ABL2 and MAP3K10

Number of citations of the paper that reports this interaction (PubMedID 20936779)
36

Data Source:
BioGRID (two hybrid)

		ABL2	MAP3K10
Description		ABL proto-oncogene 2, non-receptor tyrosine kinase	mitogen-activated protein kinase kinase kinase 10
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Actin Cytoskeleton	Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Phosphotyrosine Residue Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Kinase Activity Transferase Activity Enzyme Binding Manganese Ion Binding Metal Ion Binding Actin Filament Binding	Nucleotide Binding Transcription Corepressor Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Homodimerization Activity BHLH Transcription Factor Binding Protein Serine Kinase Activity
	Biological Process	Cell Adhesion Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Autophagy Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Regulation Of Cell Adhesion Regulation Of Actin Cytoskeleton Organization Cellular Response To Oxidative Stress Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Protein Modification Process Cellular Response To Retinoic Acid Positive Regulation Of Establishment Of T Cell Polarity Regulation Of Cell Motility Positive Regulation Of T Cell Migration	Apoptotic Process Signal Transduction Smoothened Signaling Pathway JNK Cascade Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of JUN Kinase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of JNK Cascade Protein Autophosphorylation
Pathways		Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling RAC1 GTPase cycle RAC3 GTPase cycle Negative regulation of FLT3
Drugs		ATP Dasatinib XL228 K-00546 Fostamatinib	Fostamatinib
Diseases
GWAS		IgE grass sensitization ( 22036096)	Birth weight ( 31043758) Resting heart rate ( 27798624)
Interacting Genes		34 interacting genes: ABL1 AR BCR CAT COXFA4L3 CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK KIT MAP3K10 MDM2 MET NEDD4 NEDD4L OIP5 PDGFRB PIK3R3 PRRG4 PSMA7 RIN1 SIVA1 SORBS2 STAT3 TPD52L1 TRIP10 ZMAT1	31 interacting genes: ABL2 CDC42 CEACAM1 CLTC CNKSR1 COPS2 DLG4 DNM1 DNM1L GARS1 HGS HTT KIF17 KIF3A KIF3B KIFAP3 LCOR MAP2K4 MAPK1 MAPK14 MAPK8IP1 MAPK8IP2 MAPK9 NEUROD1 PHB1 RAC1 RACGAP1 SH3RF1 SMURF1 TUBB YWHAE
Entrez ID		27	4294
HPRD ID		01259	02533
Ensembl ID		ENSG00000143322	ENSG00000130758
Uniprot IDs		P42684	Q02779
PDB IDs		2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH 5NP3 5NP5	2RF0
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of MAPK Cascade Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Kinase Activity Protein Kinase Activity Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cellular Component Organization Phosphotyrosine Residue Binding Regulation Of Programmed Cell Death Phosphorylation Peptidyl-tyrosine Phosphorylation Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Cell Migration Positive Regulation Of Cell Population Proliferation Receptor Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction ERBB2 Signaling Pathway Positive Regulation Of Cell Motility Regulation Of Signaling Regulation Of Cell Communication Response To Growth Factor Positive Regulation Of Locomotion Positive Regulation Of Phosphate Metabolic Process Regulation Of Cell Migration Basal Plasma Membrane Transferase Activity Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Biological Quality Regulation Of Cell Motility Intracellular Signaling Cassette Negative Regulation Of Apoptotic Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Locomotion	MAPK Cascade Kinesin II Complex Protein Phosphatase Binding Cytoplasm Vesicle-mediated Transport Cytoskeleton-dependent Intracellular Transport Plus-end-directed Vesicle Transport Along Microtubule Regulation Of Signal Transduction Dendrite Cytoplasm Signal Transduction Intracellular Signaling Cassette Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Plus-end-directed Organelle Transport Along Microtubule Cytosol Organelle Transport Along Microtubule Regulation Of Multicellular Organismal Process Transport Along Microtubule Nucleotide Binding Anterograde Dendritic Transport Regulation Of Cell Communication Regulation Of Signaling Endocytosis Extracellular Exosome Protein Kinase Binding Intracellular Protein Localization Cellular Localization Vesicle Transport Along Microtubule Kinesin Complex MAP-kinase Scaffold Activity Membrane Invagination Receptor Localization To Synapse Regulation Of Transport Regulation Of Immune System Process Microtubule Microtubule-based Transport MAP Kinase Activity Positive Regulation Of Cellular Component Organization Vesicle Cytoskeletal Trafficking Postsynapse Dendritic Transport Negative Regulation Of Signal Transduction JNK Cascade Cell Surface Receptor Signaling Pathway Mitotic Spindle Intracellular Transport Regulation Of Vesicle-mediated Transport Plus-end-directed Microtubule Motor Activity Microtubule Binding Microtubule Cytoskeleton Positive Regulation Of Leukocyte Migration
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