GJA8 and SLC8A3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GJA8	SLC8A3
Description		gap junction protein alpha 8	solute carrier family 8 member A3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Gap Junction Connexin Complex Membrane Anchoring Junction	Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Centrosome Cytosol Microtubule Plasma Membrane Postsynaptic Density Microtubule Cytoskeleton Membrane Sarcoplasm Axon Dendrite Neuromuscular Junction Sarcolemma Cell Projection Neuronal Cell Body Dendritic Spine Perikaryon Axon Terminus Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Anchoring Junction Postsynapse
	Molecular Function	Gap Junction Channel Activity Protein Binding	Calcium:sodium Antiporter Activity Protein Binding Calmodulin Binding Antiporter Activity Calcium:monoatomic Cation Antiporter Activity Metal Ion Binding Calcium:monoatomic Cation Antiporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Lens Development In Camera-type Eye Cell Communication Cell-cell Signaling Camera-type Eye Development Transmembrane Transport Gap Junction-mediated Intercellular Transport	Hematopoietic Progenitor Cell Differentiation Monoatomic Ion Transport Sodium Ion Transport Calcium Ion Transport Mitochondrial Calcium Ion Transmembrane Transport Intracellular Calcium Ion Homeostasis Cell Communication Learning Or Memory Learning Memory Regulation Of Skeletal Muscle Contraction Telencephalon Development Metal Ion Transport Sodium Ion Transmembrane Transport Myelination Oligodendrocyte Differentiation Synapse Organization Mitochondrial Calcium Ion Homeostasis Transmembrane Transport Long-term Synaptic Potentiation Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport Cellular Response To CAMP Cellular Response To Hypoxia Calcium Ion Import Across Plasma Membrane Modulation Of Excitatory Postsynaptic Potential Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Negative Regulation Of Intracellular Signal Transduction Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane
Pathways		Gap junction assembly	Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis Mitochondrial calcium ion transport
Drugs
Diseases
GWAS		Retinopathy x type 2 diabetes interaction ( 32541925) Triglyceride levels ( 34074324)	Bipolar disorder ( 31043756) Corneal curvature ( 22969067) Cystic fibrosis severity ( 21602797) Daytime sleep phenotypes ( 27126917) Metabolite levels ( 23823483)
Interacting Genes		125 interacting genes: ABL1 ACKR2 APOA2 APOD APOL3 AQP4 ARL6IP6 ATP6V0B C1GALT1 C2CD2L C3orf52 CCDC167 CCL4 CD53 CIAO2A CLDN19 CLDN4 CLEC1A CLN6 COX20 CTXN3 CXCL16 CYBC1 CYP4F2 DEFB121 DOLK ERMP1 FDFT1 FXYD6 GIMAP1 GIMAP5 GJB2 GPR108 GPR151 GPR61 GUCA2A IGFBP5 INSIG2 ITGAM KIR2DL3 LAPTM4B LAT LEPROTL1 LHFPL5 MAL MALL MARCHF2 MFSD11 MFSD6 MGST2 MIP MS4A13 NINJ2 ORMDL2 OTOP2 P2RY13 PGAP2 PLN PLP1 PMP22 PNLIPRP1 PRAF2 PROKR2 PTPRN QRFPR REEP6 RNF152 RUSF1 RXFP4 S1PR5 SCARF1 SEC22B SEC22C SEC23A SFTPC SLC13A2 SLC13A5 SLC16A12 SLC16A13 SLC16A3 SLC30A3 SLC35A4 SLC35F1 SLC35F6 SLC38A4 SLC38A7 SLC39A2 SLC39A7 SLC39A9 SLC52A1 SLC66A1 SLC66A2 SLC8A3 SMCO4 SMIM1 STX1B STX8 THSD7B TJP1 TMBIM6 TMEM100 TMEM107 TMEM121 TMEM128 TMEM147 TMEM182 TMEM239 TMEM242 TMEM243 TMEM42 TMEM45A TMEM60 TMEM65 TMEM72 TMEM86B TMEM97 TSPAN33 TWSG1 UBXN8 UNC93A UPK1B VAMP5 VAPB YIF1A YIPF6	5 interacting genes: GJA8 PPP3CB YWHAB YWHAE YWHAQ
Entrez ID		2703	6547
HPRD ID		02939	09723
Ensembl ID		ENSG00000121634	ENSG00000100678
Uniprot IDs		P48165 X5D7G1	B3KU59 P57103
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Protein Binding Plasma Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Transmembrane Transport Zinc Ion Transmembrane Transporter Activity Carboxylic Acid Transmembrane Transport Organic Acid Transmembrane Transport Zinc Ion Transmembrane Transport Structural Constituent Of Myelin Sheath Zinc Ion Transport Transmembrane Transporter Activity Fumarate Transport Carboxylic Acid Transport Organic Acid Transport Sodium:dicarboxylate Symporter Activity Chemical Homeostasis Organic Anion Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Homeostatic Process Cholesterol Binding Metal Ion Transmembrane Transporter Activity Succinate Transmembrane Transporter Activity Succinate Transport Succinate Transmembrane Transport COPII-coated Vesicle Budding	Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Transport Negative Regulation Of Monoatomic Ion Transport Phosphoserine Residue Binding Negative Regulation Of Transmembrane Transport Protein Targeting Protein Domain Specific Binding Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Calcium Ion Transmembrane Transport Phosphoprotein Binding Protein Phosphatase Inhibitor Activity Protein Sequestering Activity Substantia Nigra Development Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Calcium Ion Transport Enzyme Binding Regulation Of Monoatomic Ion Transport Neural Nucleus Development Focal Adhesion Regulation Of Protein Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Establishment Of Protein Localization Regulation Of Cellular Localization Regulation Of Transport Melanosome Regulation Of Nucleocytoplasmic Transport Histone Deacetylase Binding Regulation Of Heart Rate By Hormone Transmembrane Transporter Binding Regulation Of Calcium Ion Transmembrane Transport Regulation Of Intracellular Protein Transport Regulation Of Protein Localization To Nucleus Positive Regulation Of Lysosome Organization Intracellular Signaling Cassette Calmodulin-dependent Protein Phosphatase Activity Regulation Of Protein Localization Regulation Of Heart Rate By Chemical Signal Negative Regulation Of Calcium Ion Export Across Plasma Membrane Negative Regulation Of Protein Localization Gap Junction-mediated Intercellular Transport Negative Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Calcium Ion Transport Calcineurin Complex Regulation Of Calcium Ion Export Across Plasma Membrane Locomotion Involved In Locomotory Behavior Positive Regulation Of Protein Transport Positive Regulation Of Toll-like Receptor Signaling Pathway Protein Phosphatase 2B Binding Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Intracellular Transport
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