CBLC and CHFR

Number of citations of the paper that reports this interaction (PMID 22493164)
2

Data Source:
BioGRID (two hybrid)

		CBLC	CHFR
Gene Name		Cbl proto-oncogene C, E3 ubiquitin protein ligase	checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations	Cellular Component	Nucleus Extracellular Vesicular Exosome	Nucleus PML Body
	Molecular Function	Phosphotyrosine Binding Signal Transducer Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Zinc Ion Binding Ligase Activity SH3 Domain Binding Ubiquitin Protein Ligase Activity	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Mitotic Nuclear Division Mitotic Cell Cycle Checkpoint Modification-dependent Protein Catabolic Process Cell Division
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		33 interactors: BIRC2 CHFR CKM CRK EGFR FYN GRB2 ITCH LYN NACAD OTUD6A OXA1L SH3GL3 SHC1 SPRY2 SRC TGFB1I1 TRAF4 TRIM46 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2I UBE2K UBE2L3 UBE2L6 UBE2R2 USP2 USP21 ZAP70	26 interactors: AURKA BRD4 CBLC EEF1G GABBR1 HDAC1 HDAC2 HIST2H2AC HIST2H2BE ITGAE PML RNF125 RNF7 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N UBE2V1 UBE2W WDR47
Entrez ID		23624	55743
HPRD ID		09765	05552
Ensembl ID		ENSG00000142273	ENSG00000072609
Uniprot IDs		Q9ULV8	Q96EP1
PDB IDs		3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR	1LGP 1LGQ 2XOC 2XOY 2XOZ 2XP0
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Immune Response-regulating Signaling Pathway Cellular Macromolecule Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Innate Immune Response Protein K48-linked Ubiquitination Cellular Protein Modification Process Proteolysis Regulation Of Immune Response Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Defense Response Proteasomal Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Catabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Protein Metabolic Process Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Abiotic Stimulus Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Neurotrophin Signaling Pathway Pattern Recognition Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction	Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Metabolic Process Protein Catabolic Process Protein K11-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein K63-linked Ubiquitination Cellular Macromolecule Catabolic Process Protein Metabolic Process Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Cellular Response To Stress Proteolysis Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Cell Cycle Activation Of Innate Immune Response Catabolic Process Innate Immune Response Positive Regulation Of Innate Immune Response Histone Modification Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Innate Immune Response Chromatin Organization Mitotic Cell Cycle Regulation Of Cell Cycle Process Regulation Of Response To DNA Damage Stimulus Protein Monoubiquitination Positive Regulation Of Proteolysis Transforming Growth Factor Beta Receptor Signaling Pathway ISG15-protein Conjugation Cellular Response To DNA Damage Stimulus Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Fungiform Papilla Formation Regulation Of DNA-templated Transcription In Response To Stress Chromatin Modification Regulation Of Organelle Organization
Tagcloud ?		adenosylcobalamin autosomal az0348 cobalamin congenital consequently convert create distortion embryos giant gt heterozygous homocysteine homozygous inherited insertion intron matings methylcobalamin methylmalonic midgestation mmachc modeled outgrowth recessive requirement unable wtsi	adeno adenocarcinoma adenocarcinomas alk atlas biomarker correlates datasets egfr erbb2 exon19 fgfr1 fgfr2 fgfr3 kras nf1 pik3ca powerful predictor project ret ros1 seq squamous stk11 taxane tcga tp53 utilized
Tagcloud (Difference) ?		adenosylcobalamin autosomal az0348 cobalamin congenital consequently convert create distortion embryos giant gt heterozygous homocysteine homozygous inherited insertion intron matings methylcobalamin methylmalonic midgestation mmachc modeled outgrowth recessive requirement unable wtsi	adeno adenocarcinoma adenocarcinomas alk atlas biomarker correlates datasets egfr erbb2 exon19 fgfr1 fgfr2 fgfr3 kras nf1 pik3ca powerful predictor project ret ros1 seq squamous stk11 taxane tcga tp53 utilized
Tagcloud (Intersection) ?