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DNMT1 and HDAC2
Number of citations of the paper that reports this interaction (PubMedID
10888872
)
0
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
DNMT1
HDAC2
Description
DNA methyltransferase 1
histone deacetylase 2
Image
GO Annotations
Cellular Component
Heterochromatin
Female Germ Cell Nucleus
Nucleus
Nucleoplasm
Replication Fork
Pericentric Heterochromatin
Mitochondrion
Germ Cell Nucleus
Histone Deacetylase Complex
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
NuRD Complex
Protein-containing Complex
ESC/E(Z) Complex
Sin3-type Complex
Molecular Function
DNA Binding
Chromatin Binding
RNA Binding
DNA (cytosine-5-)-methyltransferase Activity
Protein Binding
Methyltransferase Activity
Zinc Ion Binding
Methyl-CpG Binding
DNA-methyltransferase Activity
Transferase Activity
Metal Ion Binding
LncRNA Binding
Promoter-specific Chromatin Binding
Transcription Coregulator Binding
Chromatin Binding
RNA Binding
Histone Deacetylase Activity
Protein Binding
Hydrolase Activity
Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides
Deacetylase Activity
Enzyme Binding
Heat Shock Protein Binding
Nucleosomal DNA Binding
Protein Lysine Deacetylase Activity
Histone Binding
Histone Deacetylase Binding
NF-kappaB Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
DNA-binding Transcription Factor Binding
Histone Deacetylase Activity, Hydrolytic Mechanism
Protein Decrotonylase Activity
Histone Decrotonylase Activity
Protein De-2-hydroxyisobutyrylase Activity
Protein Lysine Delactylase Activity
Promoter-specific Chromatin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Chromatin Organization
DNA Methylation-dependent Constitutive Heterochromatin Formation
DNA-templated Transcription
Regulation Of Gene Expression
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Methylation
Regulation Of Cell Population Proliferation
Epigenetic Programming Of Gene Expression
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
Negative Regulation Of DNA-templated Transcription
Cellular Response To Amino Acid Stimulus
Chromosomal DNA Methylation Maintenance Following DNA Replication
Cellular Response To Bisphenol A
Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching
Negative Regulation Of Transcription By RNA Polymerase II
Response To Amphetamine
Cardiac Muscle Hypertrophy
Chromatin Organization
Chromatin Remodeling
Positive Regulation Of Cell Population Proliferation
Response To Xenobiotic Stimulus
Epidermal Cell Differentiation
Positive Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Transcription By Competitive Promoter Binding
Negative Regulation Of Neuron Projection Development
Dendrite Development
Negative Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Caffeine
Heterochromatin Formation
Response To Lipopolysaccharide
Positive Regulation Of Interleukin-1 Production
Positive Regulation Of Tumor Necrosis Factor Production
Circadian Regulation Of Gene Expression
Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Cellular Response To Heat
Response To Nicotine
Protein Modification Process
Response To Cocaine
Odontogenesis Of Dentin-containing Tooth
Regulation Of Cell Fate Specification
Embryonic Digit Morphogenesis
Negative Regulation Of Apoptotic Process
Positive Regulation Of Proteolysis
Negative Regulation Of DNA-templated Transcription
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Behavioral Response To Ethanol
Rhythmic Process
Positive Regulation Of Oligodendrocyte Differentiation
Progesterone Receptor Signaling Pathway
Response To Hyperoxia
Hair Follicle Placode Formation
Negative Regulation Of Dendritic Spine Development
Eyelid Development In Camera-type Eye
Fungiform Papilla Formation
Cellular Response To Hydrogen Peroxide
Cellular Response To Retinoic Acid
Cellular Response To Transforming Growth Factor Beta Stimulus
Response To Alcohol
Positive Regulation Of Male Mating Behavior
Negative Regulation Of Stem Cell Population Maintenance
Positive Regulation Of Stem Cell Population Maintenance
Cellular Response To Dopamine
Response To Amyloid-beta
Regulation Of Stem Cell Differentiation
Pathways
PRC2 methylates histones and DNA
NoRC negatively regulates rRNA expression
SUMOylation of DNA methylation proteins
DNA methylation
STAT3 nuclear events downstream of ALK signaling
Defective pyroptosis
Nuclear events stimulated by ALK signaling in cancer
p75NTR negatively regulates cell cycle via SC1
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
Notch-HLH transcription pathway
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
SUMOylation of chromatin organization proteins
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Regulation of MECP2 expression and activity
MECP2 regulates neuronal receptors and channels
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
EGR2 and SOX10-mediated initiation of Schwann cell myelination
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Potential therapeutics for SARS
STAT3 nuclear events downstream of ALK signaling
Negative Regulation of CDH1 Gene Transcription
