DNMT1 and SETD7

Number of citations of the paper that reports this interaction (PubMedID 21151116)
31

Data Source:
BioGRID (enzymatic study)

		DNMT1	SETD7
Description		DNA methyltransferase 1	SET domain containing 7, histone lysine methyltransferase
Image
GO Annotations	Cellular Component	Heterochromatin Female Germ Cell Nucleus Nucleus Nucleoplasm Replication Fork Pericentric Heterochromatin Mitochondrion Germ Cell Nucleus	Nucleus Nucleoplasm Chromosome Nucleolus
	Molecular Function	DNA Binding Chromatin Binding RNA Binding DNA (cytosine-5-)-methyltransferase Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Methyl-CpG Binding DNA-methyltransferase Activity Transferase Activity Metal Ion Binding LncRNA Binding Promoter-specific Chromatin Binding	P53 Binding Chromatin Binding Protein Binding Methyltransferase Activity Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Histone H3 Methyltransferase Activity Histone H3K4 Monomethyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation DNA-templated Transcription Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Methylation Regulation Of Cell Population Proliferation Epigenetic Programming Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Cellular Response To Amino Acid Stimulus Chromosomal DNA Methylation Maintenance Following DNA Replication Cellular Response To Bisphenol A Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation Involved In Phenotypic Switching	Regulation Of DNA Repair Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription DNA Damage Response Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Methylation Response To Ethanol Positive Regulation Of DNA-templated Transcription Heterochromatin Organization Response To Alcohol
Pathways		PRC2 methylates histones and DNA NoRC negatively regulates rRNA expression SUMOylation of DNA methylation proteins DNA methylation STAT3 nuclear events downstream of ALK signaling Defective pyroptosis Nuclear events stimulated by ALK signaling in cancer	PKMTs methylate histone lysines
Drugs		Procaine Azacitidine Procainamide Flucytosine Decitabine Palifosfamide Epigallocatechin gallate	S-adenosyl-L-homocysteine
Diseases
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Immature fraction of reticulocytes ( 27863252) Narcolepsy ( 24204295) Offspring birth weight ( 31043758) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Diastolic blood pressure in combination therapy (beta blocker and thiazide diuretic) ( 29097388) Ferritin levels ( 33491795) Lean body mass ( 28552196) Salty taste perception in obesity with metabolic syndrome ( 31005965) Serum lycopene concentrations ( 26861389)
Interacting Genes		53 interacting genes: AKT1 BAZ2A BRAP CBX1 CEBPA CSNK2B DAXX DCAF5 DMAP1 DNMT3A DNMT3B DYNLL1 E2F6 EED EEF1A1 ENSA EZH2 FBP1 GSK3B H2BC3 H3-4 HDAC1 HDAC2 HELLS HMGB1 L3MBTL3 LASP1 LCOR MCRIP1 MECP2 NGRN NRIP1 PCLAF PCNA PEBP1 PHC2 PICK1 PRKAA2 RB1 RGS6 RPS6KA6 RUNX1 RUNX1T1 SETD7 SNHG6 SUMO2 SUV39H1 TRIM27 TRIM3 TSG101 UBB UBC YWHAQ	32 interacting genes: A1BG ATG16L1 DNMT1 E2F1 ESR1 H3-3A H3-4 H3C1 H3C14 H4C1 HCFC1 KLF4 L3MBTL1 MDM2 NR2F2 OGT OTUB1 PPP1R12A PRKAR1A RELA RIOK1 SERTAD1 SIRT1 SMAD7 SOX2 STAT3 STEAP3 TAF10 TAF7 TP53 TRIM21 UBC
Entrez ID		1786	80854
HPRD ID		00532	16226
Ensembl ID		ENSG00000130816	ENSG00000145391
Uniprot IDs		I6L9H2 P26358 Q59FP7	B5MCZ8 D6RJA0 Q8WTS6
PDB IDs		3EPZ 3PTA 3SWR 4WXX 4YOC 4Z96 4Z97 5WVO 5YDR 6K3A 6L1F 6X9I 6X9J 6X9K 7SFC 7SFD 7SFE 7SFF 7SFG 7XI9 7XIB 8V9U 8XQC	1H3I 1MT6 1MUF 1N6A 1N6C 1O9S 1XQH 2F69 3CBM 3CBO 3CBP 3M53 3M54 3M55 3M56 3M57 3M58 3M59 3M5A 3OS5 3VUZ 3VV0 4E47 4J7F 4J7I 4J83 4J8O 4JDS 4JLG 5AYF 5EG2 5YLT
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Chromatin Organization Negative Regulation Of Metabolic Process Chromatin Remodeling Nucleoplasm Heterochromatin Formation Transcription Corepressor Activity Chromatin Binding Epigenetic Regulation Of Gene Expression Nucleus Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Heterochromatin Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Chromatin Silencing Complex Cellular Response To Stress Facultative Heterochromatin Formation DNA Methylation-dependent Constitutive Heterochromatin Formation Transcription Corepressor Binding Enzyme Binding Regulation Of Transcription By RNA Polymerase II Constitutive Heterochromatin Formation Rhythmic Process DNA-binding Transcription Factor Binding Cellular Response To Xenobiotic Stimulus Regulation Of Proteolysis Epigenetic Programming Of Gene Expression DNA Binding Macromolecule Metabolic Process Response To Lipid Chromosome Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation ESC/E(Z) Complex Protein Tag Activity	Chromatin Organization Nucleoplasm Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Negative Regulation Of RNA Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Regulation Of RNA Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Chromatin Remodeling Protein-DNA Complex Assembly Negative Regulation Of Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Metabolic Process Negative Regulation Of Gene Expression DNA-templated Transcription Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Promoter-specific Chromatin Binding Positive Regulation Of Biosynthetic Process Regulation Of MiRNA Transcription Chromatin DNA Binding Regulation Of Cell Differentiation Nucleobase-containing Compound Biosynthetic Process Regulation Of Developmental Process Transcription Cis-regulatory Region Binding Structural Constituent Of Chromatin Chromatin DNA Binding Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction
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