GJA8 and MIP

Number of citations of the paper that reports this interaction (PMID 9664032)
7

Data Source:
HPRD (in vivo)

		GJA8	MIP
Gene Name		gap junction protein, alpha 8, 50kDa	major intrinsic protein of lens fiber
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Integral Component Of Plasma Membrane Connexon Complex	Plasma Membrane Integral Component Of Plasma Membrane Gap Junction Apical Plasma Membrane Intracellular Membrane-bounded Organelle Intracellular Canaliculus
	Molecular Function	Gap Junction Channel Activity Channel Activity	Structural Constituent Of Eye Lens Transporter Activity Calmodulin Binding Water Channel Activity Glycerol Channel Activity
	Biological Process	Lens Development In Camera-type Eye Transport Cell-cell Signaling Visual Perception Protein Homooligomerization Transmembrane Transport	Lens Development In Camera-type Eye Water Transport Visual Perception Cellular Water Homeostasis Canalicular Bile Acid Transport Glycerol Transport Ion Transmembrane Transport Response To Stimulus Transmembrane Transport
Pathways		Gap junction assembly Gap junction trafficking and regulation Gap junction trafficking	Passive transport by Aquaporins Aquaporin-mediated transport
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: MIP TJP1	9 interactors: CALM1 CRYAA CRYAB CRYBB2 CRYGC FOXA2 GJA3 GJA8 PRKACA
Entrez ID		2703	4284
HPRD ID		02939	01098
Ensembl ID		ENSG00000121634	ENSG00000135517
Uniprot IDs		P48165	P30301
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Involved In Cell-cell Junction Organization Response To Magnetism Canalicular Bile Acid Transport Cellular Chemical Homeostasis Protein Processing Involved In Protein Targeting To Mitochondrion Establishment Of Endothelial Intestinal Barrier Bile Acid Secretion Glycerol Transport Cellular Homeostasis Polyol Transport Mitochondrial Protein Processing Negative Regulation Of Vascular Permeability Cellular Water Homeostasis Sensory Perception Chemical Homeostasis Establishment Of Endothelial Barrier Hippo Signaling Neurological System Process Bile Acid And Bile Salt Transport Cell Volume Homeostasis Regulation Of Vascular Permeability Blastocyst Formation Homeostatic Process Water Transport Endothelial Cell Development Fluid Transport Carbohydrate Transmembrane Transport Acid Secretion Cellular Response To Glucose Stimulus Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Water Homeostasis Protein Targeting To Mitochondrion Protein Localization To Mitochondrion Execution Phase Of Apoptosis Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Endothelial Cell Differentiation Endothelium Development Lens Development In Camera-type Eye Blastocyst Development Cell-cell Junction Assembly Carbohydrate Transport Response To Glucose Monocarboxylic Acid Transport Response To Ethanol Mitochondrial Transport Sensory Perception Of Sound Visual Perception Sensory Perception Of Light Stimulus Sensory Perception Of Mechanical Stimulus	Visual Perception Sensory Perception Of Light Stimulus Sensory Perception Camera-type Eye Development Negative Regulation Of Transport Eye Development Regulation Of Intracellular Transport Organ Development Cellular Response To Radiation Regulation Of Cellular Localization Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Neurological System Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Rhodopsin Mediated Signaling Pathway Sensory Organ Development Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Activation Of Adenylate Cyclase Activity Rhodopsin Mediated Signaling Pathway Positive Regulation Of Adenylate Cyclase Activity Protein Homooligomerization Positive Regulation Of Lyase Activity System Development Activation Of Phospholipase C Activity Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of CAMP Biosynthetic Process Cell-cell Signaling Regulation Of Cyclase Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of CAMP Metabolic Process Multicellular Organismal Development Positive Regulation Of Phospholipase Activity Regulation Of Heart Rate Negative Regulation Of Phosphorylation Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Phototransduction, Visible Light Anatomical Structure Development Negative Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Positive Regulation Of Dense Core Granule Biogenesis Negative Regulation Of Detection Of Glucose Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of Phospholipase Activity Protein Oligomerization Regulation Of Striated Muscle Contraction Regulation Of CAMP Biosynthetic Process
Tagcloud ?		alpha8 backcross cataract cib collaborative connexin50 cryba1 crybb2 crystallinbetaa3 crystallinbetab2 d11mit31 d3mit22 d5mit88 dnas eu gap hybrids interspecific juction lens lie lim2 locus maps mp19 mp70 ngfg positions synteny	7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Difference) ?		alpha8 backcross cataract cib collaborative connexin50 cryba1 crybb2 crystallinbetaa3 crystallinbetab2 d11mit31 d3mit22 d5mit88 dnas eu gap hybrids interspecific juction lens lie lim2 locus maps mp19 mp70 ngfg positions synteny	7b11 aminoxypentane augmented broadening ccr1 ccr2 ccr3 ccr5 chemokine chemokines chemotactic cxc cxcr1 eotaxin hcc2 leukocytes mcp migrate migrated monocyte orienting pmn polymorphonuclear prototypic rantes reorients speculate th1 th2
Tagcloud (Intersection) ?