ABL2 and FBXO38

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ABL2	FBXO38
Gene Name		ABL proto-oncogene 2, non-receptor tyrosine kinase	F-box protein 38
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Cytosol Actin Cytoskeleton Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Dendritic Spine	Nucleus Cytoplasm
	Molecular Function	Magnesium Ion Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding
	Biological Process	Cellular Protein Modification Process Phagocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Visual Learning Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Neuron Remodeling Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Regulation Of Endocytosis Regulation Of Cell Adhesion Positive Regulation Of Protein Binding Cellular Protein Localization Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Alpha-beta T Cell Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Dendrite Morphogenesis Neuromuscular Process Controlling Balance Actin Filament Bundle Assembly Positive Regulation Of Oxidoreductase Activity Bergmann Glial Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Dendritic Spine Maintenance Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Interferon-gamma Secretion Regulation Of Extracellular Matrix Organization Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Role of Abl in Robo-Slit signaling Axon guidance Signaling by Robo receptor
Drugs		Adenosine triphosphate Dasatinib 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Diseases
GWAS		IgE grass sensitization ( 22036096)	Periodontal microbiota ( 22699663)
Protein-Protein Interactions		25 interactors: ABL1 BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK MAP3K10 NEDD4 NEDD4L OIP5 PSMA7 RIN1 SIVA1 SORBS2 TPD52L1 TRIP10	6 interactors: ABL2 APP KLF7 PPM1G RING1 SOX30
Entrez ID		27	81545
HPRD ID		01259	09775
Ensembl ID		ENSG00000143322	ENSG00000145868
Uniprot IDs		P42684	Q6AZE0 Q6PIJ6
PDB IDs		2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Communication Protein Autophosphorylation Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Immune Response Signaling Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Locomotion Response To Organic Substance Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Cell Death Response To Growth Factor Neurotrophin Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Immune System Process Positive Regulation Of MAPK Cascade Cellular Protein Modification Process Regulation Of Protein Metabolic Process Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Response To Stimulus Positive Regulation Of Metabolic Process Response To Stress Regulation Of Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway	Neuron Remodeling Dendrite Development Neuron Maturation Axon Guidance Visual Learning Visual Behavior Neuromuscular Process Controlling Balance Dendrite Morphogenesis Associative Learning Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Neuromuscular Process Synaptic Growth At Neuromuscular Junction Learning Cell Morphogenesis Involved In Differentiation Regulation Of Protein Binding Cell Maturation Collateral Sprouting In Absence Of Injury Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Positive Regulation Of Interferon-gamma Secretion Collateral Sprouting Axon Midline Choice Point Recognition Neuron Development Anatomical Structure Morphogenesis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Cell Morphogenesis Axon Choice Point Recognition Regulation Of Binding Learning Or Memory Bergmann Glial Cell Differentiation Neuron Differentiation Cell Projection Organization Cognition Cellular Calcium Ion Homeostasis Dendritic Spine Maintenance Calcium Ion Homeostasis Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Interleukin-2 Secretion Locomotion Response To Light Stimulus Positive Regulation Of Non-canonical Wnt Signaling Pathway Substrate-dependent Cell Migration, Cell Extension Histone H2A Monoubiquitination Peptidyl-threonine Dephosphorylation Histone H2A Ubiquitination
Tagcloud ?		abl1 adding amenable charities crizotinib crlf2 csf1r dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined	18s actb ap3d1 bestkeeper c2c12 cdc40 csnk2a2 dystrophic dystrophin exceptionally fbxw2 gapdh genorm h2k2b4 h2ksf1 htatsf1 informative mef2c myoblasts myod myogenesis myogenic myogenin normalization normalizing normfinder packages pak1ip1 zfp91
Tagcloud (Difference) ?		abl1 adding amenable charities crizotinib crlf2 csf1r dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined	18s actb ap3d1 bestkeeper c2c12 cdc40 csnk2a2 dystrophic dystrophin exceptionally fbxw2 gapdh genorm h2k2b4 h2ksf1 htatsf1 informative mef2c myoblasts myod myogenesis myogenic myogenin normalization normalizing normfinder packages pak1ip1 zfp91
Tagcloud (Intersection) ?