PYGO2 and SUPT3H

Number of citations of the paper that reports this interaction (PMID 20937768)
10

Data Source:
BioGRID (pull down)

		PYGO2	SUPT3H
Gene Name		pygopus family PHD finger 2	suppressor of Ty 3 homolog (S. cerevisiae)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm	SAGA Complex Nucleus Nucleoplasm Transcription Factor TFIID Complex STAGA Complex Transcription Factor TFTC Complex
	Molecular Function	Chromatin Binding Protein Binding Zinc Ion Binding Histone Acetyltransferase Regulator Activity Histone Binding	DNA Binding Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Heterodimerization Activity
	Biological Process	In Utero Embryonic Development Kidney Development Lens Development In Camera-type Eye Spermatid Nucleus Differentiation Brain Development Post-embryonic Development Mammary Gland Development Regulation Of Mammary Gland Epithelial Cell Proliferation Regulation Of Histone Acetylation Positive Regulation Of Chromatin Binding Developmental Growth Regulation Of Histone H3-K4 Methylation Palate Development Canonical Wnt Signaling Pathway	Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Histone Deubiquitination Histone H3 Acetylation Positive Regulation Of Transcription, DNA-templated
Pathways		misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer deactivation of the beta-catenin transactivating complex	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Attention deficit hyperactivity disorder ( 18839057) Bone mineral density ( 22504420) Height ( 19893584 23563607 18391951) Obesity-related traits ( 23251661) Osteoarthritis ( 22763110) Stroke (ischemic) ( 22941190)
Protein-Protein Interactions		5 interactors: BCL9 KAT2A NF2 SUPT3H TRRAP	5 interactors: DDB1 HIST3H3 MYC PYGO2 TCF3
Entrez ID		90780	8464
HPRD ID		06065	04254
Ensembl ID		ENSG00000163348	ENSG00000196284
Uniprot IDs		Q5T170 Q9BRQ0	B4E1H0 O75486
PDB IDs		2XB1
Enriched GO Terms of Interacting Partners?		Histone Deubiquitination Protein Deubiquitination Histone Acetylation Internal Peptidyl-lysine Acetylation Protein Modification By Small Protein Removal Peptidyl-lysine Acetylation Internal Protein Amino Acid Acetylation Protein Acetylation Peptidyl-lysine Modification Histone H3 Acetylation Histone Modification Histone H4 Acetylation Chromatin Modification Chromatin Organization Regulation Of Protein Stability Regulation Of Gene Expression Myotube Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Nitrogen Compound Metabolic Process Peptidyl-amino Acid Modification Chromosome Organization Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Histone H3-K14 Acetylation Positive Regulation Of Gluconeogenesis By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Schwann Cell Proliferation Telencephalon Development Organelle Organization Regulation Of Gluconeogenesis By Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Regulation Of Hippo Signaling Histone H4-K12 Acetylation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Histone H2A Acetylation Glial Cell Proliferation Regulation Of Metabolic Process Forebrain Development Tissue Development Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Gluconeogenesis Growth Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of JAK-STAT Cascade Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Ectoderm Development	Wnt Signaling Pathway Canonical Wnt Signaling Pathway Chromosome Organization Organelle Organization Cellular Response To UV Cellular Response To Light Stimulus Chromatin Modification Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Chromatin Organization Response To UV Cellular Response To Radiation Fibroblast Apoptotic Process Regulation Of Cell Cycle Positive Regulation By Virus Of Viral Protein Levels In Host Cell Positive Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Regulation Of Chromosome Organization DNA Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Positive Regulation Of Chromatin Binding Axial Mesoderm Morphogenesis Negative Regulation Of Monocyte Differentiation Immunoglobulin V(D)J Recombination UV-damage Excision Repair Positive Regulation Of Cell Proliferation Involved In Kidney Development Cell Surface Receptor Signaling Pathway Regulation Of Epithelial Cell Proliferation Positive Regulation Of Viral Release From Host Cell Kidney Development Homeostatic Process Renal System Development Axial Mesoderm Development Response To Light Stimulus B Cell Lineage Commitment Regulation Of Cell Proliferation Histone H2A Monoubiquitination Urogenital System Development Histone Modification Regulation Of Mitotic Cell Cycle Regulation Of Monocyte Differentiation Peyer's Patch Development Histone H2A Ubiquitination Response To Radiation Regulation Of Mammary Gland Epithelial Cell Proliferation Natural Killer Cell Differentiation Nucleotide-excision Repair, DNA Damage Removal Regulation Of Telomere Maintenance Anterior/posterior Axis Specification, Embryo Regulation Of Cell Cycle Process Positive Regulation Of DNA Biosynthetic Process
Tagcloud ?		catenin compartment converge depilation dispensable emerged epithelia excessive facilitates follicle hair holds homeobox homolog hyperactivation hyperplasia keratinocytes lhx2 lim maximizes prime progenitor prominent promise pygopus regeneration stem trichofolliculoma wnt
Tagcloud (Difference) ?		catenin compartment converge depilation dispensable emerged epithelia excessive facilitates follicle hair holds homeobox homolog hyperactivation hyperplasia keratinocytes lhx2 lim maximizes prime progenitor prominent promise pygopus regeneration stem trichofolliculoma wnt
Tagcloud (Intersection) ?