CBLC and BIRC2

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		CBLC	BIRC2
Gene Name		Cbl proto-oncogene C, E3 ubiquitin protein ligase	baculoviral IAP repeat containing 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Extracellular Vesicular Exosome	XY Body Nucleus Cytoplasm Cytosol Spindle Microtubule Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft
	Molecular Function	Phosphotyrosine Binding Signal Transducer Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Zinc Ion Binding Ligase Activity SH3 Domain Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein N-terminus Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity	Protein Polyubiquitination Response To Hypoxia Placenta Development Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription, DNA-templated Regulation Of Transcription, DNA-templated Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Cell Surface Receptor Signaling Pathway Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway NIK/NF-kappaB Signaling Regulation Of RIG-I Signaling Pathway Regulation Of Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Regulation Of Innate Immune Response Response To Ethanol Regulation Of Cell Differentiation Regulation Of Inflammatory Response Protein Heterooligomerization Response To CAMP Regulation Of Cell Cycle Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Necroptotic Process Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Mitotic Spindle Assembly Negative Regulation Of Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Protein K48-linked Ubiquitination Positive Regulation Of Protein Monoubiquitination Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Reactive Oxygen Species Metabolic Process
Pathways			Apoptotic cleavage of cellular proteins IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling Apoptotic execution phase MyD88-independent cascade Activated TLR4 signalling Toll-Like Receptors Cascades Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways NOD1/2 Signaling Pathway Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Programmed Cell Death Innate Immune System
Drugs
Diseases
GWAS			Prostate cancer ( 23535732)
Protein-Protein Interactions		33 interactors: BIRC2 CHFR CKM CRK EGFR FYN GRB2 ITCH LYN NACAD OTUD6A OXA1L SH3GL3 SHC1 SPRY2 SRC TGFB1I1 TRAF4 TRIM46 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2I UBE2K UBE2L3 UBE2L6 UBE2R2 USP2 USP21 ZAP70	58 interactors: BIRC5 BIRC7 BOLA1 CASP2 CASP3 CASP7 CASP9 CBLC CD40 DIABLO DZIP3 EAF2 EXOSC5 FBXO7 GAS1 GCC1 GFAP GSPT1 HSP90B1 HTRA2 IKBKE IKBKG JUP LTBR MAGEA11 MAP3K2 MAP3K3 NMB OTUB1 PACS2 PCSK9 PPM1K RAC1 RAF1 RHOA RIPK1 RIPK2 RIPK3 RIPK4 RNF181 TRADD TRAF1 TRAF2 TRIM34 TSG101 TSGA10 UBB UBC UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2J1 UBE2Q2 UBE2S UBE2V1 UBE2W WDYHV1
Entrez ID		23624	329
HPRD ID		09765	03419
Ensembl ID		ENSG00000142273	ENSG00000110330
Uniprot IDs		Q9ULV8	Q13490
PDB IDs		3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR	1QBH 2L9M 3D9T 3D9U 3M1D 3MUP 3OZ1 3T6P 3UW4 4EB9 4HY4 4HY5 4LGE 4LGU
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Immune Response-regulating Signaling Pathway Cellular Macromolecule Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Innate Immune Response Protein K48-linked Ubiquitination Cellular Protein Modification Process Proteolysis Regulation Of Immune Response Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Defense Response Proteasomal Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Catabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Protein Metabolic Process Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Abiotic Stimulus Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Neurotrophin Signaling Pathway Pattern Recognition Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction	Programmed Cell Death Cell Death Death Apoptotic Process Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Activation Of Innate Immune Response Regulation Of Protein Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Immune Response-regulating Signaling Pathway Positive Regulation Of Innate Immune Response Protein Ubiquitination Cellular Response To Stress Regulation Of Cell Death Protein Modification By Small Protein Conjugation Positive Regulation Of Cellular Protein Metabolic Process Protein Polyubiquitination Protein Processing Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Innate Immune Response Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Signal Transduction Protein Metabolic Process Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cell Death Protein Catabolic Process Cellular Macromolecule Catabolic Process Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Transferase Activity Response To Stress Cellular Protein Catabolic Process Cellular Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Cellular Protein Metabolic Process
Tagcloud ?		adenosylcobalamin autosomal az0348 cobalamin congenital consequently convert create distortion embryos giant gt heterozygous homocysteine homozygous inherited insertion intron matings methylcobalamin methylmalonic midgestation mmachc modeled outgrowth recessive requirement unable wtsi	2b arrest baculoviral c4 caspases cdk2 ciap1 consumer deacetylases dependently du ester hdacs immortalized lncap maa malformation methoxyacetic named p63 p73 pharmaceutical phthalates prns prostatic rwpe spermatocyte suppresses turning
Tagcloud (Difference) ?		adenosylcobalamin autosomal az0348 cobalamin congenital consequently convert create distortion embryos giant gt heterozygous homocysteine homozygous inherited insertion intron matings methylcobalamin methylmalonic midgestation mmachc modeled outgrowth recessive requirement unable wtsi	2b arrest baculoviral c4 caspases cdk2 ciap1 consumer deacetylases dependently du ester hdacs immortalized lncap maa malformation methoxyacetic named p63 p73 pharmaceutical phthalates prns prostatic rwpe spermatocyte suppresses turning
Tagcloud (Intersection) ?