GJA8 and LHFPL5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GJA8	LHFPL5
Description		gap junction protein alpha 8	LHFPL tetraspan subfamily member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction	Plasma Membrane Membrane Apical Plasma Membrane Stereocilium Bundle Stereocilium Tip
	Molecular Function	Gap Junction Channel Activity Protein Binding	Protein Binding
	Biological Process	Lens Development In Camera-type Eye Cell Communication Cell-cell Signaling Camera-type Eye Development Transmembrane Transport Gap Junction-mediated Intercellular Transport	Monoatomic Ion Transport Sensory Perception Of Sound Detection Of Mechanical Stimulus Involved In Sensory Perception Of Sound Detection Of Mechanical Stimulus Involved In Sensory Perception Auditory Receptor Cell Stereocilium Organization
Pathways		Gap junction assembly	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Retinopathy x type 2 diabetes interaction ( 32541925) Triglyceride levels ( 34074324)	Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494)
Interacting Genes		125 interacting genes: ABL1 ACKR2 APOA2 APOD APOL3 AQP4 ARL6IP6 ATP6V0B C1GALT1 C2CD2L C3orf52 CCDC167 CCL4 CD53 CIAO2A CLDN19 CLDN4 CLEC1A CLN6 COX20 CTXN3 CXCL16 CYBC1 CYP4F2 DEFB121 DOLK ERMP1 FDFT1 FXYD6 GIMAP1 GIMAP5 GJB2 GPR108 GPR151 GPR61 GUCA2A IGFBP5 INSIG2 ITGAM KIR2DL3 LAPTM4B LAT LEPROTL1 LHFPL5 MAL MALL MARCHF2 MFSD11 MFSD6 MGST2 MIP MS4A13 NINJ2 ORMDL2 OTOP2 P2RY13 PGAP2 PLN PLP1 PMP22 PNLIPRP1 PRAF2 PROKR2 PTPRN QRFPR REEP6 RNF152 RUSF1 RXFP4 S1PR5 SCARF1 SEC22B SEC22C SEC23A SFTPC SLC13A2 SLC13A5 SLC16A12 SLC16A13 SLC16A3 SLC30A3 SLC35A4 SLC35F1 SLC35F6 SLC38A4 SLC38A7 SLC39A2 SLC39A7 SLC39A9 SLC52A1 SLC66A1 SLC66A2 SLC8A3 SMCO4 SMIM1 STX1B STX8 THSD7B TJP1 TMBIM6 TMEM100 TMEM107 TMEM121 TMEM128 TMEM147 TMEM182 TMEM239 TMEM242 TMEM243 TMEM42 TMEM45A TMEM60 TMEM65 TMEM72 TMEM86B TMEM97 TSPAN33 TWSG1 UBXN8 UNC93A UPK1B VAMP5 VAPB YIF1A YIPF6	131 interacting genes: ADGRG3 APOL3 AQP2 AQP6 AQP9 ARL13B BTN2A2 C14orf180 C1GALT1 C3orf52 C5orf46 CD37 CD53 CD72 CD79A CD81 CDS2 CERS4 CLCN7 CLDN22 CLDN5 CLDND2 CLEC14A CMTM7 CPLX4 CREB3 CREB3L1 CTXN3 CXCL16 CYB561 DAGLA ELOVL4 EMP1 EMP3 ENTPD3 ERG28 ERGIC3 FAM209A FCGR1A FFAR2 FNDC9 FXYD6 GJA8 GJB2 GJB3 GJB4 GJB6 GPR152 GPR37L1 GPR42 GPRC5D GPX8 HAS3 HLA-DQA2 HSD17B13 INSIG2 ITGB2 JAGN1 KASH5 KCNK5 KIR2DL3 KTN1 LAT LIME1 LMNA LNPEP LPAR3 LRRC25 LRRC4C MFF MIP MS4A13 MTIF3 NINJ2 NIPAL4 NKG7 NRG4 PDZK1IP1 PLLP PLP1 PLP2 RMDN3 RPRM RUSF1 SAR1A SCN3B SEC22A SEC22B SERP1 SERP2 SERTM1 SLC16A2 SLC34A2 SLC35A1 SLC35B4 SLC35H1 SLC41A1 SLC61A1 SMIM1 SSMEM1 SYNJ2BP TEX264 TFRC TIMMDC1 TM4SF18 TM4SF4 TMEM100 TMEM107 TMEM128 TMEM201 TMEM218 TMEM229B TMEM248 TMEM254 TMEM31 TMEM42 TMEM50B TMEM52B TMEM60 TMEM86A TMEM97 TMX1 TMX2 TRARG1 TSPAN33 TSPAN7 TSPO UBIAD1 VAMP3 VMA21 ZDHHC15
Entrez ID		2703	222662
HPRD ID		02939	13989
Ensembl ID		ENSG00000121634	ENSG00000197753
Uniprot IDs		P48165 X5D7G1	Q8TAF8
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transport Organic Acid Transmembrane Transport Zinc Ion Transmembrane Transport Structural Constituent Of Myelin Sheath Zinc Ion Transport Transmembrane Transporter Activity Fumarate Transport Carboxylic Acid Transport Organic Acid Transport Sodium:dicarboxylate Symporter Activity Chemical Homeostasis Organic Anion Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Homeostatic Process Cholesterol Binding Metal Ion Transmembrane Transporter Activity Succinate Transmembrane Transporter Activity Succinate Transport Succinate Transmembrane Transport COPII-coated Vesicle Budding	Membrane Protein Binding Plasma Membrane Gap Junction-mediated Intercellular Transport Intercellular Transport Connexin Complex Endoplasmic Reticulum Membrane Endoplasmic Reticulum Gap Junction Channel Activity Gap Junction Water Channel Activity Water Transport Bleb Assembly Pyrimidine Nucleotide-sugar Transmembrane Transport Nucleotide-sugar Transmembrane Transport Transmembrane Transport Fluid Transport Channel Activity B Cell Receptor Complex Gap Junction Channel Activity Involved In Cell Communication By Electrical Coupling Immunological Synapse
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