CBLC and NACAD

Number of citations of the paper that reports this interaction (PubMedID 21900206)
0

Data Source:
BioGRID (two hybrid)

		CBLC	NACAD
Description		Cbl proto-oncogene C	NAC alpha domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Raft	Nucleus Cytoplasm Nascent Polypeptide-associated Complex
	Molecular Function	Phosphotyrosine Residue Binding Ubiquitin-protein Transferase Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Transferase Activity SH3 Domain Binding Receptor Tyrosine Kinase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Unfolded Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Protein Ubiquitination Regulation Of Signaling Protein Catabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Protein Stabilization Response To Glial Cell Derived Neurotrophic Factor	Protein Targeting To Membrane Protein Transport
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 24507774) Weight ( 28552196)	Eosinophil count ( 32888494)
Interacting Genes		55 interacting genes: AKT1 BAP1 BIRC2 CCND2 CDK6 CDKN2B CHFR CKM CRK EGFR EPHA2 ERBB2 FGFR4 FYN GLIS2 GRB2 ITCH LATS2 LYN MAP2K3 MDM4 MYC NACAD NF2 NFIC NSD3 OTUD6A OXA1L RAF1 SH3GL3 SHC1 SNCA SPRY2 SRC STK11 TERT TGFB1I1 TP53 TRAF4 TRIM46 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2I UBE2K UBE2L3 UBE2L6 UBE2R2 USP2 USP21 YES1 ZAP70	10 interacting genes: AGTR1 CBLC HDAC6 MAP4K2 NR4A1 PTK2 RPS27 STAT3 TNNT1 YAE1
Entrez ID		23624	23148
HPRD ID		09765
Ensembl ID		ENSG00000142273	ENSG00000136274
Uniprot IDs		Q9ULV8	O15069
PDB IDs		3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR
Enriched GO Terms of Interacting Partners?		Transferase Activity Protein Modification Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Ubiquitin Conjugating Enzyme Activity Protein Metabolic Process Regulation Of Signal Transduction Proteolysis Regulation Of Protein Modification Process ATP Binding Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Protein Tyrosine Kinase Activity Regulation Of MAPK Cascade Nucleotide Binding Response To Growth Factor Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Ubiquitin-protein Transferase Activity Positive Regulation Of Protein Metabolic Process Protein Kinase Activity Cell Surface Receptor Signaling Pathway Kinase Activity Cytosol Regulation Of Protein Metabolic Process Protein Polyubiquitination Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Regulation Of Protein Localization Macromolecule Catabolic Process Positive Regulation Of Phosphate Metabolic Process Protein Modification By Small Protein Conjugation Ephrin Receptor Binding Positive Regulation Of Phosphorylation Protein Ubiquitination Nucleus Cellular Response To Growth Factor Stimulus Intracellular Signal Transduction Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Primary Metabolic Process	Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Endothelial Cell Proliferation Nuclear Glucocorticoid Receptor Binding Regulation Of Epithelial Cell Proliferation Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Cell Population Proliferation Regulation Of Endothelial Cell Proliferation Growth Hormone Receptor Signaling Pathway Negative Regulation Of Reactive Oxygen Species Metabolic Process Angiotensin Type I Receptor Activity Protein-containing Complex Organization Bradykinin Receptor Binding Positive Regulation Of Cell Differentiation Macromolecule Metabolic Process Establishment Of Protein Localization To Organelle Nuclear Receptor Activity Cellular Response To Hormone Stimulus Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Epithelial Cell Migration ERBB Signaling Pathway Regulation Of Epithelial Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Slow-twitch Skeletal Muscle Fiber Contraction Positive Regulation Of Cellular Response To Oxidative Stress Acetylspermidine Deacetylase Activity Polyamine Deacetylation Spermidine Deacetylation Peroxidase Inhibitor Activity Negative Regulation Of Aggrephagy Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation Tubulin Deacetylase Activity Phosphorylation Protein Phosphatase Binding Regulation Of Cell Population Proliferation Phospholipase C-activating Angiotensin-activated Signaling Pathway Renin-angiotensin Regulation Of Aldosterone Production Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Autophagy Negative Regulation Of Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Skeletal Muscle Cell Proliferation Tubulin Deacetylation Positive Regulation Of Response To Oxidative Stress Regulation Of Cholangiocyte Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Angiotensin Type II Receptor Activity
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