GJA8 and PROKR2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GJA8	PROKR2
Description		gap junction protein alpha 8	prokineticin receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction	Plasma Membrane Membrane
	Molecular Function	Gap Junction Channel Activity Protein Binding	G Protein-coupled Receptor Activity Neuropeptide Y Receptor Activity Protein Binding
	Biological Process	Lens Development In Camera-type Eye Cell Communication Cell-cell Signaling Camera-type Eye Development Transmembrane Transport Gap Junction-mediated Intercellular Transport	Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Circadian Rhythm Cellular Response To Hormone Stimulus
Pathways		Gap junction assembly	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs
Diseases			Hypogonadotropic hypogonadism; Kallmann syndrome (KAL)
GWAS		Retinopathy x type 2 diabetes interaction ( 32541925) Triglyceride levels ( 34074324)	Leukocyte telomere length ( 32109421)
Interacting Genes		125 interacting genes: ABL1 ACKR2 APOA2 APOD APOL3 AQP4 ARL6IP6 ATP6V0B C1GALT1 C2CD2L C3orf52 CCDC167 CCL4 CD53 CIAO2A CLDN19 CLDN4 CLEC1A CLN6 COX20 CTXN3 CXCL16 CYBC1 CYP4F2 DEFB121 DOLK ERMP1 FDFT1 FXYD6 GIMAP1 GIMAP5 GJB2 GPR108 GPR151 GPR61 GUCA2A IGFBP5 INSIG2 ITGAM KIR2DL3 LAPTM4B LAT LEPROTL1 LHFPL5 MAL MALL MARCHF2 MFSD11 MFSD6 MGST2 MIP MS4A13 NINJ2 ORMDL2 OTOP2 P2RY13 PGAP2 PLN PLP1 PMP22 PNLIPRP1 PRAF2 PROKR2 PTPRN QRFPR REEP6 RNF152 RUSF1 RXFP4 S1PR5 SCARF1 SEC22B SEC22C SEC23A SFTPC SLC13A2 SLC13A5 SLC16A12 SLC16A13 SLC16A3 SLC30A3 SLC35A4 SLC35F1 SLC35F6 SLC38A4 SLC38A7 SLC39A2 SLC39A7 SLC39A9 SLC52A1 SLC66A1 SLC66A2 SLC8A3 SMCO4 SMIM1 STX1B STX8 THSD7B TJP1 TMBIM6 TMEM100 TMEM107 TMEM121 TMEM128 TMEM147 TMEM182 TMEM239 TMEM242 TMEM243 TMEM42 TMEM45A TMEM60 TMEM65 TMEM72 TMEM86B TMEM97 TSPAN33 TWSG1 UBXN8 UNC93A UPK1B VAMP5 VAPB YIF1A YIPF6	5 interacting genes: ADIPOQ FNDC9 GJA8 IGFBP5 UBE2J1
Entrez ID		2703	128674
HPRD ID		02939	08453
Ensembl ID		ENSG00000121634	ENSG00000101292
Uniprot IDs		P48165 X5D7G1	A8K1T0 Q8NFJ6
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transport Organic Acid Transmembrane Transport Zinc Ion Transmembrane Transport Structural Constituent Of Myelin Sheath Zinc Ion Transport Transmembrane Transporter Activity Fumarate Transport Carboxylic Acid Transport Organic Acid Transport Sodium:dicarboxylate Symporter Activity Chemical Homeostasis Organic Anion Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Homeostatic Process Cholesterol Binding Metal Ion Transmembrane Transporter Activity Succinate Transmembrane Transporter Activity Succinate Transport Succinate Transmembrane Transport COPII-coated Vesicle Budding	Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Intracellular Protein Transport Regulation Of Smooth Muscle Cell Migration Cellular Response To CAMP Negative Regulation Of Smooth Muscle Cell Proliferation Response To CAMP Negative Regulation Of Skeletal Muscle Hypertrophy Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Metanephric Mesenchymal Cell Migration Positive Regulation Of Renal Albumin Absorption Positive Regulation Of Metanephric Podocyte Development Positive Regulation Of Glycogen (starch) Synthase Activity Negative Regulation Of Intracellular Transport Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Detection Of Oxidative Stress Negative Regulation Of Protein Transport Negative Regulation Of Establishment Of Protein Localization Response To Purine-containing Compound Regulation Of Intracellular Protein Transport Regulation Of Smooth Muscle Cell Proliferation Insulin-like Growth Factor Binding Protein Complex Response To Linoleic Acid Positive Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Cholesterol Import Insulin-like Growth Factor Ternary Complex Negative Regulation Of Protein Autophosphorylation Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Receptor Binding Regulation Of Glycogen (starch) Synthase Activity Carbohydrate Homeostasis Mammary Gland Involution Glucose Homeostasis Regulation Of Cholesterol Import Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of CAMP-dependent Protein Kinase Activity Negative Regulation Of Protein Localization Gap Junction-mediated Intercellular Transport Response To Sucrose Response To Disaccharide Hrd1p Ubiquitin Ligase Complex Insulin-like Growth Factor II Binding Negative Regulation Of Macrophage Differentiation Adiponectin-activated Signaling Pathway Regulation Of Intracellular Transport Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Intercellular Transport Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Protein Exit From Endoplasmic Reticulum
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