CACNB3 and CACNA1C

Number of citations of the paper that reports this interaction (PMID 15170217)
83

Data Source:
HPRD (in vitro)

		CACNB3	CACNA1C
Gene Name		calcium channel, voltage-dependent, beta 3 subunit	calcium channel, voltage-dependent, L type, alpha 1C subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Voltage-gated Calcium Channel Complex Membrane Apical Plasma Membrane	Caveolar Macromolecular Signaling Complex Cytoplasm Plasma Membrane Voltage-gated Calcium Channel Complex Postsynaptic Density Integral Component Of Membrane Z Disc Neuronal Cell Body Dendritic Shaft
	Molecular Function	Voltage-gated Calcium Channel Activity High Voltage-gated Calcium Channel Activity Protein Kinase Binding	Voltage-gated Calcium Channel Activity Protein Binding Calmodulin Binding High Voltage-gated Calcium Channel Activity Enzyme Binding Metal Ion Binding Alpha-actinin Binding
	Biological Process	Transport Calcium Ion Transport Synaptic Transmission Axon Guidance Neuromuscular Junction Development T Cell Receptor Signaling Pathway Membrane Depolarization Calcium Ion Transmembrane Transport Regulation Of Voltage-gated Calcium Channel Activity	Energy Reserve Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission Axon Guidance Adult Walking Behavior Regulation Of Blood Pressure Visual Learning Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Ion-dependent Exocytosis Regulation Of Vasoconstriction Insulin Secretion Growth Hormone Secretion Regulation Of Ion Transmembrane Transport Calcium-mediated Signaling Using Extracellular Calcium Source Glucose Homeostasis Small Molecule Metabolic Process Regulation Of Organ Growth Regulation Of Insulin Secretion Smooth Muscle Contraction Involved In Micturition Calcium Ion Transport Into Cytosol Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses Adrenaline,noradrenaline inhibits insulin secretion	NCAM1 interactions Axon guidance Integration of energy metabolism Regulation of insulin secretion NCAM signaling for neurite out-growth Adrenaline,noradrenaline inhibits insulin secretion
Drugs			Isradipine Ibutilide Amlodipine Nimodipine Nisoldipine Cinnarizine Nicardipine Magnesium Sulfate Verapamil Felodipine Nitrendipine Nifedipine Calcium Mibefradil Dronedarone Clevidipine Nilvadipine Drotaverine
Diseases
GWAS			Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 18711365) Bipolar disorder and major depressive disorder (combined) ( 20351715) Red blood cell traits ( 23222517) Schizophrenia ( 21926974 22688191) Sleep quality ( 23728906) Warfarin maintenance dose ( 18535201)
Protein-Protein Interactions		4 interactors: CACNA1B CACNA1C FASLG SYT1	11 interactors: CABP1 CACNB3 COPS5 GNB1 HDAC4 PCBD1 PPM1A PRKACA RIMS1 RYR2 SRI
Entrez ID		784	775
HPRD ID		11879	00246
Ensembl ID		ENSG00000167535
Uniprot IDs		P54284	Q13936
PDB IDs			1T0J 2BE6 2F3Y 2F3Z 2LQC 3G43 3OXQ
Enriched GO Terms of Interacting Partners?		Cell-cell Signaling Calcium Ion Import Membrane Depolarization During Action Potential Secretion By Cell Synaptic Transmission Secretion Action Potential Neurotransmitter Secretion Membrane Depolarization Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Neurotransmitter Levels Neurotransmitter Transport Regulation Of Heart Contraction Regulation Of Blood Pressure Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Transport Smooth Muscle Contraction Involved In Micturition Calcium-mediated Signaling Using Extracellular Calcium Source Endosomal Lumen Acidification Locomotory Behavior Retinal Cell Programmed Cell Death Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Membrane Potential Necroptotic Signaling Pathway Calcium Ion Transport Blood Circulation Micturition Exocytosis Cellular Chloride Ion Homeostasis Inflammatory Cell Apoptotic Process Chloride Ion Homeostasis Ion Transport Urinary Bladder Smooth Muscle Contraction Regulation Of Ion Transmembrane Transport Positive Regulation Of Endothelial Cell Apoptotic Process Growth Hormone Secretion Detection Of Calcium Ion Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Cation Homeostasis Cellular Ion Homeostasis Establishment Of Localization In Cell Positive Regulation Of Calcium Ion-dependent Exocytosis Cell Communication By Electrical Coupling Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion T Cell Apoptotic Process Cellular Chemical Homeostasis Positive Regulation Of Vesicle Fusion Signaling Ion Homeostasis Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Cation Channel Activity Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Regulation Of Voltage-gated Calcium Channel Activity Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cellular Response To Catecholamine Stimulus Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Muscle Contraction Regulation Of Ion Transmembrane Transport Regulation Of Heart Contraction Regulation Of Intracellular Transport Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Protein Import Into Nucleus Regulation Of Binding Regulation Of Intracellular Protein Transport Regulation Of Ion Transport Regulation Of Heart Rate Regulation Of Membrane Potential Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Intracellular Protein Transport Calcium-mediated Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Cell Communication By Electrical Coupling Cell Communication By Electrical Coupling Negative Regulation Of Intracellular Transport Negative Regulation Of Transport Cellular Metal Ion Homeostasis Cellular Response To Epinephrine Stimulus Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Negative Regulation Of Calcium Ion Transmembrane Transporter Activity Cell-cell Signaling Response To Epinephrine Second-messenger-mediated Signaling Cellular Cation Homeostasis Regulation Of Protein Binding Negative Regulation Of Cation Channel Activity Cellular Ion Homeostasis Metal Ion Homeostasis Cellular Response To Organonitrogen Compound Regulation Of Ion Homeostasis
Tagcloud ?		acinus adapter alg2 casp3 coinduction competing elucidating ercc3 fem1 gadd153 gadd34 gated gsn helps hereditary heretofore igf1 igfbp2 ischemia modules muscular nrp1 oligodeoxynucleotide permits smn1 tfdp1 tiar vim	ad1 ad2 ad3 aom azoxymethane bcorl1 c57bl carcinogenesis colitis colon dextran dss dysplasia foxo3 gradually irrelevant itk kcna1 microarray mir named pictar preliminarily regular rspo2 sequentially sulfate targetscan tle4
Tagcloud (Difference) ?		acinus adapter alg2 casp3 coinduction competing elucidating ercc3 fem1 gadd153 gadd34 gated gsn helps hereditary heretofore igf1 igfbp2 ischemia modules muscular nrp1 oligodeoxynucleotide permits smn1 tfdp1 tiar vim	ad1 ad2 ad3 aom azoxymethane bcorl1 c57bl carcinogenesis colitis colon dextran dss dysplasia foxo3 gradually irrelevant itk kcna1 microarray mir named pictar preliminarily regular rspo2 sequentially sulfate targetscan tle4
Tagcloud (Intersection) ?