APOL2 and PANX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APOL2	PANX1
Description		apolipoprotein L2	pannexin 1
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Membrane Bleb Protein-containing Complex
	Molecular Function	Signaling Receptor Binding Protein Binding High-density Lipoprotein Particle Binding Lipid Binding	Protease Binding Actin Binding Signaling Receptor Binding Structural Molecule Activity Gap Junction Channel Activity Monoatomic Anion Channel Activity Calcium Channel Activity ATP Transmembrane Transporter Activity Protein Binding Channel Activity Wide Pore Channel Activity Leak Channel Activity Identical Protein Binding Transmembrane Transporter Binding Protein-containing Complex Binding Actin Filament Binding Gap Junction Hemi-channel Activity Scaffold Protein Binding
	Biological Process	Lipid Metabolic Process Lipid Transport Acute-phase Response Cholesterol Metabolic Process Lipoprotein Metabolic Process Maternal Process Involved In Female Pregnancy	Response To Ischemia Monoatomic Ion Transport Monoatomic Cation Transport Calcium Ion Transport Cell-cell Signaling ATP Transport Cell Differentiation Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Response To ATP Monoatomic Ion Transmembrane Transport Oogenesis Positive Regulation Of Macrophage Cytokine Production Calcium Ion Transmembrane Transport Monoatomic Anion Transmembrane Transport
Pathways			Electric Transmission Across Gap Junctions The NLRP3 inflammasome High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Mechanical load activates signaling by PIEZO1 and integrins in osteocytes
Drugs			Probenecid
Diseases
GWAS		Epigenetic age acceleration in alcohol use disorder ( 31466081)	Alanine aminotransferase levels ( 33339817 33547301 34315874) Alanine transaminase levels ( 29403010) Aspartate aminotransferase levels ( 29403010 33339817 33547301 34315874) Autoimmune thyroid disease ( 32581359) Liver enzyme levels (alanine transaminase) ( 33972514) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		38 interacting genes: AIG1 APOC2 APOC4 AR BSND CISD2 CYBC1 EBAG9 ELOVL4 EMP1 ERGIC3 FAM209A FAM210B GET1 GJB5 ITGB2 KCNA1 LMNA MARCHF3 MFF MGST3 PANX1 PSCA SFXN5 SIT1 SLC18A1 SLC26A6 SLC35H1 STX1A STX2 TIMMDC1 TMED8 TMEM139 TMEM45B TMEM52B TMEM60 USE1 YIPF6	16 interacting genes: APOA2 APOL2 AQP2 BCL2L2 BUD31 CFHR5 CLCA4 FAXDC2 FDFT1 GNAS P2RX7 SLC38A7 TMEM229B TNF VAMP5 WFDC2
Entrez ID		23780	24145
HPRD ID		06263	10526
Ensembl ID		ENSG00000128335	ENSG00000110218
Uniprot IDs		Q9BQE5	Q96RD7
PDB IDs		7LF8	6LTN 6LTO 6M02 6M66 6M67 6M68 6V6D 6WBF 6WBG 6WBI 6WBK 6WBL 6WBM 6WBN 7DWB 7F8J 7F8N 7F8O 7WSV 8GTS 8GTT 8GYO
Enriched GO Terms of Interacting Partners?		Membrane SNAP Receptor Activity Endoplasmic Reticulum SNARE Complex	Sterol Metabolic Process Channel Activity High-density Lipoprotein Particle Binding Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Lipid Catabolic Process Renal Water Homeostasis Disordered Domain Specific Binding Extrinsic Apoptotic Signaling Pathway Multicellular Organismal-level Water Homeostasis Lipoprotein Metabolic Process Regulation Of Production Of Molecular Mediator Of Immune Response Negative Regulation Of Cytokine Production Involved In Immune Response Sterol Biosynthetic Process Squalene Synthase [NAD(P)H] Activity Response To Fluid Shear Stress Response To Bacterium Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis L-asparagine:sodium Symporter Activity L-glutamine:sodium Symporter Activity Positive Regulation Of Phagocytosis Peptidyl-methionine Modification Regulation Of Lipid Catabolic Process Cellular Response To Amyloid-beta Alcohol Metabolic Process Extracellular Region High-density Lipoprotein Particle Receptor Binding Positive Regulation Of Catabolic Process Response To Amyloid-beta Lipid Biosynthetic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cholesterol Import Lumenal Side Of Membrane Response To Stress Cellular Response To Mercury Ion Cellular Response To Water Deprivation Multicellular Organismal-level Chemical Homeostasis Glycerol Transmembrane Transporter Activity Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Mu-type Opioid Receptor Binding Regulation Of Protein Secretion Positive Regulation Of Bleb Assembly Positive Regulation Of Interleukin-1 Production Regulation Of Amine Transport
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