ABL2 and SIVA1

Number of citations of the paper that reports this interaction (PubMedID 11278261)
0

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vitro)

		ABL2	SIVA1
Description		ABL proto-oncogene 2, non-receptor tyrosine kinase	SIVA1 apoptosis inducing factor
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Mitochondrion
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Phosphotyrosine Residue Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Kinase Activity Transferase Activity Enzyme Binding Manganese Ion Binding Metal Ion Binding Actin Filament Binding	Virus Receptor Activity Tumor Necrosis Factor Receptor Binding CD27 Receptor Binding Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Autophagy Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Regulation Of Cell Adhesion Regulation Of Actin Cytoskeleton Organization Cellular Response To Oxidative Stress Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Protein Modification Process Cellular Response To Retinoic Acid Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Cell Motility Positive Regulation Of T Cell Migration	Apoptotic Process Activation-induced Cell Death Of T Cells Negative Regulation Of Canonical NF-kappaB Signal Transduction Symbiont Entry Into Host Cell T Cell Receptor Signaling Pathway T Cell Apoptotic Process Extrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Pathways		Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling RAC1 GTPase cycle RAC3 GTPase cycle Negative regulation of FLT3
Drugs		ATP Dasatinib XL228 K-00546 Fostamatinib	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		IgE grass sensitization ( 22036096)	Endometrial cancer ( 27135401) Endometrial endometrioid carcinoma ( 27135401) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		34 interacting genes: ABL1 AR BCR CAT COXFA4L3 CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK KIT MAP3K10 MDM2 MET NEDD4 NEDD4L OIP5 PDGFRB PIK3R3 PRRG4 PSMA7 RIN1 SIVA1 SORBS2 STAT3 TPD52L1 TRIP10 ZMAT1	33 interacting genes: ABL2 APP AQP1 BCL2 BCL2L1 BEX3 C2orf68 CATSPER1 CD27 CD4 CDKN2A CREB5 HOXA1 ING3 KRTAP26-1 MEFV NEDD4 NEDD4L NTAQ1 PCBP1 PCNA PM20D2 POLR2M PXMP2 RAD18 RHOU SSBP3 TCAP TFAP2D TNFRSF4 TXNIP UBE2D1 ZNF446
Entrez ID		27	10572
HPRD ID		01259	16124
Ensembl ID		ENSG00000143322	ENSG00000184990
Uniprot IDs		P42684	O15304
PDB IDs		2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH 5NP3 5NP5
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Phosphorylation Peptidyl-tyrosine Phosphorylation Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Population Proliferation Receptor Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Signaling Regulation Of Cell Communication Response To Growth Factor Positive Regulation Of Locomotion Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Migration Basal Plasma Membrane Transferase Activity Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Biological Quality Regulation Of Cell Motility Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Locomotion	Response To Hydrogen Peroxide Channel Inhibitor Activity Identical Protein Binding Response To Reactive Oxygen Species Dendritic Cell Apoptotic Process Response To Radiation Response To Light Stimulus Response To Metal Ion BH3 Domain Binding Negative Regulation Of Potassium Ion Export Across Plasma Membrane Response To Oxidative Stress Channel Activity Regulation Of Metabolic Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Regulation Of Transcription By RNA Polymerase II Regulation Of Mononuclear Cell Proliferation Regulation Of B Cell Activation Negative Regulation Of Dendritic Cell Apoptotic Process Bcl-2 Family Protein Complex Sodium Channel Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Potassium Channel Inhibitor Activity Regulation Of Cell Activation Regulation Of Primary Metabolic Process Regulation Of Membrane Potential Regulation Of Monoatomic Ion Transmembrane Transport Response To UV Protein Polyubiquitination Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Leukocyte Apoptotic Process Ubiquitin Ligase Inhibitor Activity Regulation Of Potassium Ion Export Across Plasma Membrane Protein Monoubiquitination Regulation Of Macromolecule Metabolic Process Regulation Of Apoptotic Process Cellular Response To Hydrogen Peroxide Regulation Of B Cell Proliferation T Cell Activation Positive Regulation Of Leukocyte Proliferation Negative Regulation Of Sodium Ion Transport Cellular Response To Radiation Negative Regulation Of Cation Transmembrane Transport Regulation Of Mitochondrial Membrane Potential Regulation Of Programmed Cell Death Apoptotic Signaling Pathway Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Monoatomic Ion Transmembrane Transport
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