SLC18A1 and MIP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SLC18A1	MIP
Description		solute carrier family 18 member A1	major intrinsic protein of lens fiber
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Terminal Bouton Synapse Clathrin-sculpted Monoamine Transport Vesicle Membrane Presynapse	Plasma Membrane Membrane Apical Plasma Membrane Anchoring Junction
	Molecular Function	Serotonin:sodium:chloride Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Monoamine:proton Antiporter Activity Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity	Structural Constituent Of Eye Lens Protein Binding Calmodulin Binding Water Channel Activity Channel Activity Cell Adhesion Mediator Activity
	Biological Process	Neurotransmitter Transport Serotonin Transport Aminergic Neurotransmitter Loading Into Synaptic Vesicle Monoamine Transport Dopamine Transport Xenobiotic Transport Serotonin Uptake Norepinephrine Uptake Establishment Of Localization In Cell Transmembrane Transport Dopamine Uptake Proton Transmembrane Transport	Lens Development In Camera-type Eye Water Transport Visual Perception Homotypic Cell-cell Adhesion Maintenance Of Lens Transparency Transmembrane Transport Gap Junction-mediated Intercellular Transport
Pathways			Passive transport by Aquaporins
Drugs		Reserpine Norepinephrine Ephedra sinica root MMDA Metamfetamine	B-nonylglucoside
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Cholesterol ( 31902109) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Hypertriglyceridemia ( 23505323) Major depressive disorder (broad) ( 20038947) Metabolic syndrome ( 30382898 31589552) Persistent hepatitis B virus infection ( 27244555) Pulse pressure ( 27841878) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Triglyceride levels in HIV infection ( 33109212) Triglycerides ( 18193046 24886709)	Axial length ( 24144296) Lipoprotein (a) levels ( 33730874) Serum metabolite levels ( 33031748)
Interacting Genes		88 interacting genes: ADGRE2 AGTRAP ANKRD46 APOL2 BRICD5 BTN2A2 C1GALT1 C2CD2L CCL4 CCL4L2 CD81 CNIH1 COL4A5 CTSA CXCL16 CYB561D2 ERMP1 FAM3C FCER1G FXYD3 GIMAP1 GJB2 GPR151 HTATIP2 INSIG2 LAT MALL MARCHF2 MFSD6 MGAM MGLL MIP MS4A1 MS4A13 NEU1 NRM OLFM4 ORMDL1 PEX16 PLP1 PLP2 PMP22 PNLIPRP1 RABAC1 RPRM SCD SEC22A SELENOK SERP1 SLC30A2 SLC30A3 SLC30A8 SLC35B4 SLC35G1 SLC38A7 SLC39A2 SMCO4 SMIM1 STX2 STX7 STX8 SYNGR1 TECR TFRC TMEM120B TMEM128 TMEM147 TMEM14A TMEM14B TMEM14C TMEM203 TMEM218 TMEM239 TMEM42 TMEM60 TMEM65 TMEM86A TMEM97 TSPO2 UPK1B UPK2 VAMP5 VAPA VAPB VTI1B YIPF1 YIPF4 YIPF6	48 interacting genes: AQP6 AQP9 ATP6V0B CALM1 CD40 CISD2 CLDN5 CRYAA CRYAB CRYBB2 CRYGC ERGIC3 ERVFRD-1 FAM209A FCGR2A FOXA2 GJA3 GJA8 GJB5 GOLM1 GPX8 KCNJ6 LHFPL5 LMNA LRRC4C MFF MGST3 MRM3 MRPS18B MUC1 PDZK1IP1 PRKACA RELL2 SAR1A SGPL1 SLC14A1 SLC18A1 SSMEM1 STX1A STX2 SYAP1 SYT1 SYT2 TMEM139 TMEM154 TMEM52B TMX2 ZFPL1
Entrez ID		6570	4284
HPRD ID		01897	01098
Ensembl ID		ENSG00000036565	ENSG00000135517
Uniprot IDs		P54219 Q96GL6	P30301
PDB IDs		8TGG 8TGH 8TGI 8TGJ 8TGK 8TGL 8TGM 8TGN
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Plasma Membrane Membrane Docking Protein Binding SNAP Receptor Activity Organelle Localization By Membrane Tethering Chloride Channel Inhibitor Activity Membrane Organization Zinc Ion Transmembrane Transporter Activity Vesicle-mediated Transport Zinc Ion Transmembrane Transport Zinc Ion Transport Membrane Fusion Zinc Ion Import Into Organelle Cellular Localization Endomembrane System FFAT Motif Binding Monoatomic Cation Transmembrane Transporter Activity SNARE Complex Zinc Ion Import Into Lysosome Vesicle Fusion Organelle Membrane Fusion Lysosome Zinc:proton Antiporter Activity COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Vesicle Docking Establishment Of Localization In Cell Vesicle SNARE Binding Intracellular Transport Fatty Acid Biosynthetic Process Gap Junction-mediated Intercellular Transport Cytoplasmic Vesicle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process In The Vacuole Endoplasmic Reticulum Localization Vesicle Fusion With Golgi Apparatus Organelle Fusion Golgi Vesicle Transport Transmembrane Transport Lysosomal Membrane Vacuolar Transmembrane Transport Synaptic Vesicle Golgi Trans Cisterna Secretory Vesicle Golgi Medial Cisterna Metal Ion Transport	Membrane Lens Development In Camera-type Eye Structural Constituent Of Eye Lens Structural Molecule Activity Urea Channel Activity Gap Junction Channel Activity Connexin Complex SNARE Binding Synaptic Vesicle Membrane One-carbon Compound Transport Water Transport Gap Junction Calcium-dependent Protein Binding Organelle Localization By Membrane Tethering Clathrin-sculpted Monoamine Transport Vesicle Membrane Urea Transmembrane Transporter Activity Membrane Docking Camera-type Eye Development Gap Junction-mediated Intercellular Transport Fluid Transport Plasma Membrane Protein Binding Regulation Of Calcium Ion-dependent Exocytosis Chromaffin Granule Membrane Urea Transmembrane Transport Tubulin Complex Assembly Intercellular Transport Amine Transport Urea Transport Modulation Of Chemical Synaptic Transmission Eye Development Positive Regulation Of Catecholamine Secretion Calcium-dependent Activation Of Synaptic Vesicle Fusion Water Channel Activity Calcium Channel Inhibitor Activity Vesicle Docking Detection Of Calcium Ion Positive Regulation Of Calcium Ion-dependent Exocytosis Dense Core Granule Calcium Ion Sensor Activity Voltage-gated Potassium Channel Complex Sensory Organ Development Positive Regulation Of Neurotransmitter Secretion Positive Regulation Of Dendrite Extension Positive Regulation Of Vesicle Fusion Glutathione Peroxidase Activity
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