GDF2

Description		growth differentiation factor 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Ossification Angiogenesis Branching Involved In Blood Vessel Morphogenesis Vasculogenesis Osteoblast Differentiation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Transcription By RNA Polymerase II Intracellular Iron Ion Homeostasis Negative Regulation Of DNA Replication Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Epithelial Cell Differentiation Positive Regulation Of Interleukin-8 Production Activin Receptor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Blood Vessel Morphogenesis Cartilage Development Positive Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Cellular Response To BMP Stimulus Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Bicellular Tight Junction Assembly
Pathways		Signaling by BMP
Drugs
Diseases
GWAS		Hematocrit ( 32888494) Hemoglobin ( 32888494) Red blood cell count ( 32888494) Refractive error ( 32231278) Systolic blood pressure ( 30224653)
Interacting Genes		6 interacting genes: ACVR1 ACVR2A ACVR2B ACVRL1 BMPR2 ENG
Entrez ID		2658
HPRD ID		05492
Ensembl ID		ENSG00000263761
Uniprot IDs		B2RC63 Q9UK05
PDB IDs		1ZKZ 4FAO 4MPL 4YCG 4YCI 5HZW 5I05 9DPM 9DPN 9DPO 9DPP 9DPQ 9DPR 9DPS 9DPT 9DPU 9DPV 9DPW 9DPX
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Serine/threonine Kinase Activity Activin Binding BMP Signaling Pathway Positive Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Signaling Pathway BMP Receptor Activity Positive Regulation Of SMAD Protein Signal Transduction Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of SMAD Protein Signal Transduction Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Activin Receptor Activity, Type II Endothelial Cell Differentiation Cellular Response To BMP Stimulus Venous Blood Vessel Development Positive Regulation Of Bone Mineralization Growth Factor Binding Activin Receptor Complex Activin Receptor Activity, Type I Lymphatic Endothelial Cell Differentiation Positive Regulation Of Biomineral Tissue Development Positive Regulation Of Ossification Enzyme-linked Receptor Protein Signaling Pathway Positive Regulation Of Osteoblast Differentiation Regionalization Regulation Of Bone Mineralization Cellular Response To Growth Factor Stimulus Lymphangiogenesis Retina Vasculature Development In Camera-type Eye Response To Growth Factor Gastrulation With Mouth Forming Second Positive Regulation Of Cell Differentiation Transforming Growth Factor Beta Binding Regulation Of Ossification Pattern Specification Process Protein Serine/threonine Kinase Activity Regulation Of Activin Receptor Signaling Pathway Outflow Tract Septum Morphogenesis Regulation Of Osteoblast Differentiation Protein Kinase Activity Positive Regulation Of Developmental Process Receptor Complex Blood Vessel Remodeling Animal Organ Development Regulation Of Multicellular Organismal Development Kinase Activity Anatomical Structure Morphogenesis Artery Development Gastrulation Regulation Of Cell Differentiation
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