GJA8 and SLC16A12

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GJA8	SLC16A12
Description		gap junction protein alpha 8	solute carrier family 16 member 12
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction	Plasma Membrane Membrane Basolateral Plasma Membrane
	Molecular Function	Gap Junction Channel Activity Protein Binding	Creatine Transmembrane Transporter Activity Protein Binding Uniporter Activity Transmembrane Transporter Activity
	Biological Process	Lens Development In Camera-type Eye Cell Communication Cell-cell Signaling Camera-type Eye Development Transmembrane Transport Gap Junction-mediated Intercellular Transport	Creatine Transmembrane Transport Creatinine Metabolic Process Transmembrane Transport Transport Across Blood-brain Barrier
Pathways		Gap junction assembly
Drugs
Diseases
GWAS		Retinopathy x type 2 diabetes interaction ( 32541925) Triglyceride levels ( 34074324)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		125 interacting genes: ABL1 ACKR2 APOA2 APOD APOL3 AQP4 ARL6IP6 ATP6V0B C1GALT1 C2CD2L C3orf52 CCDC167 CCL4 CD53 CIAO2A CLDN19 CLDN4 CLEC1A CLN6 COX20 CTXN3 CXCL16 CYBC1 CYP4F2 DEFB121 DOLK ERMP1 FDFT1 FXYD6 GIMAP1 GIMAP5 GJB2 GPR108 GPR151 GPR61 GUCA2A IGFBP5 INSIG2 ITGAM KIR2DL3 LAPTM4B LAT LEPROTL1 LHFPL5 MAL MALL MARCHF2 MFSD11 MFSD6 MGST2 MIP MS4A13 NINJ2 ORMDL2 OTOP2 P2RY13 PGAP2 PLN PLP1 PMP22 PNLIPRP1 PRAF2 PROKR2 PTPRN QRFPR REEP6 RNF152 RUSF1 RXFP4 S1PR5 SCARF1 SEC22B SEC22C SEC23A SFTPC SLC13A2 SLC13A5 SLC16A12 SLC16A13 SLC16A3 SLC30A3 SLC35A4 SLC35F1 SLC35F6 SLC38A4 SLC38A7 SLC39A2 SLC39A7 SLC39A9 SLC52A1 SLC66A1 SLC66A2 SLC8A3 SMCO4 SMIM1 STX1B STX8 THSD7B TJP1 TMBIM6 TMEM100 TMEM107 TMEM121 TMEM128 TMEM147 TMEM182 TMEM239 TMEM242 TMEM243 TMEM42 TMEM45A TMEM60 TMEM65 TMEM72 TMEM86B TMEM97 TSPAN33 TWSG1 UBXN8 UNC93A UPK1B VAMP5 VAPB YIF1A YIPF6	4 interacting genes: AQP6 CD79A FXYD3 GJA8
Entrez ID		2703	387700
HPRD ID		02939	17365
Ensembl ID		ENSG00000121634	ENSG00000152779
Uniprot IDs		P48165 X5D7G1	Q6ZSM3
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transport Organic Acid Transmembrane Transport Zinc Ion Transmembrane Transport Structural Constituent Of Myelin Sheath Zinc Ion Transport Transmembrane Transporter Activity Fumarate Transport Carboxylic Acid Transport Organic Acid Transport Sodium:dicarboxylate Symporter Activity Chemical Homeostasis Organic Anion Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Homeostatic Process Cholesterol Binding Metal Ion Transmembrane Transporter Activity Succinate Transmembrane Transporter Activity Succinate Transport Succinate Transmembrane Transport COPII-coated Vesicle Budding	PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Chloride Transmembrane Transport Monoatomic Anion Transmembrane Transport Inorganic Anion Transmembrane Transport Inorganic Anion Transport Monoatomic Anion Transport Chloride Transport IgM B Cell Receptor Complex Carbon Dioxide Transmembrane Transporter Activity Transmembrane Transport Carbon Dioxide Transmembrane Transport B Cell Receptor Complex Gap Junction-mediated Intercellular Transport Monoatomic Anion Channel Activity Renal Water Transport Positive Regulation Of Sodium Ion Export Across Plasma Membrane Ion Channel Regulator Activity Ammonium Channel Activity Ammonium Transmembrane Transport Intercellular Transport Water Channel Activity Carbon Dioxide Transport Positive Regulation Of Sodium Ion Transmembrane Transport Connexin Complex Gap Junction Channel Activity One-carbon Compound Transport Water Transport Gap Junction Positive Regulation Of Sodium Ion Transport Sodium Channel Regulator Activity Fluid Transport Inorganic Ion Transmembrane Transport Channel Activity B Cell Proliferation Regulation Of Sodium Ion Transmembrane Transport Lens Development In Camera-type Eye Monoatomic Ion Transmembrane Transport Multivesicular Body B Cell Receptor Signaling Pathway Monoatomic Ion Transport Chloride Channel Activity Regulation Of Sodium Ion Transport
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