GDF2 and ACVR2B

Number of citations of the paper that reports this interaction (PMID 22718755)
11

Data Source:
BioGRID (pull down)

		GDF2	ACVR2B
Gene Name		growth differentiation factor 2	activin A receptor, type IIB
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity	Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Growth Factor Binding Inhibin Binding Metal Ion Binding Activin Binding
	Biological Process	Ossification Angiogenesis Patterning Of Blood Vessels Vasculogenesis Osteoblast Differentiation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Cellular Iron Ion Homeostasis Negative Regulation Of DNA Replication Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Interleukin-8 Production Activin Receptor Signaling Pathway Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Development Blood Vessel Morphogenesis Cartilage Development Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Cellular Response To BMP Stimulus Negative Regulation Of DNA Biosynthetic Process	Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Signal Transduction By Phosphorylation Insulin Secretion Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Activation Of Protein Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Palate Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye
Pathways			Signaling by Activin Regulation of signaling by NODAL Signaling by BMP Signaling by NODAL
Drugs
Diseases
GWAS
Protein-Protein Interactions		3 interactors: ACVR2A ACVR2B BMPR2	18 interactors: ACVR1B BMP10 BMP2 BMP7 ERBB2IP GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN SNX1 SNX2 SNX6 SYNJ2BP TGFBRAP1
Entrez ID		2658	93
HPRD ID		05492	04106
Ensembl ID		ENSG00000128802	ENSG00000114739
Uniprot IDs		Q9UK05	Q13705
PDB IDs		1ZKZ 4FAO	2H62 2QLU 4FAO
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Mesoderm Development Positive Regulation Of Activin Receptor Signaling Pathway Lymphatic Endothelial Cell Differentiation Gastrulation Regulation Of Ossification Lymphangiogenesis Lymph Vessel Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Venous Blood Vessel Development Signal Transduction By Phosphorylation Retina Vasculature Development In Camera-type Eye Regulation Of Activin Receptor Signaling Pathway Lymph Vessel Development Pattern Specification Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Blood Vessel Remodeling Skeletal System Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Gastrulation With Mouth Forming Second Embryonic Morphogenesis Artery Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Differentiation Regulation Of BMP Signaling Pathway Endothelium Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Determination Of Left/right Symmetry Tissue Remodeling Determination Of Bilateral Symmetry Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Embryo Development Positive Regulation Of Protein Metabolic Process Retina Development In Camera-type Eye Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Lung Blood Pressure	Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Growth Positive Regulation Of Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Activin Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process BMP Signaling Pathway Regulation Of Signal Transduction Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Positive Regulation Of Metabolic Process Regulation Of Intracellular Signal Transduction Pathway-restricted SMAD Protein Phosphorylation Cell Development Negative Regulation Of Cell Proliferation Regulation Of Cell Differentiation Regulation Of Metabolic Process Signal Transduction Negative Regulation Of Growth Tissue Development Positive Regulation Of Cell Differentiation Signaling Cell Communication Negative Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Anatomical Structure Development Regulation Of Growth Negative Regulation Of Cell Growth Lamellipodium Morphogenesis Positive Regulation Of Ovulation Regulation Of Follicle-stimulating Hormone Secretion Regulation Of Cell Proliferation Cartilage Development Developmental Process
Tagcloud ?			arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a
Tagcloud (Difference) ?			arrays bid bmp2 bmpr1a clustering footprints genechip hybridized infarct ingenuity ipa ligation lmna mi myocardial myocardium nfkbia ninety pathophysiological porcine probe qrt remodelling remote sacrificed sets smad1 tgfb3 tnfrsf1a
Tagcloud (Intersection) ?