Factors involved in megakaryocyte development and platelet production
Regulation of endogenous retroelements by KRAB-ZFP proteins
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs
Procaine
Azacitidine
Procainamide
Flucytosine
Decitabine
Palifosfamide
Epigallocatechin gallate
Pravastatin
Lovastatin
Theophylline
Valproic acid
Valproic acid
Simvastatin
Atorvastatin
Fluvastatin
Aminophylline
Decitabine
Oxtriphylline
Vorinostat
Vorinostat
Belinostat
Pracinostat
Romidepsin
Romidepsin
Panobinostat
Phenylbutyric acid
Tixocortol
Mocetinostat
Entinostat
Abexinostat
Givinostat
Pyroxamide
Diseases
GWAS
Appendicular lean mass (
33097823
)
Birth weight (
31043758
)
Immature fraction of reticulocytes (
27863252
)
Narcolepsy (
24204295
)
Offspring birth weight (
31043758
)
Reticulocyte count (
27863252
)
Reticulocyte fraction of red cells (
27863252
)
Waist-hip index (
34021172
)
Waist-to-hip ratio adjusted for BMI (
34021172
)
Event free survival in diffuse large B-cell lymphoma treated with immunochemotherapy (
26460308
)
Metabolite levels (
23823483
)
Interacting Genes
53 interacting genes:
AKT1
BAZ2A
BRAP
CBX1
CEBPA
CSNK2B
DAXX
DCAF5
DMAP1
DNMT3A
DNMT3B
DYNLL1
E2F6
EED
EEF1A1
ENSA
EZH2
FBP1
GSK3B
H2BC3
H3-4
HDAC1
HDAC2
HELLS
HMGB1
L3MBTL3
LASP1
LCOR
MCRIP1
MECP2
NGRN
NRIP1
PCLAF
PCNA
PEBP1
PHC2
PICK1
PRKAA2
RB1
RGS6
RPS6KA6
RUNX1
RUNX1T1
SETD7
SNHG6
SUMO2
SUV39H1
TRIM27
TRIM3
TSG101
UBB
UBC
YWHAQ
97 interacting genes:
ANTXR1
APPL1
ARID4A
AURKA
BRCA1
BRMS1
BRMS1L
BUB3
CDC20
CDH1
CDKN1A
CDYL
CEBPA
CHFR
CIRSR
CSNK2A1
CSNK2A2
CTBP1
CUL4B
CYTOR
DAXX
DDX20
DMAP1
DNMT1
DNMT3B
EED
EID2
ERCC6
FKBP3
GATA3
H2AC1
H2AC20
H2BC21
H3-4
H3C1
HDAC1
HDAC10
HDAC7
HIF1A
HIF1AN
HOPX
IFRD1
IKZF1
IKZF4
ING1
JUP
MAD1L1
MBD2
MTA1
MXD1
NACC2
NRIP1
PA2G4
PADI4
PHB2
PHF21A
PIAS4
PML
PPARD
PPP1R8
PTMA
RBBP4
RBBP7
RBP1
RCOR1
RELA
RFX5
RUNX3
SALL1
SAP30
SETDB1
SIN3A
SMAD2
SMARCA5
SMYD1
SNW1
SP1
SP3
SPEN
SS18L1
STAT3
SUMO2
SUV39H1
SYK
TFCP2
THRA
THRB
TMEM132D
TOP2A
TOP2B
TP53
UBC
USP4
VHL
YY1
ZBTB16
ZNF461
Entrez ID
1786
3066
HPRD ID
00532
05521
Ensembl ID
ENSG00000130816
ENSG00000196591
Uniprot IDs
I6L9H2
P26358
Q59FP7
Q92769
PDB IDs
3EPZ
3PTA
3SWR
4WXX
4YOC
4Z96
4Z97
5WVO
5YDR
6K3A
6L1F
6X9I
6X9J
6X9K
7SFC
7SFD
7SFE
7SFF
7SFG
7XI9
7XIB
8V9U
8XQC
3MAX
4LXZ
4LY1
5IWG
5IX0
6G3O
6WBW
6WBZ
6WHN
6WHO
6WHQ
6WHZ
6WI3
6XDM
6XEB
6XEC
7JS8
7KBG
7KBH
7LTG
7LTK
7LTL
7MOS
7MOT
7MOX
7MOY
7MOZ
7ZZO
7ZZP
7ZZR
7ZZS
7ZZT
7ZZU
7ZZW
8A0B
8BPA
8BPB
8BPC
8C60
9DTQ
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Gene Expression, Epigenetic
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Chromatin Organization
Negative Regulation Of Metabolic Process
Chromatin Remodeling
Nucleoplasm
Heterochromatin Formation
Transcription Corepressor Activity
Chromatin Binding
Epigenetic Regulation Of Gene Expression
Nucleus
Negative Regulation Of Transcription By RNA Polymerase II
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Heterochromatin
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Chromatin Silencing Complex
Cellular Response To Stress
Facultative Heterochromatin Formation
DNA Methylation-dependent Constitutive Heterochromatin Formation
Transcription Corepressor Binding
Enzyme Binding
Regulation Of Transcription By RNA Polymerase II
Constitutive Heterochromatin Formation
Rhythmic Process
DNA-binding Transcription Factor Binding
Cellular Response To Xenobiotic Stimulus
Regulation Of Proteolysis
Epigenetic Programming Of Gene Expression
DNA Binding
Macromolecule Metabolic Process
Response To Lipid
Chromosome
Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation
ESC/E(Z) Complex
Protein Tag Activity
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of RNA Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of RNA Biosynthetic Process
Negative Regulation Of Transcription By RNA Polymerase II
Nucleus
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin Organization
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Macromolecule Metabolic Process
Nucleoplasm
Regulation Of Primary Metabolic Process
Regulation Of Metabolic Process
Chromatin Remodeling
DNA Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Transcription Corepressor Activity
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of DNA-templated Transcription
Sin3-type Complex
Histone Deacetylase Binding
Chromatin Binding
Positive Regulation Of Metabolic Process
Regulation Of Developmental Process
Positive Regulation Of Macromolecule Biosynthetic Process
Histone Deacetylase Complex
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Developmental Process
Negative Regulation Of Stem Cell Population Maintenance
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Epigenetic Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Transcription Repressor Complex
Negative Regulation Of Developmental Process
Negative Regulation Of Gene Expression, Epigenetic
Heterochromatin Formation
Protein-containing Complex
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Regulation Of Cell Differentiation
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