GJA8 and TJP1

Number of citations of the paper that reports this interaction (PMID 12808044)
34

Data Source:
HPRD (in vivo, in vitro)

		GJA8	TJP1
Gene Name		gap junction protein, alpha 8, 50kDa	tight junction protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Connexon Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Adherens Junction Gap Junction Tight Junction Intercalated Disc Basolateral Plasma Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Apical Junction Complex Apical Part Of Cell Intercellular Canaliculus
	Molecular Function	Gap Junction Channel Activity Channel Activity	Protein Binding Calmodulin Binding Protein C-terminus Binding Protein Domain Specific Binding
	Biological Process	Lens Development In Camera-type Eye Transport Cell-cell Signaling Visual Perception Protein Homooligomerization Transmembrane Transport	Blastocyst Formation Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell-cell Junction Assembly Sensory Perception Of Sound Response To Lipopolysaccharide Hippo Signaling Response To Drug Negative Regulation Of Vascular Permeability Response To Ethanol Membrane Organization Response To Magnetism Cellular Response To Glucose Stimulus Establishment Of Endothelial Intestinal Barrier Cell-cell Signaling Involved In Cell-cell Junction Organization
Pathways		Gap junction assembly Gap junction trafficking and regulation Gap junction trafficking	Apoptotic cleavage of cell adhesion proteins c-src mediated regulation of Cx43 function and closure of gap junctions Apoptotic cleavage of cellular proteins Signaling by Hippo Gap junction trafficking and regulation Programmed Cell Death Apoptotic execution phase Regulation of gap junction activity
Drugs
Diseases
GWAS			Corneal structure ( 23291589) Response to antipsychotic treatment ( 23241943)
Protein-Protein Interactions		2 interactors: MIP TJP1	38 interactors: ACTA1 ACTN4 ARVCF CGN CLDN1 CLDN16 CLDN2 CLDN3 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CNKSR2 CTNNA1 CTTN EGFR F11R GJA1 GJA3 GJA8 GJB3 GJC1 GJD3 GRIN1 GRIN2D HSP90AA1 JAM2 JAM3 KHDRBS1 KIRREL MLLT4 PTPN14 TJP2 TJP3 TRPC4 UBN1 YBX3
Entrez ID		2703	7082
HPRD ID		02939	03002
Ensembl ID		ENSG00000121634	ENSG00000104067
Uniprot IDs		P48165	G3V1L9 Q07157 Q6MZU1
PDB IDs			2H2B 2H2C 2H3M 2JWE 2KXR 2KXS 2RCZ 3CYY 3LH5 3SHU 3SHW 3TSV 3TSW 3TSZ
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Involved In Cell-cell Junction Organization Response To Magnetism Canalicular Bile Acid Transport Cellular Chemical Homeostasis Protein Processing Involved In Protein Targeting To Mitochondrion Establishment Of Endothelial Intestinal Barrier Bile Acid Secretion Glycerol Transport Cellular Homeostasis Polyol Transport Mitochondrial Protein Processing Negative Regulation Of Vascular Permeability Cellular Water Homeostasis Sensory Perception Chemical Homeostasis Establishment Of Endothelial Barrier Hippo Signaling Neurological System Process Bile Acid And Bile Salt Transport Cell Volume Homeostasis Regulation Of Vascular Permeability Blastocyst Formation Homeostatic Process Water Transport Endothelial Cell Development Fluid Transport Carbohydrate Transmembrane Transport Acid Secretion Cellular Response To Glucose Stimulus Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Water Homeostasis Protein Targeting To Mitochondrion Protein Localization To Mitochondrion Execution Phase Of Apoptosis Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Endothelial Cell Differentiation Endothelium Development Lens Development In Camera-type Eye Blastocyst Development Cell-cell Junction Assembly Carbohydrate Transport Response To Glucose Monocarboxylic Acid Transport Response To Ethanol Mitochondrial Transport Sensory Perception Of Sound Visual Perception Sensory Perception Of Light Stimulus Sensory Perception Of Mechanical Stimulus	Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cell-cell Junction Organization Cell Adhesion Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Junction Assembly Cell-cell Junction Assembly Gap Junction Assembly Cell Development Establishment Of Endothelial Intestinal Barrier Anatomical Structure Development Cellular Component Assembly Developmental Process Epithelial Cell Development Apical Junction Assembly Establishment Of Endothelial Barrier Endothelium Development Neuron Projection Development Regulation Of Body Fluid Levels Response To Abiotic Stimulus Regulation Of Actin Filament-based Process Anatomical Structure Morphogenesis Tight Junction Assembly Transmembrane Transport Endothelial Cell Development Response To Organic Substance System Development Movement Of Cell Or Subcellular Component Neuron Development Cell Differentiation Atrial Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication Multicellular Organismal Development Locomotion Cell Communication Single Organismal Cell-cell Adhesion Epithelial Cell Differentiation Cell Morphogenesis Axon Development Endothelial Cell Differentiation Neuron Differentiation Cell-cell Signaling Involved In Cardiac Conduction Cell Projection Organization Positive Regulation Of Rap GTPase Activity Neurological System Process Establishment Of Skin Barrier Adherens Junction Organization Skin Development Neuron Projection Morphogenesis Cell-cell Signaling
Tagcloud ?		alpha8 backcross cataract cib collaborative connexin50 cryba1 crybb2 crystallinbetaa3 crystallinbetab2 d11mit31 d3mit22 d5mit88 dnas eu gap hybrids interspecific juction lens lie lim2 locus maps mp19 mp70 ngfg positions synteny	abp androgen ar blots clonal clu constitutes fshr hampering immortalized immunocytochemistry inhbb investigations loose mediators microarrays posttranslational responsiveness rhox5 sc sertoli sox9 spermatogenesis spinlw1 st38c stabilization testosterone undergoes wt1
Tagcloud (Difference) ?		alpha8 backcross cataract cib collaborative connexin50 cryba1 crybb2 crystallinbetaa3 crystallinbetab2 d11mit31 d3mit22 d5mit88 dnas eu gap hybrids interspecific juction lens lie lim2 locus maps mp19 mp70 ngfg positions synteny	abp androgen ar blots clonal clu constitutes fshr hampering immortalized immunocytochemistry inhbb investigations loose mediators microarrays posttranslational responsiveness rhox5 sc sertoli sox9 spermatogenesis spinlw1 st38c stabilization testosterone undergoes wt1
Tagcloud (Intersection) ?