DNMT1 and FBP1

Number of citations of the paper that reports this interaction (PubMedID 34854226)
41

Data Source:
BioGRID (pull down)

		DNMT1	FBP1
Description		DNA methyltransferase 1	fructose-bisphosphatase 1
Image
GO Annotations	Cellular Component	Heterochromatin Female Germ Cell Nucleus Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin Mitochondrion Germ Cell Nucleus	Extracellular Space Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	DNA Binding Chromatin Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity Transferase Activity Metal Ion Binding LncRNA Binding Promoter-specific Chromatin Binding	Catalytic Activity Protein Binding AMP Binding Hydrolase Activity Phosphatase Activity Fructose 1,6-bisphosphate 1-phosphatase Activity Phosphoric Ester Hydrolase Activity Identical Protein Binding Metal Ion Binding Monosaccharide Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Methylation Regulation Of Cell Population Proliferation Epigenetic Programming Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Cellular Response To Amino Acid Stimulus Chromosomal DNA Methylation Maintenance Following DNA Replication Cellular Response To Bisphenol A Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	Negative Regulation Of Transcription By RNA Polymerase II Carbohydrate Metabolic Process Fructose Metabolic Process Fructose 6-phosphate Metabolic Process Gluconeogenesis Regulation Of Gluconeogenesis Negative Regulation Of Cell Growth Fructose 1,6-bisphosphate Metabolic Process Response To Nutrient Levels Cellular Response To Insulin Stimulus Negative Regulation Of Glycolytic Process Negative Regulation Of Ras Protein Signal Transduction Cellular Response To Magnesium Ion Cellular Response To CAMP Cellular Response To Xenobiotic Stimulus Cellular Hyperosmotic Salinity Response Cellular Hypotonic Salinity Response Cellular Response To Raffinose Cellular Response To Phorbol 13-acetate 12-myristate
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation STAT3 nuclear events downstream of ALK signaling Defective pyroptosis Nuclear events stimulated by ALK signaling in cancer	Gluconeogenesis
Drugs		Procaine Azacitidine Procainamide Flucytosine Decitabine Palifosfamide Epigallocatechin gallate	Adenosine phosphate 2,5-Anhydroglucitol-1,6-Biphosphate {4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol Mdl-29951 Fructose-6-phosphate MB-07803 Managlinat dialanetil N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDE 2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE 2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE
Diseases			Fructose-1,6-bisphosphatase deficiency
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Immature fraction of reticulocytes ( 27863252) Narcolepsy ( 24204295) Offspring birth weight ( 31043758) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Colorectal or endometrial cancer ( 26621817) Obesity-related traits ( 23251661)
Interacting Genes		53 interacting genes: AKT1 BAZ2A BRAP CBX1 CEBPA CSNK2B DAXX DCAF5 DMAP1 DNMT3A DNMT3B DYNLL1 E2F6 EED EEF1A1 ENSA EZH2 FBP1 GSK3B H2BC3 H3-4 HDAC1 HDAC2 HELLS HMGB1 L3MBTL3 LASP1 LCOR MCRIP1 MECP2 NGRN NRIP1 PCLAF PCNA PEBP1 PHC2 PICK1 PRKAA2 RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SNHG6 SUMO2 SUV39H1 TRIM27 TRIM3 TSG101 UBB UBC YWHAQ	40 interacting genes: ACTN1 APC ASCC2 ASL ATP5MF AXIN2 BCL10 BCL2L1 BIN1 BMPR1A BRAF BUB1 CSNK1E CTNNA1 DCC DNMT1 DYNC1I1 ERBB2 FLCN FXR2 HDAC6 HSPA8 KLRC2 LNX1 MLH3 MSH2 NOTCH1 PCNX4 PIM2 POT1 PRKN PTK2 PTPRJ RB1 RELA RNF183 STK11 TERF1 TLR2 TRIM28
Entrez ID		1786	2203
HPRD ID		00532	01973
Ensembl ID		ENSG00000130816	ENSG00000165140
Uniprot IDs		I6L9H2 P26358 Q59FP7	P09467 Q2TU34
PDB IDs		3EPZ 3PTA 3SWR 4WXX 4YOC 4Z96 4Z97 5WVO 5YDR 6K3A 6L1F 6X9I 6X9J 6X9K 7SFC 7SFD 7SFE 7SFF 7SFG 7XI9 7XIB 8V9U 8XQC	1FTA 2FHY 2FIE 2FIX 2JJK 2VT5 2WBB 2WBD 2Y5K 2Y5L 3A29 3KBZ 3KC0 3KC1 4MJO 5LDZ 5PZQ 5PZR 5PZS 5PZT 5PZU 5PZV 5PZW 5PZX 5PZY 5PZZ 5Q00 5Q01 5Q02 5Q03 5Q04 5Q05 5Q06 5Q07 5Q08 5Q09 5Q0A 5Q0B 5ZWK 6LS5 6LW2 7C9Q 7CVH 7CVN 7CWE 7EZF 7EZP 7EZR 7WJV 7WVB 8XBK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Negative Regulation Of Metabolic Process Chromatin Remodeling Nucleoplasm Heterochromatin Formation Transcription Corepressor Activity Chromatin Binding Epigenetic Regulation Of Gene Expression Nucleus Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Heterochromatin Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Silencing Complex Cellular Response To Stress Facultative Heterochromatin Formation DNA Methylation-dependent Constitutive Heterochromatin Formation Transcription Corepressor Binding Enzyme Binding Regulation Of Transcription By RNA Polymerase II Constitutive Heterochromatin Formation Rhythmic Process DNA-binding Transcription Factor Binding Cellular Response To Xenobiotic Stimulus Regulation Of Proteolysis Epigenetic Programming Of Gene Expression DNA Binding Macromolecule Metabolic Process Response To Lipid Chromosome Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation ESC/E(Z) Complex Protein Tag Activity	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Regulation Of Nervous System Development Regulation Of Neurogenesis Positive Regulation Of Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Regulation Of Cell Development Cellular Response To Stress Ubiquitin Protein Ligase Binding Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nervous System Development Positive Regulation Of Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Cellular Component Organization Negative Regulation Of Apoptotic Process Regulation Of Cell Population Proliferation Regulation Of Primary Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Regulation Of Protein Localization Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Beta-catenin Binding Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Differentiation Regulation Of Protein Modification Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Metabolic Process Positive Regulation Of Multicellular Organismal Process Anatomical Structure Morphogenesis Positive Regulation Of Catabolic Process Regulation Of Phosphorylation Apoptotic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of Neurogenesis Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Positive Regulation Of Neurogenesis Programmed Cell Death Regulation Of Growth Cell Death
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