DNMT1 and RGS6

Number of citations of the paper that reports this interaction (PubMedID 14734556)
0

Data Source:
BioGRID (pull down)

		DNMT1	RGS6
Description		DNA methyltransferase 1	regulator of G protein signaling 6
Image
GO Annotations	Cellular Component	Heterochromatin Female Germ Cell Nucleus Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin Mitochondrion Germ Cell Nucleus	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Neuron Projection
	Molecular Function	DNA Binding Chromatin Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity Transferase Activity Metal Ion Binding LncRNA Binding Promoter-specific Chromatin Binding	GTPase Activity GTPase Activator Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Methylation Regulation Of Cell Population Proliferation Epigenetic Programming Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Cellular Response To Amino Acid Stimulus Chromosomal DNA Methylation Maintenance Following DNA Replication Cellular Response To Bisphenol A Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation STAT3 nuclear events downstream of ALK signaling Defective pyroptosis Nuclear events stimulated by ALK signaling in cancer	G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		Procaine Azacitidine Procainamide Flucytosine Decitabine Palifosfamide Epigallocatechin gallate
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Immature fraction of reticulocytes ( 27863252) Narcolepsy ( 24204295) Offspring birth weight ( 31043758) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Aspartate aminotransferase levels ( 33547301) Autism spectrum disorder or schizophrenia ( 28540026) Bone mineral density (hip) ( 30172743) C-reactive protein levels ( 21300955 33339817 30388399) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cutaneous psoriasis ( 26626624) Economic and political preferences (environmentalism) ( 22566634) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Femur bone mineral density x serum urate levels interaction ( 34046847) General risk tolerance (MTAG) ( 30643258) Heart rate ( 28610988) Heart rate increase in response to exercise ( 29497042) Heart rate response to exercise ( 29769521) Heart rate response to recovery post exercise ( 29769521) Heart rate response to recovery post exercise (30 sec) ( 29497042) Heart rate response to recovery post exercise (40 sec) ( 29497042) Heart rate response to recovery post exercise (50 sec) ( 29497042) Heart rate variability traits (RMSSD) ( 28613276) Heart rate variability traits (SDNN) ( 28613276) Intracranial aneurysm ( 29531279) Liver enzyme levels (alkaline phosphatase) ( 33972514) Neuroticism ( 29255261) Night sleep phenotypes ( 27126917) Obesity (extreme) ( 21935397) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroglobulin levels ( 29678681) Resting heart rate ( 29769521 27798624) Schizophrenia ( 28991256 25056061 30285260 29483656) Serum alkaline phosphatase levels ( 33547301) Small cell lung carcinoma ( 28604730) Smoking cessation ( 20811658) Systolic blood pressure ( 30578418 30224653) Transverse temporal cortex volume ( 31530798) Yang-deficiency constitution ( 25533513)
Interacting Genes		53 interacting genes: AKT1 BAZ2A BRAP CBX1 CEBPA CSNK2B DAXX DCAF5 DMAP1 DNMT3A DNMT3B DYNLL1 E2F6 EED EEF1A1 ENSA EZH2 FBP1 GSK3B H2BC3 H3-4 HDAC1 HDAC2 HELLS HMGB1 L3MBTL3 LASP1 LCOR MCRIP1 MECP2 NGRN NRIP1 PCLAF PCNA PEBP1 PHC2 PICK1 PRKAA2 RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SNHG6 SUMO2 SUV39H1 TRIM27 TRIM3 TSG101 UBB UBC YWHAQ	4 interacting genes: DMAP1 DNMT1 GNB5 STMN2
Entrez ID		1786	9628
HPRD ID		00532	04871
Ensembl ID		ENSG00000130816	ENSG00000182732
Uniprot IDs		I6L9H2 P26358 Q59FP7	B7Z2A0 B7Z2N1 P49758 Q2M3K2
PDB IDs		3EPZ 3PTA 3SWR 4WXX 4YOC 4Z96 4Z97 5WVO 5YDR 6K3A 6L1F 6X9I 6X9J 6X9K 7SFC 7SFD 7SFE 7SFF 7SFG 7XI9 7XIB 8V9U 8XQC	2ES0
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Negative Regulation Of Metabolic Process Chromatin Remodeling Nucleoplasm Heterochromatin Formation Transcription Corepressor Activity Chromatin Binding Epigenetic Regulation Of Gene Expression Nucleus Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Heterochromatin Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Silencing Complex Cellular Response To Stress Facultative Heterochromatin Formation DNA Methylation-dependent Constitutive Heterochromatin Formation Transcription Corepressor Binding Enzyme Binding Regulation Of Transcription By RNA Polymerase II Constitutive Heterochromatin Formation Rhythmic Process DNA-binding Transcription Factor Binding Cellular Response To Xenobiotic Stimulus Regulation Of Proteolysis Epigenetic Programming Of Gene Expression DNA Binding Macromolecule Metabolic Process Response To Lipid Chromosome Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation ESC/E(Z) Complex Protein Tag Activity	Replication Fork Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching Chromosomal DNA Methylation Maintenance Following DNA Replication Protein K33-linked Ubiquitination GTPase Activator Complex G-protein Gamma-subunit Binding Dark Adaptation Cytosol To ERGIC Protein Transport Protein Localization To ERGIC COPI-coated Vesicle Budding DNA-methyltransferase Activity Germ Cell Nucleus DNA (cytosine-5-)-methyltransferase Activity Light Adaption Cellular Response To Bisphenol A Vesicle Targeting, To, From Or Within Golgi Regulation Of Phenotypic Switching Positive Regulation Of Microtubule Depolymerization Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Response To Bisphenol A COPI Coating Of Golgi Vesicle Gamma-secretase Complex Negative Regulation Of Voltage-gated Calcium Channel Activity Cell Tip Positive Regulation Of Protein Transport
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