regulation Of Defense Response Positive Regulation Of Autophagy Positive Regulation Of Xenophagy Cell Death Regulation Of Interleukin-1 Beta Production Positive Regulation Of Macroautophagy Cellular Response To Muramyl Dipeptide Protein-containing Complex Regulation Of Interleukin-1 Production Response To Bacterium Intracellular Signal Transduction CARD Domain Binding Signal Transduction Innate Immune Response Immune System Process Programmed Cell Death Regulation Of Immune Response Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Stress-activated MAPK Cascade Defense Response To Bacterium Response To Muramyl Dipeptide Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Cytokine Production Golgi Apparatus Phagophore Assembly Site Membrane Defense Response To Symbiont Defense Response To Other Organism P38MAPK Cascade Protein Kinase CK2 Complex Protein Localization To Golgi Apparatus Regulation Of Apoptotic Process Autophagosome Assembly Positive Regulation Of Interleukin-6 Production Regulation Of Programmed Cell Death Positive Regulation Of JNK Cascade Negative Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Pattern Recognition Receptor Signaling Pathway Autophagosome Organization Immune Response
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