ABL2 and RIN1

Number of citations of the paper that reports this interaction (PMID 15886098)
29

Data Source:
HPRD (in vivo)

		ABL2	RIN1
Gene Name		ABL proto-oncogene 2, non-receptor tyrosine kinase	Ras and Rab interactor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Phagocytic Cup Cytosol Actin Cytoskeleton Lamellipodium Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Dendritic Spine	Cytoplasm Cytoskeleton Plasma Membrane Dendrite Neuronal Cell Body
	Molecular Function	Magnesium Ion Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding	GTPase Activator Activity Protein Binding Ras GTPase Binding
	Biological Process	Cellular Protein Modification Process Phagocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Visual Learning Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Neuron Remodeling Cell Migration Peptidyl-tyrosine Phosphorylation Cerebellum Morphogenesis Negative Regulation Of Cell-cell Adhesion Regulation Of Endocytosis Regulation Of Cell Adhesion Positive Regulation Of Protein Binding Cellular Protein Localization Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Alpha-beta T Cell Differentiation Platelet-derived Growth Factor Receptor Signaling Pathway Dendrite Morphogenesis Neuromuscular Process Controlling Balance Actin Filament Bundle Assembly Positive Regulation Of Oxidoreductase Activity Bergmann Glial Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Dendritic Spine Maintenance Positive Regulation Of Interleukin-2 Secretion Positive Regulation Of Interferon-gamma Secretion Regulation Of Extracellular Matrix Organization Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization Negative Regulation Of Endothelial Cell Apoptotic Process	Endocytosis Signal Transduction Memory Associative Learning Negative Regulation Of Synaptic Plasticity Positive Regulation Of GTPase Activity
Pathways		Role of Abl in Robo-Slit signaling Axon guidance Signaling by Robo receptor
Drugs		Adenosine triphosphate Dasatinib 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Diseases
GWAS		IgE grass sensitization ( 22036096)	Bipolar disorder ( 21926972)
Protein-Protein Interactions		25 interactors: ABL1 BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK MAP3K10 NEDD4 NEDD4L OIP5 PSMA7 RIN1 SIVA1 SORBS2 TPD52L1 TRIP10	15 interactors: ABL1 ABL2 CALCOCO2 ERBB2 ERBB3 HRAS LZTS2 MLLT4 RAB5A RAB5B RALGDS RRAS2 YWHAB YWHAE YWHAZ
Entrez ID		27	9610
HPRD ID		01259	05813
Ensembl ID		ENSG00000143322	ENSG00000174791
Uniprot IDs		P42684	Q13671
PDB IDs		2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH
Enriched GO Terms of Interacting Partners?		Regulation Of Signaling Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell Communication Protein Autophosphorylation Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Immune Response Signaling Positive Regulation Of Protein Metabolic Process Cellular Response To Stimulus Locomotion Response To Organic Substance Immune Response-regulating Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transferase Activity Cellular Response To Organic Substance Cellular Response To Growth Factor Stimulus Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Catalytic Activity Regulation Of Cell Death Response To Growth Factor Neurotrophin Signaling Pathway Regulation Of MAPK Cascade Positive Regulation Of Protein Modification Process Peptidyl-amino Acid Modification Regulation Of Immune System Process Positive Regulation Of MAPK Cascade Cellular Protein Modification Process Regulation Of Protein Metabolic Process Phosphatidylinositol-mediated Signaling Positive Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Response To Stimulus Positive Regulation Of Metabolic Process Response To Stress Regulation Of Kinase Activity Regulation Of Catalytic Activity Positive Regulation Of Cellular Protein Metabolic Process Fibroblast Growth Factor Receptor Signaling Pathway	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ras Protein Signal Transduction Neurotrophin Signaling Pathway Regulation Of Signaling Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signaling Cell Communication Apoptotic Signaling Pathway Regulation Of Signal Transduction Intrinsic Apoptotic Signaling Pathway Response To Stimulus Cellular Response To Stimulus Innate Immune Response Positive Regulation Of Signal Transduction Immune Response Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Defense Response Regulation Of Cellular Component Organization Fc Receptor Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Small GTPase Mediated Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Catalytic Activity Immune System Process Regulation Of Cell Death Regulation Of Cellular Localization Regulation Of Actin Cytoskeleton Reorganization Positive Regulation Of Interferon-gamma Secretion Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Response To Wounding Regulation Of Catalytic Activity Axon Guidance Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Transport Regulation Of Intracellular Signal Transduction Glial Cell Differentiation Regulation Of Endocytosis Response To Organic Substance Negative Regulation Of Protein Dephosphorylation Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Protein Localization
Tagcloud ?		abl1 adding amenable charities crizotinib crlf2 csf1r dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined	abcc12 braf dabrafenib deregulated deserve detoxification discover exploratory highlighted invasiveness klf17 melanoma mtefd1 nqo1 peaks rbm10 responder responders seldi silico slain1 strongest surrogates tox3 tspo2 v600 vemurafenib z zbtb44
Tagcloud (Difference) ?		abl1 adding amenable charities crizotinib crlf2 csf1r dasatinib epor etv6 flt3 funded fusions il7r lebanese lymphoblastic ntrk3 pdgfrb ph philadelphia ptk2b rearrangements responsiveness ruxolitinib sh2b3 syrian tslp tyk2 undefined	abcc12 braf dabrafenib deregulated deserve detoxification discover exploratory highlighted invasiveness klf17 melanoma mtefd1 nqo1 peaks rbm10 responder responders seldi silico slain1 strongest surrogates tox3 tspo2 v600 vemurafenib z zbtb44
Tagcloud (Intersection) ?