RAB33B and ATG16L1

Number of citations of the paper that reports this interaction (PMID 18448665)
45

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		RAB33B	ATG16L1
Gene Name		RAB33B, member RAS oncogene family	autophagy related 16-like 1 (S. cerevisiae)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Golgi Lumen Extracellular Vesicular Exosome	Autophagic Vacuole Membrane Autophagic Vacuole Axoneme Pre-autophagosomal Structure Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding	Protein Binding Identical Protein Binding
	Biological Process	Protein Targeting To Golgi Regulation Of Cell Growth Intracellular Protein Transport Intra-Golgi Vesicle-mediated Transport Autophagy Rab Protein Signal Transduction Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Golgi Organization Negative Regulation Of Constitutive Secretory Pathway Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER Regulation Of Autophagic Vacuole Assembly	Autophagic Vacuole Assembly Protein Transport Negative Stranded Viral RNA Replication Protein Homooligomerization
Pathways
Drugs
Diseases
GWAS			Crohn's disease ( 18587394 20570966 22936669 22412388 17435756 17554300 21102463 23128233)
Protein-Protein Interactions		7 interactors: ACVR1 ATG16L1 GOLGA2 RABEP1 RABGEF1 TGFBR1 USP6	6 interactors: APP ATG5 RAB33A RAB33B TMEM59 UBC
Entrez ID		83452	55054
HPRD ID		05808	16498
Ensembl ID		ENSG00000172007	ENSG00000085978
Uniprot IDs		Q9H082	E7EVC7 Q17RG0 Q53SV2 Q676U5
PDB IDs			4GDK 4GDL
Enriched GO Terms of Interacting Partners?		Pathway-restricted SMAD Protein Phosphorylation Pharyngeal System Development Activin Receptor Signaling Pathway Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Peptidyl-threonine Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Kit Signaling Pathway Endocardial Cushion Cell Fate Commitment Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Mesenchymal Cell Development Positive Regulation Of Catalytic Activity Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchymal Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Binding Positive Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Ameboidal-type Cell Migration Regulation Of GTPase Activity Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Mast Cell Degranulation Regulation Of Extrinsic Apoptotic Signaling Pathway Mesenchyme Development Mitral Valve Morphogenesis Negative Regulation Of Mast Cell Activation Involved In Immune Response Cardiac Muscle Cell Fate Commitment Heart Morphogenesis Mitral Valve Development Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Stem Cell Development Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Binding Positive Regulation Of Determination Of Dorsal Identity Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Parathyroid Gland Development Positive Regulation Of Hydrolase Activity Signal Transduction By Phosphorylation Negative Regulation Of Activin Receptor Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Negative Regulation Of Signal Transduction Atrial Septum Primum Morphogenesis Endocardial Cell Differentiation	Regulation Of Autophagy Regulation Of Autophagic Vacuole Assembly Autophagy Regulation Of Vacuole Organization Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Negative Regulation Of Type I Interferon Production Rab Protein Signal Transduction Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Intracellular Transport Negative Regulation Of Constitutive Secretory Pathway Negative Regulation Of Protein Ubiquitination Regulation Of Type I Interferon Production Catabolic Process Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER Synaptic Growth At Neuromuscular Junction Negative Regulation Of Protein Glycosylation In Golgi Notch Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Innate Immune Response Collateral Sprouting In Absence Of Injury Negative Regulation Of Cellular Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Viral Life Cycle Negative Regulation Of Protein Glycosylation Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Organelle Organization Regulation Of Protein Ubiquitination Negative Regulation Of Cytokine Production Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Process Ras Protein Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Cell Cycle Process Cellular Localization Regulation Of Cell Cycle Phase Transition Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Cellular Localization Cell Death Death Otolith Development Axon Choice Point Recognition
Tagcloud ?			1alpha 20a atg12 atg5 atg7 atg9a atgs autophagic autophagy becn1 cfos confirming ctsk decisive deregulation hif hypoxia hypoxic lc3 mirna mmp9 nfatc1 osteoclast p62 prime raw264 shrna traf6 utr
Tagcloud (Difference) ?			1alpha 20a atg12 atg5 atg7 atg9a atgs autophagic autophagy becn1 cfos confirming ctsk decisive deregulation hif hypoxia hypoxic lc3 mirna mmp9 nfatc1 osteoclast p62 prime raw264 shrna traf6 utr
Tagcloud (Intersection) ?