PYGO2 and DCAF1

Number of citations of the paper that reports this interaction (PubMedID 26170450)
97

Data Source:
BioGRID (pull down)

		PYGO2	DCAF1
Description		pygopus family PHD finger 2	DDB1 and CUL4 associated factor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Beta-catenin-TCF Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Centrosome Cytoskeleton COP9 Signalosome Cul4-RING E3 Ubiquitin Ligase Complex
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Histone Acetyltransferase Regulator Activity Histone Binding Metal Ion Binding	Nucleotide Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Nuclear Estrogen Receptor Binding Protein Serine Kinase Activity Histone H2AT120 Kinase Activity Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Kidney Development Lens Development In Camera-type Eye Spermatid Development Spermatid Nucleus Differentiation Brain Development Wnt Signaling Pathway Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Developmental Growth Roof Of Mouth Development Canonical Wnt Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Protein Ubiquitination B Cell Differentiation V(D)J Recombination Cell Competition In A Multicellular Organism Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Base-excision Repair, AP Site Formation Via Deaminated Base Removal
Pathways		Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Inflammatory bowel disease ( 27569725) Prostate cancer ( 23535732)	Asthma ( 32296059)
Interacting Genes		7 interacting genes: AKT1 BCL9 DCAF1 KAT2A NF2 SUPT3H TRRAP	25 interacting genes: ATM ATR CCP110 CD274 EXO1 FOXM1 H3-3A H3-4 H3C1 HLTF IRF1 KATNA1 LATS1 LATS2 NF2 PLK4 PRKDC PWP1 PYGO2 RAG1 TET2 TP53 UBE2D2 UBE2D3 USP2
Entrez ID		90780	9730
HPRD ID		06065	11674
Ensembl ID		ENSG00000163348	ENSG00000145041
Uniprot IDs		Q5T170 Q9BRQ0	Q9Y4B6
PDB IDs		2XB1 4UP0 4UP5 8HIB	3WA0 4CC9 4P7I 4PXW 4Z8L 5AJA 5JK7 6N45 6ZUE 6ZX9 7OKQ 7SSE 7UFV 7V7B 7V7C 8F8E 8OG5 8OG6 8OG7 8OG8 8OG9 8OGA 8OGB 8OGC 8OO5 8OOD 9B9H 9B9T 9B9W 9BA2 9BHR 9BHS 9C1Q 9D4E 9DLW
Enriched GO Terms of Interacting Partners?		Transcription Factor TFTC Complex SAGA Complex Regulation Of DNA Metabolic Process Regulation Of Cellular Response To Stress Regulation Of RNA Splicing Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Glucose Metabolic Process Positive Regulation Of RNA Biosynthetic Process Response To Nerve Growth Factor Regulation Of Organelle Assembly Positive Regulation Of DNA-templated Transcription Cellular Response To Nerve Growth Factor Stimulus Transcription Coactivator Activity Regulation Of DNA Repair Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Gluconeogenesis Hexose Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Striated Muscle Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of TRNA Methylation Regulation Of Cell Cycle Peptidyl-lysine Glutarylation Histone Glutaryltransferase Activity Histone Succinyltransferase Activity Peptide Glutaryltransferase Activity Histone H2AT120 Kinase Activity Cell Competition In A Multicellular Organism Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Glucose Metabolic Process Cellular Response To Tumor Necrosis Factor Nucleoplasm Muscle Cell Differentiation Negative Regulation Of Protein Localization To Lysosome Histone H3K9 Acetyltransferase Activity Carbohydrate Biosynthetic Process Negative Regulation Of Small Molecule Metabolic Process Positive Regulation Of Protein Localization To Endoplasmic Reticulum Response To Insulin-like Growth Factor Stimulus Mammalian Oogenesis Stage TRNA (guanine-N7)-methylation Response To Tumor Necrosis Factor Cellular Response To Rapamycin Glucose Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Neuron Intrinsic Apoptotic Signaling Pathway Nucleus	Histone H2AXS139 Kinase Activity Nucleus Chromatin Organization Regulation Of Cell Cycle Positive Regulation Of Cellular Component Biogenesis DNA Binding DNA Repair Somatic Cell DNA Recombination Chromosome Organization Nucleoplasm DNA Metabolic Process DNA Strand Resection Involved In Replication Fork Processing Replicative Senescence Telomere Organization Response To Gamma Radiation Establishment Of RNA Localization To Telomere Establishment Of Protein-containing Complex Localization To Telomere Positive Regulation Of Telomerase Catalytic Core Complex Assembly Signal Transduction In Response To DNA Damage V(D)J Recombination Chromatin Remodeling Centrosome DNA-dependent Protein Kinase Activity Chromosome, Telomeric Region Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Cellular Response To Gamma Radiation Protein Serine Kinase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Protein-containing Complex Assembly Pre-B Cell Allelic Exclusion DNA Damage Response DNA Damage Checkpoint Signaling Macromolecule Metabolic Process ATP Binding Nucleotide Binding Protein Serine/threonine Kinase Activity Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Metabolic Process Regulation Of T Cell Apoptotic Process Regulation Of Signal Transduction By P53 Class Mediator Replication Fork Processing B Cell Lineage Commitment Regulation Of Protein-containing Complex Assembly Regulation Of Organelle Assembly Regulation Of Telomere Maintenance Via Telomerase T Cell Differentiation In Thymus Response To Radiation Regulation Of Hippo Signaling Somitogenesis
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