ABL2 and DOK1

Number of citations of the paper that reports this interaction (PMID 22974441)
2

Data Source:
BioGRID (unspecified method)

		ABL2	DOK1
Gene Name		ABL proto-oncogene 2, non-receptor tyrosine kinase	docking protein 1, 62kDa (downstream of tyrosine kinase 1)
Image
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Cytosol Actin Cytoskeleton Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Dendritic Spine	Nucleus Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Magnesium Ion Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding	Receptor Signaling Protein Activity Insulin Receptor Binding Protein Binding
	Biological Process	Cellular Protein Modification Process Phagocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Visual Learning Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Neuron Remodeling Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Regulation Of Endocytosis Regulation Of Cell Adhesion Positive Regulation Of Protein Binding Cellular Protein Localization Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Alpha-beta T Cell Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Dendrite Morphogenesis Neuromuscular Process Controlling Balance Actin Filament Bundle Assembly Positive Regulation Of Oxidoreductase Activity Bergmann Glial Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Dendritic Spine Maintenance Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Interferon-gamma Secretion Regulation Of Extracellular Matrix Organization Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Insulin Receptor Signaling Pathway
Pathways		Role of Abl in Robo-Slit signaling Axon guidance Signaling by Robo receptor	IRS-related events triggered by IGF1R Insulin receptor signalling cascade IRS activation IRS-mediated signalling Signal attenuation IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) IRS-related events IGF1R signaling cascade PI3K Cascade PI3K Cascade Signaling by Insulin receptor
Drugs		Adenosine triphosphate Dasatinib 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Diseases
GWAS		IgE grass sensitization ( 22036096)
Protein-Protein Interactions		25 interactors: ABL1 BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK MAP3K10 NEDD4 NEDD4L OIP5 PSMA7 RIN1 SIVA1 SORBS2 TPD52L1 TRIP10	39 interactors: ABL1 ABL2 BCR CRK CRKL CSK ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC VAV1 YES1
Entrez ID		27	1796
HPRD ID		01259	04228
Ensembl ID		ENSG00000143322	ENSG00000115325
Uniprot IDs		P42684	B3KP83 B4DJN1 Q2TA81 Q99704
PDB IDs		2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH	2V76
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Communication Protein Autophosphorylation Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Immune Response Signaling Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Locomotion Response To Organic Substance Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Cell Death Response To Growth Factor Neurotrophin Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Immune System Process Positive Regulation Of MAPK Cascade Cellular Protein Modification Process Regulation Of Protein Metabolic Process Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Response To Stimulus Positive Regulation Of Metabolic Process Response To Stress Regulation Of Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Locomotion Cell Migration Immune System Process Cell Surface Receptor Signaling Pathway Cell Motility Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Protein Autophosphorylation Movement Of Cell Or Subcellular Component Regulation Of Immune System Process Leukocyte Migration Innate Immune Response Fc Receptor Signaling Pathway Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Communication Signal Transduction Immune Response Defense Response Wound Healing Blood Coagulation Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Hemostasis Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation ERBB Signaling Pathway Response To Wounding Cellular Response To Stimulus Single Organismal Cell-cell Adhesion Cellular Response To Organic Substance Peptidyl-amino Acid Modification Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Cell Activation Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Cell Activation Regulation Of Body Fluid Levels Chemotaxis Regulation Of Cell Adhesion Response To Stimulus Antigen Receptor-mediated Signaling Pathway Regulation Of Signaling
Tagcloud ?		abl1 adding amenable charities crizotinib crlf2 csf1r dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined	adaptors coimmunoprecipitated comprises epcs epo epor erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 stam2 transducing ut7epo validating
Tagcloud (Difference) ?		abl1 adding amenable charities crizotinib crlf2 csf1r dasatinib etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined	adaptors coimmunoprecipitated comprises epcs epo erythroblast erythroblasts gab1 hemoglobinizing homo irs2 orf phosphoproteomics phosphotyrosine primates propagates py rhex sapiens sh2d2a shc1 sprouty spry1 spry2 stam2 transducing ut7epo validating
Tagcloud (Intersection) ?		epor