CBLC and CKM

Number of citations of the paper that reports this interaction (PMID 20525694)
9

Data Source:
BioGRID (enzymatic study)

		CBLC	CKM
Gene Name		Cbl proto-oncogene C, E3 ubiquitin protein ligase	creatine kinase, muscle
Image
Gene Ontology Annotations	Cellular Component	Nucleus Extracellular Vesicular Exosome	Cytosol
	Molecular Function	Phosphotyrosine Binding Signal Transducer Activity Epidermal Growth Factor Receptor Binding Calcium Ion Binding Zinc Ion Binding Ligase Activity SH3 Domain Binding Ubiquitin Protein Ligase Activity	Creatine Kinase Activity ATP Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of MAP Kinase Activity	Creatine Metabolic Process Phosphorylation Cellular Nitrogen Compound Metabolic Process Small Molecule Metabolic Process Phosphocreatine Biosynthetic Process
Pathways			Metabolism of amino acids and derivatives Creatine metabolism
Drugs			Creatine (Diaminomethyl-Methyl-Amino)-Acetic Acid Adenosine-5\'-Diphosphate D-Arginine
Diseases
GWAS
Protein-Protein Interactions		33 interactors: BIRC2 CHFR CKM CRK EGFR FYN GRB2 ITCH LYN NACAD OTUD6A OXA1L SH3GL3 SHC1 SPRY2 SRC TGFB1I1 TRAF4 TRIM46 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2I UBE2K UBE2L3 UBE2L6 UBE2R2 USP2 USP21 ZAP70	10 interactors: ASB9 CBLC CKB FHL2 MYOC MYOM2 TRIM54 TRIM55 TRIM63 YWHAQ
Entrez ID		23624	1158
HPRD ID		09765	00426
Ensembl ID		ENSG00000142273	ENSG00000104879
Uniprot IDs		Q9ULV8	B2R892 P06732
PDB IDs		3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR	1I0E
Enriched GO Terms of Interacting Partners?		Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Polyubiquitination Immune Response-regulating Signaling Pathway Cellular Macromolecule Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Innate Immune Response Protein K48-linked Ubiquitination Cellular Protein Modification Process Proteolysis Regulation Of Immune Response Cellular Protein Metabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Immune Response Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Defense Response Proteasomal Protein Catabolic Process Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Transferase Activity Catabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Protein Metabolic Process Positive Regulation Of Immune System Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Fc Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Protein Metabolic Process Response To Growth Factor Regulation Of MAPK Cascade Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Abiotic Stimulus Regulation Of Cellular Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Intracellular Signal Transduction Neurotrophin Signaling Pathway Pattern Recognition Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction	Skeletal Muscle Adaptation Substantia Nigra Development Muscle System Process Signal Transduction Neural Nucleus Development Signaling Cell Communication ERBB2-ERBB3 Signaling Pathway Skeletal Muscle Hypertrophy Midbrain Development ERBB2 Signaling Pathway Cellular Response To Stimulus Atrial Cardiac Muscle Cell Development Protein Ubiquitination Osteoblast Differentiation Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Modification By Small Protein Conjugation Negative Regulation Of Cytoskeleton Organization Non-canonical Wnt Signaling Pathway Via JNK Cascade Skeletal Muscle Atrophy Cellular Chloride Ion Homeostasis Non-canonical Wnt Signaling Pathway Via MAPK Cascade Striated Muscle Atrophy Muscle Atrophy Clustering Of Voltage-gated Sodium Channels Chloride Ion Homeostasis Muscle Contraction Response To Stimulus Creatine Metabolic Process Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Neuronal Ion Channel Clustering Regulation Of Organelle Organization Negative Regulation Of Actin Filament Bundle Assembly Ossification Heart Trabecula Formation
Tagcloud ?		adenosylcobalamin autosomal az0348 cobalamin congenital consequently convert create distortion embryos giant gt heterozygous homocysteine homozygous inherited insertion intron matings methylcobalamin methylmalonic midgestation mmachc modeled outgrowth recessive requirement unable wtsi	auto cd cdai ckms colitis crohn diphthamide gangliosides gm3 ibd ibds immunomodulating immunomodulation implicate kp kynurenine metabolites metabolome metabolomics nineteen picolinic plasmas q qa quinolinic th17 uc ulcerative untargeted
Tagcloud (Difference) ?		adenosylcobalamin autosomal az0348 cobalamin congenital consequently convert create distortion embryos giant gt heterozygous homocysteine homozygous inherited insertion intron matings methylcobalamin methylmalonic midgestation mmachc modeled outgrowth recessive requirement unable wtsi	auto cd cdai ckms colitis crohn diphthamide gangliosides gm3 ibd ibds immunomodulating immunomodulation implicate kp kynurenine metabolites metabolome metabolomics nineteen picolinic plasmas q qa quinolinic th17 uc ulcerative untargeted
Tagcloud (Intersection) ?