AKAP8L and ICAM4

		AKAP8L	ICAM4
Description		A-kinase anchoring protein 8 like	intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Matrix PML Body Nuclear Speck Ribonucleoprotein Complex	Extracellular Region Plasma Membrane Membrane
	Molecular Function	DNA Binding RNA Binding Protein Binding Lamin Binding Zinc Ion Binding DEAD/H-box RNA Helicase Binding Protein Kinase A Regulatory Subunit Binding Histone Deacetylase Binding Metal Ion Binding	Integrin Binding Protein Binding
	Biological Process	MRNA Processing Mitotic Chromosome Condensation RNA Splicing Regulation Of MRNA Export From Nucleus Cell Cycle G2/M Phase Transition Positive Regulation Of Transcription By RNA Polymerase II Nuclear Membrane Disassembly	Cell Adhesion Cell-cell Adhesion
Pathways		Formation of WDR5-containing histone-modifying complexes	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions
Drugs
Diseases
GWAS		Red blood cell count ( 32888494)	Blood protein levels ( 30072576)
Interacting Genes		60 interacting genes: ABI2 ATOSB ATPAF2 CARHSP1 CATSPER1 CCDC120 CCDC24 CDC6 CNNM3 CREB5 CSTF2 CSTF2T DGCR6 DHX9 DMRT3 DSCR9 EMD ENKD1 FOXD4 GPANK1 GPS2 HEMK1 HGS HSF4 HUNK INCA1 KPRP LAGE3 LBR MYOZ1 MYPOP PATZ1 PCDHB14 PEF1 PITX1 PLEKHN1 PRKAA2 PRKACA PRPF40A PTP4A2 RAMAC RTP5 RUSC1 SAMD4A SAXO1 SAXO4 SH3RF2 SNRPC TEKT4 TEKT5 TENT5B TFAP2D TIAL1 TLE5 TMPO TMSB4X TRIB3 TSGA10IP WDR25 ZNF366	14 interacting genes: CREB3 CYSRT1 ITGA4 ITGAM ITGAV ITGB1 ITGB2 KRT31 KRT34 KRTAP5-9 MTUS2 NBPF19 NOTCH2NLA RHAG
Entrez ID		26993	3386
HPRD ID		10641	00198
Ensembl ID		ENSG00000011243	ENSG00000105371
Uniprot IDs		Q9ULX6	Q14773 U5U6P8
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Sperm Flagellum	Integrin Complex Heterotypic Cell-cell Adhesion C-X3-C Chemokine Binding Cell Adhesion Mediated By Integrin Integrin-mediated Signaling Pathway Cell-matrix Adhesion Integrin Binding Cell-substrate Adhesion Integrin AlphaM-beta2 Complex Integrin Alphav-beta1 Complex Fibronectin Binding Integrin Alpha4-beta1 Complex Positive Regulation Of Neutrophil Degranulation Endodermal Cell Differentiation Negative Regulation Of Dopamine Metabolic Process Epidermis Development Negative Regulation Of Catecholamine Metabolic Process Receptor-mediated Endocytosis Leukocyte Cell-cell Adhesion Cell-cell Adhesion Mediated By Integrin Regulation Of Neutrophil Degranulation Coreceptor Activity Tissue Development Endocytosis Complement Component C3b Binding Cell-cell Adhesion Specific Granule Membrane Negative Regulation Of Vasoconstriction Signaling Receptor Activity Cell Adhesion Molecule Binding Phagocytosis Wound Healing, Spreading Of Epidermal Cells Import Into Cell Leukocyte Tethering Or Rolling Regulation Of Dopamine Metabolic Process Positive Regulation Of Superoxide Anion Generation Regulation Of Superoxide Anion Generation Cell Surface Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell External Side Of Plasma Membrane Cellular Developmental Process Cargo Receptor Activity Positive Regulation Of Protein Targeting To Membrane Amyloid-beta Clearance Regulation Of Superoxide Metabolic Process Wound Healing, Spreading Of Cells Microglial Cell Activation Phagocytosis, Engulfment Cell Differentiation
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