GDF2 and ACVR2A

Number of citations of the paper that reports this interaction (PMID 22718755)
11

Data Source:
BioGRID (pull down)

		GDF2	ACVR2A
Gene Name		growth differentiation factor 2	activin A receptor, type IIA
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Inhibin-betaglycan-ActRII Complex Receptor Complex
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Coreceptor Activity Activin-activated Receptor Activity Growth Factor Binding PDZ Domain Binding Inhibin Binding Protein Self-association Metal Ion Binding Activin Binding
	Biological Process	Ossification Angiogenesis Patterning Of Blood Vessels Vasculogenesis Osteoblast Differentiation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Cellular Iron Ion Homeostasis Negative Regulation Of DNA Replication Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Interleukin-8 Production Activin Receptor Signaling Pathway Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Development Blood Vessel Morphogenesis Cartilage Development Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Cellular Response To BMP Stimulus Negative Regulation Of DNA Biosynthetic Process	Gastrulation With Mouth Forming Second Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Spermatogenesis Determination Of Left/right Symmetry Mesoderm Development Anterior/posterior Pattern Specification Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Signal Transduction By Phosphorylation Positive Regulation Of Bone Mineralization BMP Signaling Pathway Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Sperm Ejaculation Penile Erection Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Osteoblast Differentiation Embryonic Skeletal System Development Regulation Of Nitric-oxide Synthase Activity Sertoli Cell Proliferation Cellular Response To BMP Stimulus
Pathways			Signaling by Activin Regulation of signaling by NODAL Signaling by BMP Signaling by NODAL
Drugs
Diseases
GWAS			Response to statin therapy ( 20339536) Urate levels ( 23263486)
Protein-Protein Interactions		3 interactors: ACVR2A ACVR2B BMPR2	17 interactors: ACVRL1 BMP10 BMP6 BMP7 ENG ERBB2IP GDF2 GDF5 GDF9 IGSF1 INHBA INHBB INHBC MAGI2 SYNJ2BP TCTEX1D4 TGFBR3
Entrez ID		2658	92
HPRD ID		05492	00025
Ensembl ID		ENSG00000128802	ENSG00000121989
Uniprot IDs		Q9UK05	B4DWQ2 P27037
PDB IDs		1ZKZ 4FAO	3Q4T 3SOC 4ASX
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Mesoderm Development Positive Regulation Of Activin Receptor Signaling Pathway Lymphatic Endothelial Cell Differentiation Gastrulation Regulation Of Ossification Lymphangiogenesis Lymph Vessel Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Venous Blood Vessel Development Signal Transduction By Phosphorylation Retina Vasculature Development In Camera-type Eye Regulation Of Activin Receptor Signaling Pathway Lymph Vessel Development Pattern Specification Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Blood Vessel Remodeling Skeletal System Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Gastrulation With Mouth Forming Second Embryonic Morphogenesis Artery Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Differentiation Regulation Of BMP Signaling Pathway Endothelium Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Determination Of Left/right Symmetry Tissue Remodeling Determination Of Bilateral Symmetry Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Embryo Development Positive Regulation Of Protein Metabolic Process Retina Development In Camera-type Eye Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Lung Blood Pressure	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway SMAD Protein Signal Transduction BMP Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Protein Modification Process Regulation Of Phosphorus Metabolic Process Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Activin Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Regulation Of Phosphorylation Cell Surface Receptor Signaling Pathway Regulation Of MAPK Cascade Cell Development Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Proliferation Signal Transduction Negative Regulation Of Cell Migration Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cell Motility Cell Differentiation Negative Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Negative Regulation Of Cellular Component Movement Signaling Cell Communication Negative Regulation Of Locomotion Regulation Of Protein Metabolic Process Negative Regulation Of Epithelial Cell Proliferation Tissue Development Regulation Of Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Migration Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Differentiation Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Cell Growth Cellular Response To Growth Factor Stimulus Cellular Response To Organic Substance Response To Organic Substance Cellular Response To Stimulus Response To Growth Factor
Tagcloud ?			5p alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423
Tagcloud (Difference) ?			5p alters applying bmp bmp1a cleaves cluster copyright dies1 furin impairs interferes mapk3 micrornas mineralization mir osteoblast osteoblasts protected reprogramming reserved rights ski smad smad5 smurf1 systematically tgfbr3 zfp423
Tagcloud (Intersection) ?