RAB33B and ATG16L2

Number of citations of the paper that reports this interaction (PubMedID 22082872)
41

Data Source:
BioGRID (pull down, two hybrid, affinity chromatography technology)

		RAB33B	ATG16L2
Description		RAB33B, member RAS oncogene family	autophagy related 16 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endosome Golgi Apparatus Golgi Lumen Membrane Phagophore Assembly Site Membrane Presynapse	Nucleoplasm Cytoplasm Autophagosome Cytosol Phagophore Assembly Site Membrane Atg12-Atg5-Atg16 Complex
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity
	Biological Process	Autophagosome Assembly Regulation Of Cell Growth Intra-Golgi Vesicle-mediated Transport Autophagy Protein Transport Regulation Of Exocytosis Rab Protein Signal Transduction Protein Localization To Golgi Apparatus Protein Localization To Phagophore Assembly Site Skeletal System Morphogenesis Regulation Of Epithelial Cell Proliferation Regulation Of Golgi Organization Negative Regulation Of Constitutive Secretory Pathway Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER	Autophagosome Assembly Autophagy Protein Transport Macroautophagy Negative Stranded Viral RNA Replication
Pathways		Intra-Golgi traffic TBC/RABGAPs RAB geranylgeranylation	Macroautophagy
Drugs
Diseases
GWAS			Crohn's disease ( 23266558 23850713) Non-albumin protein levels ( 29403010) Systemic lupus erythematosus ( 26663301)
Interacting Genes		11 interacting genes: ACVR1 ATG16L1 ATG16L2 CCDC136 GOLGA2 RABEP1 RABGEF1 RUFY2 SIAH1 TGFBR1 USP6	4 interacting genes: ATG5 RAB33A RAB33B TK1
Entrez ID		83452	89849
HPRD ID		05808	10959
Ensembl ID		ENSG00000172007	ENSG00000168010
Uniprot IDs		A0A494C0Z5 Q9H082	Q8NAA4
PDB IDs		6Y09 6ZAY
Enriched GO Terms of Interacting Partners?		Activin Receptor Complex Activin Receptor Activity, Type I Transforming Growth Factor Beta Receptor Activity, Type I Endosome Viral RNA Genome Replication Negative Stranded Viral RNA Replication Atg12-Atg5-Atg16 Complex Positive Regulation Of Cardiac Epithelial To Mesenchymal Transition Activin Binding Transmembrane Receptor Protein Serine/threonine Kinase Activity Regulation Of Endocytosis Regulation Of Receptor-mediated Endocytosis Pharyngeal System Development Viral Genome Replication Transforming Growth Factor Beta Binding Recycling Endosome Phagophore Assembly Site Membrane Regulation Of Postsynaptic Neurotransmitter Receptor Internalization Activin Receptor Signaling Pathway Ventricular Septum Morphogenesis Regulation Of Vesicle-mediated Transport Positive Regulation Of SMAD Protein Signal Transduction Protein Transport Growth Factor Binding SMAD Binding Endocardial Cushion Cell Fate Commitment Vacuole-isolation Membrane Contact Site Positive Regulation Of Epithelial To Mesenchymal Transition Establishment Of Protein Localization Organelle Assembly Reproductive Process Regulation Of SMAD Protein Signal Transduction Endocytic Vesicle Cardiac Septum Morphogenesis Early Endosome Regulation Of Receptor Internalization Positive Regulation Of Determination Of Dorsal Identity Vascular Endothelial Cell Proliferation Epicardium Morphogenesis Negative Regulation Of Kit Signaling Pathway Negative Regulation Of Mast Cell Cytokine Production Axo-dendritic Transport Autophagosome C-terminal Protein Lipidation Regulation Of Apoptotic Signaling Pathway Developmental Process Involved In Reproduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Proepicardium Development Angiogenesis Involved In Coronary Vascular Morphogenesis	Autophagosome Organization Autophagosome Assembly Rab Protein Signal Transduction Vacuole Organization Phagophore Assembly Site Membrane Cellular Component Assembly Thymidine Kinase Activity Organelle Assembly Antigen Processing And Presentation Otolith Development Positive Regulation Of Viral Translation Negative Regulation Of Constitutive Secretory Pathway Regulation Of Retrograde Vesicle-mediated Transport, Golgi To ER DNA Synthesis Involved In Mitotic DNA Replication Negative Regulation Of Autophagic Cell Death Phagophore Atg8-family Ligase Activity Negative Stranded Viral RNA Replication Response To Fluoride Cellular Response To Nitrosative Stress Thymidine Biosynthetic Process Positive Regulation Of Mucus Secretion Thymidine Metabolic Process Small GTPase-mediated Signal Transduction Positive Regulation Of Stress Granule Assembly Chaperone-mediated Autophagy Response To Iron(II) Ion Viral RNA Genome Replication Atg12-Atg5-Atg16 Complex Autophagy Regulation Of Mucus Secretion Response To Nitrosative Stress GTPase Activity Deoxyribonucleoside Monophosphate Biosynthetic Process Ventricular Cardiac Muscle Cell Development Cellular Response To Nitrogen Starvation GTP Binding Regulation Of Stress Granule Assembly Pyrimidine Nucleoside Metabolic Process Cardiac Muscle Cell Apoptotic Process Negative Thymic T Cell Selection Negative T Cell Selection Transferase Complex Aggrephagy Striated Muscle Cell Apoptotic Process Regulation Of Autophagosome Maturation Mucus Secretion Negative Regulation Of Transport Nucleotide Binding Negative Regulation Of Defense Response To Virus
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