GDF2

Gene Name		growth differentiation factor 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Ossification Angiogenesis Patterning Of Blood Vessels Vasculogenesis Osteoblast Differentiation Negative Regulation Of Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Cellular Iron Ion Homeostasis Negative Regulation Of DNA Replication Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Angiogenesis Negative Regulation Of Cell Growth BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Interleukin-8 Production Activin Receptor Signaling Pathway Growth Regulation Of Apoptotic Process Regulation Of MAPK Cascade Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Development Blood Vessel Morphogenesis Cartilage Development Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Cellular Response To BMP Stimulus Negative Regulation Of DNA Biosynthetic Process
Pathways
Drugs
Diseases
GWAS
Protein-protein Interactions		3 interactors: ACVR2A ACVR2B BMPR2
Entrez ID		2658
HPRD ID		05492
Ensembl ID		ENSG00000128802
Uniprot IDs		Q9UK05
PDB IDs		1ZKZ 4FAO
Enriched GO Terms of Interacting Partners?		Activin Receptor Signaling Pathway Positive Regulation Of Bone Mineralization Positive Regulation Of Biomineral Tissue Development Regulation Of Bone Mineralization Positive Regulation Of Osteoblast Differentiation BMP Signaling Pathway Positive Regulation Of Ossification Regulation Of Osteoblast Differentiation Mesoderm Development Positive Regulation Of Activin Receptor Signaling Pathway Lymphatic Endothelial Cell Differentiation Gastrulation Regulation Of Ossification Lymphangiogenesis Lymph Vessel Morphogenesis Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Venous Blood Vessel Development Signal Transduction By Phosphorylation Retina Vasculature Development In Camera-type Eye Regulation Of Activin Receptor Signaling Pathway Lymph Vessel Development Pattern Specification Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Blood Vessel Remodeling Skeletal System Development Regulation Of Pathway-restricted SMAD Protein Phosphorylation Gastrulation With Mouth Forming Second Embryonic Morphogenesis Artery Development Positive Regulation Of Protein Phosphorylation Endothelial Cell Differentiation Regulation Of BMP Signaling Pathway Endothelium Development Positive Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Determination Of Left/right Symmetry Tissue Remodeling Determination Of Bilateral Symmetry Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Embryo Development Positive Regulation Of Protein Metabolic Process Retina Development In Camera-type Eye Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Protein Phosphorylation Regulation Of Lung Blood Pressure
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